Molecular Genetics & DNA Repair Flashcards

1
Q

DNA to RNA is also known as…

A

Transcription

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2
Q

RNA to Proteins is also known as…

A

Translation

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3
Q

What are the purines?

A

A & G

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4
Q

What are the pyrimidines?

A

C & T

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5
Q

DNA vs RNA

Which has ribose?

A

RNA

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6
Q

DNA vs RNA

Which has a “H” in Carbon 2?

A

DNA

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7
Q

Which one uncoils the DNA?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Exonuclease
DNA Ligase
A

Topoisomerase

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8
Q

Which one disassociates the parental strands into ssDNA?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Exonuclease
DNA Ligase
A

Helicase

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9
Q

Which one binds ssDNA?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Exonuclease
DNA Ligase
A

single stranded binding protein

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10
Q

Which one lays down a short RNA primer?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Exonuclease
DNA Ligase
A

Primase

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11
Q

Which one synthesizes new strand of DNA?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Exonuclease
DNA Ligase
A

DNA Polymerase

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12
Q

Which one removes RNA primer?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Endonuclease
DNA Ligase
A

Endonuclease

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13
Q

Which one seals the breaks between fragments?

Topoisomerase
Helicase
Single Stranded Binding Proteins
Primase
DNA Polymerase
Exonuclease
DNA Ligase
A

DNA Ligase

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14
Q

What is the ultimate source of all genetic variation?

A

DNA mutation

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15
Q

Most common DNA mutation in human genome

Depurination/Deamination
Thymine Dimer Formation
Alkylating Attack on Purine ring
Addition of Bulky Adducts
DNA strand breakage
A

Depurination/Deamination

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16
Q

Mutated by sunlight, alkylating agents, or radiation

Depurination/Deamination
Thymine Dimer Formation
Alkylating Attack on Purine ring
Addition of Bulky Adducts

A

Thymine Dimer Formation

17
Q

Many carcinogens mutate DNA by the addition of *****

Depurination/Deamination
Thymine Dimer Formation
Alkylating Attack on Purine ring
Addition of Bulky Adducts

A

Addition of Bulky Adducts

18
Q

Where are the DNA damage checkpoints?

A

G1/S

G2/M

19
Q

When DNA damage is detected, a signaling cascade is initiated where?

A
  1. BRCA1 (repair)

2. p53 (apoptosis)

20
Q

How do you repair thymine dimers?

A

Direct reversion