Molecules need to know Flashcards
CD molecules Expression (func3on)
CD19
CD80/86 CD40
CD3 CD4 CD8 CD28 CD40L CD25
Cytokines Source, Effect
IL-2 IL-4, (IL-9) IL-6, IL-8 IL-10 IL-12, IL-17, (IL-22, IL-23) (IL-7) (IL-21) IFN-gamma – Type II interferon IFN-alpha/beta – Type I interferon TNF-alpha (TGF-beta)
Miscellaneous
MHC class I and MHC class II T cell receptor (TCR) FoxP3 CCR7 (CXCR5) Toll-like receptors B cell receptor (BCR)
What is the function of IL-17 secreted by Th 17 cells?
Recruits & activates innate immune response cells, such as neutrophils.
What is the function of IL-22 secreted by Th17
Induce secretion of anti-microbial peptides in skin & gut.
What is the function of IL-21 secreted by Follicular Helper T cells
Initiates antibody production in B cells
What is the function of IL-9 secreted by Th2 cells
activates mast cells
Cytokines: Interferons
Action: Anti-viral proteins
Cytokines: chemokine family
Action: direct cell migration, adhesion and activation
Cytokines: Tumour necrosis factor
Action: regulate inflammatory and immune responses
Cytokines: Interleukins
Action: variety of actions dependent on the interleukin and cell type
Cytokines: Haematopoietins
Action: promote cell proliferation and differentiation
Cytokines: Transforming growth factor beta family
Action: regulation of immune cells
pleiotropic
different effects on different types of target cells
redundant
multiple cytokines have same effect