Module 4: Normocytic Anemias

Question 1

Pancytopenia

Answer 1

decreased number of all cellular elements in the blood

Question 2

Aplastic anemia

Answer 2

depletion of cellular elements and fatty replacement of BM

Results in pancytopenia and hypoplasia

Question 3

Inherited aplastic anemia

Answer 3

less than 1% of cases
Fanconi’s anemia (autosomal recessive disease)
-developmental abnormalities

Question 4

Acquired aplastic anemia

Answer 4

99% of cases

Primary (idiopathic, 50% of cases) and secondary

Question 5

secondary acquired aplastic anemia

Answer 5

due to damage of blast cells or stem cells

Due to: Chemical agents, drugs, insecticide, ionizing radiation, infections

Question 6

Lab findings for aplastic anemia

Answer 6

decreased: RBC, hct, hb, WBC, PLT

Pancytopenia, hypoplasia

Question 7

Post hemorrhagic anemia

Answer 7

normochromic, normocytic anemia due to acute blood loss

Question 8

3 stages of development for post hemorrhagic anemia

Answer 8

24hrs later: little evidence of anemia, HB, RBC and HCT remain normal

24-72hrs: Normochromic normocytic anemia is present. HB, RBC, HCT all decrease

72hr +: Normochromic regenerative anemia occurs (reticulocytosis)