Module Five Flashcards
Three components of internal validity?
Chance, bias, confounding
Components of chance to identify?
95% confidence interval (sample size), Null value, Clinical vs Statistical significance
What does increasing the sample size do?
Reduces sampling variability, increases likelihood of getting a representative table and increases precision of parameter estimate
What do you do if the p-value is below 0.05?
Reject the null
How do you interpret a confidence interval?
x times as likely… we are 95% confident that… and since p-value is less than 0.05 the association is statistically significant, we reject null, unlikely due to chance…
What is a type 1 error?
Rejects a null hypothesis that is actually true
What is a type 2 error?
Failing to reject the null hypothesis when it’s actually false
If a CI includes the null?
p-value > 0.05, fail to reject null, findings not statistically significant
If a CI does not include the null?
p-value < 0.05, reject null, findings statistically significant
What are p-values problemtatic?
Arbitrary threshold, only about Ho, nothing about importance
What is bias?
Any systematic error in an epidemiological study that results in an incorrect estimate of the association between exposure and risk of disease
Three types of bias?
Selection bias, Information bias, Publication bias
What can bias cause?
Precision parameter being bias towards or away from the null, causing an over/under estimation
When can selection and information bias be controled?
Only in design phase
When can publication bias be controled?
Only in analysis phase
How do you minimise loss to follow up?
Alternative contact, regular contact and several attempts at contact
How can you minimise recall bias
Objective measures, validate self-reported measures with other information, memory aids
How can you minimise interviewer/observer bias?
Clearly define study protocol and measures, structure questionnaire and standard prompts, training of interviewers, blinding
What are the requirements for something to be a confounder?
Independently associated with exposure, Independently associated with outcome, not on the causal pathway
What is an overestimation?
RR is further from null
What is an underestimation?
RR is closer to null
How can you control for a confounder in the design stage?
Randomisation, Matching, Restriction (to a strata)
How can you control for a confounder in the analysis stage?
Stratification, Multivariable analysis, Age standardisation
What are the pros of stratification?
Easy for a small number of potential confounders with limited strata, can evaluate impact of confounding, can identify effect modification
