Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IMM005 > Cells of the lymphoid system > Flashcards

Cells of the lymphoid system Flashcards

1
Q

Which proteins do all T cells express?

A

CD2

CD3

CD28

CTLA4

PD1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the 4 main classes of Th cells?

A

Th1

Th2

Tfh

Th17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What two cytokines to Th1 cells produce?

A

IFNg

IL-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the role of Th1 cells?

A

Destroy intracellular pathogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Role of IFNg

A

Activates macrophages and help them become more adept at destroying intracellular pathogens

Released upon recognising non-native antigens presented on APCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Role of IL-2

A

Interaction of Th1 and APCs through CD40 and CD40L stimulates APCs to produce IL-12

IL-12 and IL-2 help proliferation of CD8+ T cells and NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which cytokines do Th2 cells release?

A 
IL-3
IL-4
IL-5
IL-9
IL-13
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do Th2 cells protect against?

A

Allergies

Parasitic infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Role of cytokines secreted by Th2 cellls

A

Activation of granulocytes and mast cells

Promote class switching to IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cytokine expressed by Tfh cells

A

IL-21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Role of Tfh cells

A

Express CD40L to interact with CD40 on B cells

Do not present antigen

Rather promote proliferation, class switching and affinity maturation in B cell follicles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cytokines expressed by Th17 cells

A

IL-17

IL-22

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What do Th17 cells protect against?

A

Extracellular pathogens and fungi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Role of Th17 cells

A

Promotes neutrophil recruitment and tissue inflammation

Often present in mucosal surfaces

IL-17 stimulates other non-immune cells to produce chemokines leading to neutrophil recruitment and inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Markers of Tregs

A

CD25

FoxP3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Two main cytokines released by Tregs

A

IL-10

TGFb

17
Q

What is the role of IL-10 secreted by Tregs?

A

Stimulates B cell proliferation

Anti-inflammatory by suppressing Th1 cells

18
Q

What important receptor do Tregs express?

A

CTLA-4

Modifies APCs through blockign or removing B7

19
Q

What is the marker of Cytotoxic T cells?

A

CD8

20
Q

4 ways in which CTLs carry out their function

A

Interact with MHC class I

Kill infected cells

Produce IFN

Activates surrounding macrophages through releasing cytokines

21
Q

What two ways do CTLs kill infected cells?

A

Death-receptor-dependent killing - interact with Fas on target to induce apoptosis

Granule-dependent killing - perforin produces pores on the membrane which allows the insertion of granzymes

22
Q

Role of IFN

A

Attempt to inhibit viral invasion of host cells through

  • inducing an antiviral state
  • inducing intracellular killing
23
Q

Which proteins do B cells express?

A

CD19

CD80/86

24
Q

Which proteins do NK cells express?

A

CD16

CD56

25
Q

What is the difference between the ways NK cells eliminate pathogens, and the way CTLs eliminate
pathogens?

A

Instead of looking for the foreign antigens, they look at the MHC itself

Cells missing MHC evade immune responses

IMM005 (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions