Module 7 Flashcards
What is the body’s first line of defence?
Preformed adaptations which inhibit pathogens from entering the body.
This includes:
- Skin
- Mucous membrane
- Cilia
- Chemical barriers
- Secretion
How does the skin inhibit pathogens entering the body?
- Tightly packed cells form a protective layer
- Pores secrete anti-microbial fluids that inhibit surface growth of bacteria 🦠
Innate immune system definition
The body’s first response to a pathogen. it provides a non specific protection by responding in a generic manner
No immunological memory
How does the mucous membrane prevent pathogens from entering the body?
Mucous lines the respiratory, urinary and reproductive tract that traps pathogens and foreign particles.
Adaptive immune system definition
A specialised protection against pathogens which enter the body it is highly specific but needs time to develop a primary response. It has immunological memory so upon second exposure it is faster and stronger
There are two main classes of cells :
B cells and T cells
How does cilia prevent pathogens from entering the body?
Cilia are hair-like projections that like the nose and throat. They ‘wave’ at 12 beats/s to move mucous up the tract.
Describe features of a prion and give and example.
A mis-folded protein that spreads through transmission of its abnormality onto normal variants of the same protein - causing several neurodegenerative diseases in humans.
E.g. mad cow disease
How do chemical barriers stop pathogens from infecting the body?
- Stomach acids and enzymes in the mouth create uninhabitable conditions for bacteria.
- Enzymes called lysozymes dissolve cell membranes, killing the pathogen.
What are B cells and where are they created
They are apart of the adaptive immune system and they produce antibodies responsible for antibody- meditated immunity
They mature in the bone marrow developing from hematopoietic stem cells
There are two types: plasma cells and memory B cells
List the defining features of a virus and give an example
- non-cellular
- consist of a nucleus acid (DNA or RNA) Surrounded by a protein coat
- replicates inside living cells
E.g. HIV, Measles
How do bodily secretions prevent pathogens from entering the body?
Sweat glands, hair follicles and open passages in the body secrete chemicals that destroy bacteria and fungi as well as flushing reservoirs where pathogens may hide.
What is the body’s second line of defence?
Adaptive response systems that actively fight pathogens to stop the progression of disease and is only activated once the pathogen has breached the first line of defence.
What type of pathogen is a single called eukaryotic organism and how does it cause infection ?
Give an example of an infection.
Protozoa
They absorb nutrients from hosts ( heterotrophic)
-secrete toxins
- invade cells
- form biofilms ( colonies ) which affect cell and tissue function
E.g. malaria
How does the lymph system respond to pathogens?
- Lymphatic vessels/nodes, the spleen and the thymus produce WBCs.
- WBCs activate the immune response and once the pathogen has been drained to the lymph nodes they are killed.
B cell types (2) and what they do
Plasma cells: (immediate protection) a WBC that makes large amounts of specific antibodies
Memory B cells: (persistent protection) create more rapid responses upon secondary antigen detection
How do histamines respond to pathogens?
Histamines increase the permeability of of blood vessels (inflammation) to allow blood to easily travel to the site of infection.
This helps clear out dead cells, initiate tissue repair and increase temperature to deactivate pathogens.
Antigen vs Antibodies
Antigens are any foreign substance that enters your body and an antibody is what the immune system produces to fight of the antigen
What are phagocytes?
Specialised WBCs, macrophages and neutrophils that engulf pathogens and break them down.
List the defining features of bacteria and give an example of a infection caused by bacteria
- single celled prokaryotic organism
- no nucleus
- reproduction through binary fission
- causes infection through secretion of toxins, invasion of cells, formation of biofilms ( Colonies)
E.g salmonella, tuberculosis
List the characteristics of fungal pathogens and give an example of a infection they cause.
- eukaryotic organism
- heterotrophic
- has cell walls
- take in nutrients from environment through secretion of digestive enzymes
- reproduction through spreading spores that can release harmful enzymes
E.g thrush, ringworm