axon guidance Flashcards
where does axon guidance take place?
at the growth cone
what attracts commissural axons and why
the floor plate, because of netrin and Shh secretion
what do netrins have homology too
laminins (B2 chain)
what expresses netrin, why is this important
floor plate. it attracts axons from the dorsal surface
what does the roof plate do to commissural axons
repels them
what is in the roof plate that causes it to repel axons
BMP7 and GDF7
what does BMP7 do to growth cones
it causes them to collapse
what is the open book culture
cutting the nerve cord at the roof plate and observing the movement of commissural axons
what signal stimulates the movement of commissural axons that have crossed the midline
wnt proteins
what is the receptor for wnt
frizzled
what receptor and signal inhibits recrossing
slit and roundabout (Robo)
where are slits expressed
in the floor plate
what does slit signaling do
repels the axons
where is robo3.1 expressed
in the precrossiing neurons
where is robo3.2 expressed
in the postcrossing neurons
