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Genomics > Molecular Biology of Cancer > Flashcards

Molecular Biology of Cancer Flashcards

1
Q

What is cancer?

A

NOT a single disease, but rather a group of diseases characterized by uncontrolled growth

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2
Q

What is the root of cancer cell development?

A

Genetic mutation

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3
Q 
Carcinomas
Sarcomas
Leukemias
Lymphoma/Myeloma
CNS cancer

Which begin in connective tissue such as bone?

A

Sarcomas

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4
Q 
Carcinomas
Sarcomas
Leukemias
Lymphoma/Myeloma
CNS cancer

Which begin in the bone marrow?

A

Leukemias

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5
Q 
Carcinomas
Sarcomas
Leukemias
Lymphoma/Myeloma
CNS cancer

Which begin in the brain/spinal cord + most common originating in glial cells?

A

CNS cancers

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6
Q 
Carcinomas
Sarcomas
Leukemias
Lymphoma/Myeloma
CNS cancer

Which begin in the lymph glands?

A

Lymphomas/Myelomas

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7
Q 
Carcinomas
Sarcomas
Leukemias
Lymphoma/Myeloma
CNS cancer

Which begin in the epithelial tissue such as skin?

A

Carcinomas

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8
Q 
Carcinomas
Sarcomas
Leukemias
Lymphoma/Myeloma
CNS cancer

Which is the most common type of cancer?

A

Carcinomas

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9
Q

Normal vs Cancer Cells

Do not mature into functional cells

A

Cancer

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10
Q

Normal vs Cancer Cells

Controlled cell division

A

Normal

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11
Q

Normal vs Cancer Cells

Mortal (die after 50 divisions)

A

Normal

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12
Q

Normal vs Cancer Cells

Control of angiogenesis

A

Normal

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13
Q

Normal vs Cancer Cells

Unresponsive to apoptosis

A

Cancer

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14
Q

Normal vs Cancer Cells

Contact inhibition

A

Normal

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15
Q

Normal vs Cancer Cells

Increased rate of division

A

Cancer

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16
Q

Normal vs Cancer Cells

Can easily detach from each other?

17
Q

Normal vs Cancer Cells

Stay bound together

18
Q

Normal vs Cancer Cells

Controlled cell division

19
Q

Which of the following is FALSE?

Cancer cells display a loss of contact inhibition

Cancer cells are characterized by controlled cell division

Cancer cells are resistant to apoptosis

Cancer is a group of diseases

A

Cancer cells are characterized by controlled cell division

20
Q

Why is cancer so difficult to treat?

A

Cancer cells continue mutating and become resistant to therapies

Many chemos are cytotoxics and reach dose-limiting toxicities before cancer can be eradicated

Targets for inhibition which have counterparts w/ important functions in normal cells

Cancer trends can change over time

21
Q

In the cell cycle, where is cancer formed?

A

From G0 to G1 transition; cancer cannot enter G0

22
Q

T/F

Cancer is caused by novel genes

A

False; caused by mutations of existing genes

23
Q

What are the main types of protein kinases?

A
  1. Tyrosine
  2. Serine
  3. Threonine

Genomics (11 decks)

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