Molecular Basis Of Inheritance Flashcards
Nucleosomes are the repeating units of?
chromatin
A typical nucleosome contains ___ bp of dna
200
Dna as an acidic substance was identified by
Friedrich meischer in 1869. NUCLEIN
How many nucleosome arw present in a mammalian cell?
3.3 * 10^7
The packaging of chromatin at higher level requires additional set of proteins that collectively are called
NHC
NON HISTONE CHROMOSOMAL PROTEIN
Transforming principle
1928 Fredrick Griffith
The unequivocal proof of dna js genetic material was given by
Alfred Hershey and Martha chase in 1952
Worked on bacteriophage
For transmission of genetic material
RNA IS BETTER
Dna replicates semi conservatively was proven first in
E.coli.. experiment - Matthew Meselson and Franklin Stahl
1958
E coli divides in
20 mins
The main enzyme for dna replication is
DNA DEPENDENT DNA POLYMERASE
E Coli completes replication in
18 mins
Who serves dual purpose in replication
Deoxy ribonucleoside triphosphates
Can ds rna be translated
Naurrr
Wat is the polarity of template strand
3’ to 5’
Which sequences do not appear in mature and processed rna
INTRONS
Split gene arrangement is seen in ?
Eukaryotes
M-rna acts as a template
R-rna is structural and catalytic then wat is the function of t-rna
T- RNA brings amino acids and reads the genetic code
STATE TRUE OR FALSE
There is a SINGLE dna dependent rna polymerase that catalyses transcription of all types of rna is bacteria
TRUE
In prokaryotes wat is the predominant site for control of gene expression
Control of the rate of transcriptional initiation
Lac operon was seen by
Geneticist Francois Jacob and biochemist Jacque Monod
Can glucose and galactose act as an inducer for lac operon
Naurr
Largest human gene
Dystrophin gene at 2.4 million bases
State true or false
Almost all (99.9%) nucleotide bases are exactly the same in all
True
Chromosome 1 has most genes ( 2968) then which has the lowest
Y has fewest (231)
Wat is dna polymorphism
If an inheritable mutation is observed in a population at high frequency it is referred to as DNA polymorphism
Vntr belongs to
Mini satellite
Size of vntr varies from
0.1 to 20 kbp
Thr smallest RNA is
T- RNA
If coding strand has sequence CAT the transcribed mrna will have
CAU
Reverse transcription is done by?
RNA dependent DNA POLYMERASE
Which chromosomes in humans has the most genes
Chromosomes 1
In eukaryotes peptidyl transferase which catalyses the synthesis of peptide bond is
28S rRNA
During DNA packaging kn eukaryotes histone octamer doesn’t have
H1
Darwin’s finches are examples of
Adaptive radiation
Divergent evolution
Geographical isolation
Founders effect
A nucleotide lacks
Phosphodiester linkage
How many types of HISTONEs form the core part of nucleosome
4
Eras period epochs
Yess
