Modules 1-5 Flashcards
Hypertensive crisis is life-threatening and cannot be reversed unless more MAO is produced by the body: True or False
True
What is a hypertensive crisis?
Hypertensive crisis occurs when MAOIs are taken in conjunction with foods containing tyramine, a dietary precursor to norepinephrine
Hypertensive crisis and death also can occur when MAOIs are taken in conjunction with certain medications. What is a specific medication that can cause this?
Stimulants and other sympathomimetics
Symptoms of HTN crisis. Just read
a. Elevated BP
b. Sudden, explosive-like headache, usually in occipital region
c. Facial flushing
d. Palpitations
e. Pupillary dilation
f. Diaphoresis
Treatment for HTN crisis
a. D/C the offending agent
b. Administer PHENTOLAMINE
Teratogenic risks: Benzos
a. floppy baby syndrome
b. cleft palate
Teratogenic risks: Depakote/Carbamazepine
Neural Tube defect
(Spina bifida for Depakote)
Teratogenic risks: Lithium
Ebstein anomaly (especially in the first trimester)
What age should you check in women for mood stabilizers? And why?
Check pregnancy status before starting females of childbearing age (12-51) on a mood stabilizer - Mood stabilizers increase risk of neural tube defects
What should you encourage if a woman is taking a mood stabilizer? And why?
Encourage Folic Acid (0.4-0.8mg qd) if taking mood stabilizers
This supports neural tube development during the first month that a woman is pregnant.
a. Low BMI
b. Amenorrhea
c. Emaciation (abnormally thin)
d. Bradycardia
e. Hypotension
Anorexia symptoms
Main treatment for anorexia?
Therapy
Recurrent, episodic binge eating
a. Weight usually withing normal range (BMI)
b. Russel’s sign
c. Rectal prolapse
d. Erosion of dental enamel
Main symptoms for Bulimia?
Scarring or calluses on the dorsum of the hand, secondary to self induced vomiting
Russell’s sign?
What medication to consider for chronic neuropathic pain and depression?
SNRI such as Cymbalta – duloxetine
Medication FDA approved for Bulimia?
fluoxetine (Prozac)
Mnemonic for Inducers
BullShit CRAP GPS- Induces my rage
Inducer Medications- Just read and memorize
Barbiturates,
St. John,
Carbamazepine,
Rifampin,
Alcohol,
Phenytoin,
Griseofulvin,
Phenobarbital,
Sulfonylureas.
Other inducers include
Cigarette smoking and Oral contraceptives
Mnemonic for Inhibitors
SICKFACES.COM
Inhibitor Medications- Just read and memorize
Sodium Valproate,
Isoniazid,
Cimetidine,
Ketoconazole,
Fluconazole,
Alcohol,
Chloramphenicol,
Erythromycin,
Sulfonamide,
Ciprofloxacin,
Omeprazole,
Metronidazole
What drug is an atypical antipsychotic drug that is metabolized to a major extent by the CYP450 enzyme CYP1A2?
Clozapine
Where is acetylcholine synthesized in?
Basal of Meynart
What is GABA?
It is a universal inhibitory neurotransmitter and it’s
MOST ABUNDANT INHIBITORY NEUROTRANSMITTER IN THE BRAIN
What is in the amygdala, hippocampus & locus of coeruleus and INCREASES anxiety
Neuropeptides
What is produced in the adrenal glands?
Epinephrine
Increased levels of corticotrophin releasing hormone in the amygdala, hippocampus and locus coeruleus increases what?
Increases symptoms of anxiety
Sensorimotor information exchange between the two hemispheres.
Both hemispheres connected by the Corpus Callosum.
What is the Cerebellum function?
largest and most developed lobe (language expression)
-executive functions (memory, understanding language, problem solving, emotions, behavioral control, decision making)
What is the frontal lobe function?
Where is the Broca’s area located and what does it do?
a. Located in the frontal lobe
b. Function: Expressive speech
What is the Limbic System focuses on?
Emotions and memories
This part of the brain is in charge of:
a. Appetite
b. Sensations of hunger/thirst,
c. Water balance,
d. Circadian rhythms
e. Body temp,
f. libido
g. hormonal regulation
Hypothalamus
(A hungry hippo needs to eat and sleep after sex)
Regulates emotions, memory and related affective behaviors
What does the Thalamus regulate?
The Thalamus contains 5HT2A. What is that?
5HT2A makes an antipsychotic atypical and LESS likely to cause EPS.
The Hippocampus regulates memory: True or false
True: It regulates memory and converts short-term memory into long-term memory
Nigrostriatal pathway: What does the blockage of D2 receptors lead to?
What is decreased D2 lead to?
a. Can lead to EPS (dystonia, parkinsonian symptoms and akathisia)
b. Decreased D2 = increased Acetylcholine
Tardive Dyskinesia- First line of treatment is Cogentin: True or false
False: It can worsen
Tardive Dyskinesia- Reglan (metoclopramide) can cause TD: True or False
True
What medication to use with Tardive Dyskinesia?
Tetrabenazine and VMAT-2 inhibitors (Ingrezza)
What type of medications can worsen both depression and mania?
Steroids
Risk factors for Serotonin Discontinuation Syndrome? (just read)
a. Medications with a short ½ life
b. Abrupt discontinuation
c. Non-compliance
d. High dose range
e. Long-term treatment
f. Prior hx of discontinuation syndrome
Do you stop serotonin medications if a patient has serotonin discontinuation syndrome?
Don’t D/C SSRI, TCA, MAOI abruptly
This disease has acute onset that causes short-term changes in cognition, ALOC, and inattention.
Delirium
One year mortality rate of clients with delirium is how much?
Up to 40%
Treatment for Delirium
a. Haldol
b. AVOID benzos unless the patient is at risk and has not
responded to Haldol.
What type of dementia affect language and memory?
Cortical Dementia
What type of dementia effects depression, apathy, and motor symptoms?
Subcortical Dementia
This disease has a gradual onset / progressive decline.
Alzheimers Dementia
This does not have focal neurological deficits (problems with nerve, spinal cord or brain function)
What is the second most common dementia?
Vascular Dementia
a. Carotid bruits
b. Fundoscopic abnormalities
c. Enlarges cardiac chambers
Hallmarks for Vascular Dementia
Subcortical Dementia is:
HIV Dementia
AVOID Benzos in patients with delirium if at all possible in most patients with dementia as they are particularly vulnerable to their adverse effects such as sedation, falls and delirium
Just read
Decreasing new cases
- prevention
Primary Prevention
-Early case finding
- Screening
Secondary prevention
Avoid or postpone complications (rehabilitative services)
- ALREADY HAS
- Key word: rehabilitation
Tertiary Prevention
The tendency of some regions of the brain to react to repeated low-level bioelectrical stimulation by progressively boosting synaptic discharges, thereby lowering seizure thresholds.
Kindling Definition