Molar PG Flashcards
OBS
Gestational trophoblastic disease consists of
Spectrum of conditions
* Partial mole
* Complete mole
* Invasive or metastatic moles
* Choriocarcinoma
* Placental site trophoblastic disease
* Epithelioid trophoblastic tumor
GTD
malignant gestational trophoblastic diseases types
- Choriocarcinoma
- Placental site trophoblastic tumor (PSTT)
- Epithelioid trophoblastic tumor
GTD
Complete mole pathophysiology
Fertilization of an empty ovum by a sperm, then duplicates OR empty ovum if fertilized by 2 sperms
GTD
Partial mole pathophysiology
Haploid ovum is fertilized by 2 sperms. 69 XXX, XXY, XYY
GTD
Partial mole rare karyotype
XYY
GTD
Complete mole consists of …. sets of paternal genes, maternal genes
2 sets of paternal genes
no maternal genes
GTD
partial mole consists of …. sets of genes, maternal genes, paternal genes
3 sets of genes
1 maternal sets of genes
2 paternal sets of genes
GTD
complete mole has…. fetus
no fetus
GTD
Partial mole has….. fetus
non- viable fetus
GTD
Fetal embryonic tissue is (present/ absent) in a complete mole
absent
GTD
fetal embryonic tissue is (present/ absent) in complete mole
present - fetus, fetal RBC
GTD
Trophoblastic hyperplasia is …. in complete mole
focal
GTD
trophoblastic hyperplasia is….. in partial mole
diffuse
GTD
Clinical presentation
- Irregular vaginal bleeding, some have passed vesicles
- Uterine size larger than date
- Early failed PG
- Hyperemesis
- Anemia
- Hyperthyroidism
- Early- onset severe pre- eclampsia
- thromboembolism
- large ovarian theca lutein cysts causing abnormal dilatation
- Neurological and respiratory Sx due to brain and lung metastasis
GTD
Reason for hyperemesis
due to increased beta HCG