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IMM005 > Molecules of the immune system > Flashcards

Molecules of the immune system Flashcards

1
Q

Cells expressing CD3

A

All T cells

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2
Q

Cells expressing CD2

A

T cells

NK cells

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3
Q

Cells expressing CD4

A

T helper cells

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4
Q

Cells expressing CD8

A

Cytotoxic T cells

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5
Q

Role of CD14

A

Act as receptor for LPS

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6
Q

Cells expressing CD15

A

NK cells

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7
Q

Cells expressing CD19 and CD20

A

B cells

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8
Q

Cells expressing CD25

A

Tregs

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9
Q

Role of CD25

A

Receptor for IL-2

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10
Q

Cells expressing CD56

A

NK cells

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11
Q

Cells expressing CD58

A

APCs

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12
Q

Role of CD58

A

Binds to CD2

Stimulates T cells

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13
Q

Cells expressing CD40

A

APCs

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14
Q

Cells expressing CD40L

A

Th cells

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15
Q

Role of CD40L

A

Reacts with APCs

Stimulates APCs to produce more costimulatory molecules and IL-12

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16
Q

Cells expressing CD28

A

T cells

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17
Q

Cells expressing CD80/86

A

APCs

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18
Q

Cells expressing CTLA4

A

T cells

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19
Q

Cells expressing PD1

A

T cells

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20
Q

CD molecules expressed by all T cells

A

CD3

CD28

CTLA4

PD1

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21
Q

CD molecules expressed by NK cells

A

CD2

CD15

CD56

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22
Q

CD molecules expressed by APCs

A

CD56

CD40

CD80/86

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23
Q

Role of interferons in the immune system

A

Inhibit viral invasion through upregulating expression of molecules that inhibit viral proliferation

Downregulates Th2 activity

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24
Q

Which cells express IFN?

A

Th1

NK

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25
Q

Cells expressing IL-1

A

Monocytes

Macrophages

DCs

26
Q

Role of IL-1

A

Inflammatory

Induces changes in the vascular endothelium to facilitate leukocyte entry

27
Q

Role of IL-6

A

Inflammatory

Induces changes to vascular endothelium to facilitate leukocyte entry

28
Q

Role of IL-8

A

Inflammatory

29
Q

Inflammatory interleukins

A

IL-1

IL-6

IL-8

30
Q

Cell secreting IL-2

A

T cells

31
Q

Role of IL-2

A

Stimulates T and B cell proliferation

Production of memory and effector T cells

32
Q

Cell secreting IL-3

A

Th2

33
Q

Role of IL-3

A

Stimulates the differentiation of stem cells down the myeloid path

34
Q

Role of IL-4

A

Stimulates Th2 differentiation

Class-switches B cells to IgE

35
Q

Cells secreting IL-4

A

Th2

36
Q

Cells secreting IL-5

A

Th2

37
Q

Role of IL-5

A

Recruits and activates eosinophils

38
Q

Role of IL-7

A

Promotes the differentiation into the lymphoid path

Stimulates the proliferation of all lymphoid lineage cells

39
Q

Role of IL-9

A

Drives mast cell recruitment

40
Q

Cells secreting IL-9

A

Th2

41
Q

Cells secreting IL-10

A

Monocytes

Th2

Treg

42
Q

Role of IL-10

A

Anti-inflammatory

Stimulates B cell proliferation

43
Q

Cells secreting IL-12

A

DCs

Macrophaes

Neutrophils

44
Q

Role of IL-12

A

Stimulates differentiation of Th1

ENhances cytotoxic activity of CD8 and NK cells

45
Q

Cells secreting IL-13

A

Th2

46
Q

Role of IL-13

A

Induces epithelial cell proliferation and stimulates mucus production

Hinders parasite colonisation of the epithelium

47
Q

Cells secreting IL-17

A

Th17

48
Q

Role of IL-17

A

Pro-inflammatory

49
Q

Role of IL-21

A

Proliferation

Differentiation of antibody producing plasma B cells

50
Q

Cells secreting TNFa

A

Cytotoxic lymphocytes

51
Q

Role of TNFa

A

Inflammatory cytokine

Induces changes in the vascular endothelium to facilitate leukocyte entry into the inflammatory site

52
Q

Role of TGFb

A

Immunosuppressant

53
Q

Cells secreting TGFb

A

Tregs

54
Q

Complement carrying out mast cell degranulation

A

C3a

C4a

55
Q

Complement carrying out opsonisation

A

C3b
C4b
C5b

56
Q

Complement carrying out chemotaxis

A

C5a

57
Q

Complement forming the MAC

A

C5b

C6-C9

58
Q

Role of IgA

A

Primary defense against local infections

Abundance in saliva, tears, bronchial secretions and prosatic fluids

59
Q

Role of IgG

A

Produced in later stages of infection

Persists for life after infection

60
Q

Role of IgD

A

Along with IgM, the only antibody found bound to the cell membrane

Found on naive B cells

61
Q

Role of IgM

A

Produced in primary response to infection

Multiple arms increase avidity

62
Q

Role of IgE

A

Key mediator in allergies

IMM005 (17 decks)

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