Medications

Question 1

What is clozapine metabolized by?

Answer 1

Cytochrome P450 enzyme aka CYP1A2.

Question 2

This decreases the serum level of other drugs that are substrates of that enzyme.
This can cause subtherapeutic drug level

Answer 2

Enzyme inducer definition

Question 3

If a patient is taking olanzapine and smoking tobacco then increase the dose of the medication.
If quitting smoking = decrease dose of medication.

Answer 3

Enzyme Inducer example

Question 4

This increases the serum level of other drugs that are substrates if that enzyme.
This can lead to toxic levels.

Answer 4

Enzyme Inhibitor definition

Question 5

Steroids can cause psychosis: true or false

Answer 5

True 👍

Question 6

First-generation antipsychotics are called:

Answer 6

Typical antipsychotics

Question 7

Second-generation antipsychotics are called:

Answer 7

Atypical antipsychotics

Question 8

serotonin (5HT2A) + dopamine antagonist

Answer 8

Second generation antipsychotic

Question 9

Why do we use atypical antipsychotics first?

Answer 9

Less likely for EPS but cause more weight gain.

Question 10

First generation antipsychotics risks

Answer 10

Higher incidemce of EPS

Question 11

When a patient has increased risk for DTO/DTS when psychotic, you have to stabalize ASAP. What is one thing you can do to achieve this?

Answer 11

Use IM Invega (paliperidone), geodon, or Abilify.

Question 12

Treatment for EPS symtoms

Answer 12

First line - Beta-blocker
Second line- Benztropine (anticholinergic)
Third line- clonazepam (use with care)