Module 6: Non-Malignant Leukocyte Disorders

Question 1

Classification of non-malignant leukocyte disorders

Answer 1

Quantitative disorders: Leukocytosis and Leukopenia

Acquired Disorders: Infectious disease and immune disorders

Question 2

Luekocytosis

Answer 2

Neutrophilia
Lymphocytosis
Monocytosis
Eosinophilia
Basophilia
Leukemoid reactions

Question 3

Leukopenia

Answer 3

Neutropenia (agranulocytosis)
Lymphocytopenia
Eosinopenia

Question 4

Infectious diseases

Answer 4

whooping cough
infectious lymphocytosis
rubella
infectious mononucleosis

Question 5

Immune disorders

Answer 5

Lupus erythematosus

Question 6

Morphological changes of Reactive lymphs

Answer 6

Nuclear shape: Oval, notched, indented, elongated (indented by other cells)
Chromatin: Irregular clumping, parachromatin more apparent
One or more nucleoli present
Increased cytoplasm volume (edges may be scalloped)
Vacuoles and azurophilic granules may be present

Question 7

Morphological changes of Reactive neuts

Answer 7

Basophilia of cytoplasm
Toxic granulation
Doyle bodies
Vacuolation
Hyper segmentation

Question 8

Difference between relative and absolute lymphocytosis

Answer 8

Relative: Increase in # of lymphs per 100 cells counted

Absolute: increase in number of lymphs per L of blood

Question 9

Which is more significant: Relative or absolute lymphocytosis

Answer 9

absolute

Because it indicates quantitatively how many lymphs are available in the blood to counter infections

Question 10

When changes in leukocytes are produced by non-malignant disorders, the cells are called

Answer 10

reactive or variant

Question 11

Reactive changes produced in leukocytes by non-malignant disorders

Answer 11

Shift to the left
Leukopenia due to damage to areas of production or enhanced destruction of mature cells
Morphological changes producing reactive lymphs and granulocytes