Mono/Lyme (lec 24)

Question 1

Infectious Mononucleosis caused by?

Answer 1

Epstein-Barr virus

Question 2

Infectious Mononucleosis presentation?

Answer 2

Incubation 1-2 mo
Prodrome 3-5 days: viral sxs
ST w/ exanthem and petechia,
symm LAD, fever
(P) hepatomegaly

PCN rash

Question 3

Downey Cells are?

Answer 3

Atypical lymphocytes (T cells) found in Infectious Mononucleosis

Question 4

Epstein-Barr virus epidemiology?

Answer 4

P-to-P (virus in saliva for month)
(U) 17-25 yo
Kids U asympt

Question 5

Epstein-Barr virus link to malignancy?

Answer 5

Causes Burkitt’s lymphoma

Africa

Question 6

Epstein-Barr virus diagnostics?

Answer 6

HETEROPHILE Antibodies (adults)
IgM anti-capsid antigen (kids)

Question 7

Lyme Dz caused by?

Answer 7

B. burgdorferi (spirochete)
Tick vector
Small mammal reservoir

Question 8

Lyme Dz presentation: Stage 1?

Answer 8

Acute localized:
ERYTHEMA MIGRANS @ tick bite,
Bulls eye, expands/fades < 1 mo

Question 9

Lyme Dz presentation: Stage 2?

Answer 9

Subacute dissemination (wks - months post):
Flu sxs,
ASYMMETRICAL ARTHRITIS (large joints swell),
Multiple annular lesions,
Lasts days - wks

(P) hepatitis/meningitis

Question 10

Lyme Dz presentation: Stage 3?

Answer 10

Chronic (yr-yrs post):

↑ ARTHRITIS

Question 11

Lyme Dz diagnostics?

Answer 11

Positive by 4th wk:
EIA + Western blot
False + w/ syphilis, mono, SLE, RA

Question 12

Lyme Dz tx?

Answer 12

if sxs amox or doxy 10-21 days