Modules 1-5 Flashcards
Hypertensive crisis is life-threatening and cannot be reversed unless more MAO is produced by the body: True or False
True
What is a hypertensive crisis?
Hypertensive crisis occurs when MAOIs are taken in conjunction with foods containing tyramine, a dietary precursor to norepinephrine
Hypertensive crisis and death also can occur when MAOIs are taken in conjunction with certain medications. What is a specific medication that can cause this?
Stimulants and other sympathomimetics
Symptoms of HTN crisis. Just read
a. Elevated BP
b. Sudden, explosive-like headache, usually in occipital region
c. Facial flushing
d. Palpitations
e. Pupillary dilation
f. Diaphoresis
Treatment for HTN crisis
a. D/C the offending agent
b. Administer PHENTOLAMINE
Teratogenic risks: Benzos
a. floppy baby syndrome
b. cleft palate
Teratogenic risks: Depakote/Carbamazepine
Neural Tube defect
(Spina bifida for Depakote)
Teratogenic risks: Lithium
Ebstein anomaly (especially in the first trimester)
What age should you check in women for mood stabilizers? And why?
Check pregnancy status before starting females of childbearing age (12-51) on a mood stabilizer - Mood stabilizers increase risk of neural tube defects
What should you encourage if a woman is taking a mood stabilizer? And why?
Encourage Folic Acid (0.4-0.8mg qd) if taking mood stabilizers
This supports neural tube development during the first month that a woman is pregnant.
a. Low BMI
b. Amenorrhea
c. Emaciation (abnormally thin)
d. Bradycardia
e. Hypotension
Anorexia symptoms
Main treatment for anorexia?
Therapy
Recurrent, episodic binge eating
a. Weight usually withing normal range (BMI)
b. Russel’s sign
c. Rectal prolapse
d. Erosion of dental enamel
Main symptoms for Bulimia?
Scarring or calluses on the dorsum of the hand, secondary to self induced vomiting
Russell’s sign?
What medication to consider for chronic neuropathic pain and depression?
SNRI such as Cymbalta – duloxetine
Medication FDA approved for Bulimia?
fluoxetine (Prozac)
Mnemonic for Inducers
BullShit CRAP GPS- Induces my rage
Inducer Medications- Just read and memorize
Barbiturates,
St. John,
Carbamazepine,
Rifampin,
Alcohol,
Phenytoin,
Griseofulvin,
Phenobarbital,
Sulfonylureas.
Other inducers include
Cigarette smoking and Oral contraceptives
Mnemonic for Inhibitors
SICKFACES.COM
Inhibitor Medications- Just read and memorize
Sodium Valproate,
Isoniazid,
Cimetidine,
Ketoconazole,
Fluconazole,
Alcohol,
Chloramphenicol,
Erythromycin,
Sulfonamide,
Ciprofloxacin,
Omeprazole,
Metronidazole
What drug is an atypical antipsychotic drug that is metabolized to a major extent by the CYP450 enzyme CYP1A2?
Clozapine
Where is acetylcholine synthesized in?
Basal of Meynart
What is GABA?
It is a universal inhibitory neurotransmitter and it’s
MOST ABUNDANT INHIBITORY NEUROTRANSMITTER IN THE BRAIN