molecular aspects of synaptic function Flashcards
chemical transmission what happens as ca2+ enters the cell terminal
synaptotagmin binds Ca2+ which causes a conformational change
what happens after the calcium sensor has sensed ca
allows SNARE proteins to promote fusion
vesicle moves to the plasma membrane and fuses
NT release
causing excitation or inhibition
what is the Active zone
the close proximity of the vesicle and the plasma membrane
what is asymetric and symetric
asymetric = excitatory symetric = inhibitory
key features of glutamate receptors
4 subunits
glutamate binding site is on the outside
cation channel
binds molecule PSD-95 on inside postsynaptic cell
what is PSD
post synaptic density
glycine (gaba) receptors key features
5 subunits
binds glycine on the outside
anion channel
binds gephyrin on inside postsynaptic cell
what tags help recognise PSD-95 and gephyine
presynaptic for both is neurexins
postsynaptic for PSD = neuroligin 1
postsynaptic for gerphyine = neuroligin 2
glut —– gaba
glutamic acid decarboxylase GAD
glut into vesicle
gaba into vesicle
glut = VMAT gaba= VIATT
what SNARE proteins regulate the assembly of other proteins
NSF and SNAP
what SNARE proteins is bound to the vesicle
synaptobrevin
what SNARE proteins are bound to the plasma membrane
synataxin
SNAP-25
