Molecular Effects Of Radiation Flashcards
Free radicles carry what?
An unpaired electron
What is the simplest free radical
Hydrogen
Free radicles try to
Gain an electron
Get attached to an electron rich center
Combine with another free radical
Reactivity of free radicals
Free radicles are highly reactive
Hydrogen free radicle react with which molecules
Organic molecules
How does hydrogen free radicle reacts with organic molecules
1- By abstracting another H atom to form a hydrogen molecule and an organic free radical
2- By attaching to an electron rich center of a substrate molecule
How is the lifetimes of simple free radicles ( H or OH)
Very short
What is the effect of having very short lifetime to free radicles
Even though they are highly reactive they do not exist long enough to migrate from the site of formation to the cell nucleus
Molecular oxygen reacts with most free radicles to form
Peroxy free radicles—> goes to nucleus and causes damage in the cell
Which molecule is the enhancer of irreversible radiation damage
Oxygen
Which inorganic substance is able to reduce the effects of water radicals
Cl
Which molecule reduce the effect of radiation
Histidine
Which molecules reduces the radiation and which molecules increases the radiation
Histidine and Cl reduces
O2 increases
The biological effects of radiation are generally dependent on
Dose rate
Radiolysis of water
The decomposition of water molecules due to ionizing radiation
X-ray photon interact with water and ionize it
