molecular mechanisms of synapse refinement Flashcards
what is the substrate for experience dependent learning
synaptic refinement
when is the only time when monocular deprivation will shift
during the critical period
what does enhancing GABA function do to the critical period
shifts the period earlier
what does delaying GABA function do to the CP?
shifts critical period later
why does GABA change the critical period
because it changes the excitatory-inhibitory balance
what develops first excitatory or inhibitory
excitatory
what can shift the CP earlier?
enhancing GABAergic function, benzodiazepines, BDNF overexpression
what can shift the CP later?
reducing GABAergic function, dark-rearing, deleting GAD65
what cell type is important for the CP
parvalbumin + basket cells. they are extrinsic to the cortex and arrive at the start time for the CP.
what factor is important for the maturation of PV+ basket cells
BDNF
what precedes and parallels changes in the LGN inputs?
changes in pyramidal cells.
what changes in pyramidal cells are noted during maturation?
pyramidal spine motility and remodeling. these are important for cortical plasticity
what is tPA
tissue plasminogen activator. serine protease. expressed during times of synaptic reorganization in order to manipulate the ECM.
what are the stages of spine retraction and reorganization
1) detection -spine motility (tPA)
2) expression -spine elimination axon retraction
3) consolidation -spine recovery, axon outgrowth
what are perineuronal nets?
they are structural component, mainly ECM. that surrounds neurons and limits the synaptic space on cell surface.
