M.O.D.Y

Question 1

What does M.O.D.Y stand for?

Answer 1

Maturity onset diabetes of the young

=> Type 2-like Diabetes that comes on usually before the age of 25

Question 2

If M.O.D.Y is similar to Type 2 diabetes, do patients require insulin?

Answer 2

No

They are still capable of synthesising and releasing insulin

Question 3

What do the majority of genetic mutations in M.O.D.Y affect?

Answer 3

Glucokinase

Transcription Factors

Question 4

Patients with M.O.D.Y have a lower resting blood glucose than people without diabetes. TRUE/FALSE?

Answer 4

FALSE

they have a HIGHER resting blood glucose

Question 5

When do patients with Glucokinase mutations usually present?

Answer 5

Onset at birth

Question 6

What is the difference between hyperglycaemia in Glucokinase and Transcription factor mutations?

Answer 6

Glucokinase mutations = stable hyperglycaemia through life

Transcription Factor mutations = progressive hyperglycaemia

Question 7

How is a Glucokinase mutation M.O.D.Y treated?

Answer 7

Dietary measures

Question 8

Are complications common or rare in glucokinase mutation M.O.D.Y?

Answer 8

Rare

Question 9

When do Transcription Factor mutation M.O.D.Ys usually present?

Answer 9

Adolescence/young adult onset

Question 10

How are Transcription factor mutation M.O.D.Ys treated?

Answer 10

1/3 diet
1/3 oral hypoglycaemic agents
1/3 Insulin

Question 11

Are complications rare or common in Transcription factor mutation M.O.D.Y?

Answer 11

Common

Question 12

When does neonatal diabetes usually occur?

Answer 12

3-6 months after birth

Question 13

What are the two types of neonatal diabetes?

Answer 13

Transient (Resolves median 12 weeks - Stop insulin)

Permanent (Lifelong insulin)

Question 14

Briefly explain how sulphonylureas work

Answer 14

close K-ATP channel
Membrane depolarised
Calcium influx
Insulin secretion

Question 15

What is the main cause of neonatal diabetes?

Answer 15

Potassium (K-ATP) channel mutations