Module 5 Flashcards
Why is sexual reproduction important?
- produces offspring that are genetically different to their parents
- generates variation within population
How is sexual reproduction expensive for animals?
- production of gametes
- production of pheromones
- cost of finding a mate
- competition b/w males
sex determination
- embryonic gonads form that could either become testes or ovaries
- the presence or absence of SRY gene decides which developmental pathway is followed
- this gene codes for TDF (a gene regulation protein)
- by binding to specific DNA sites, TDF stimulates the expression of genes for testis development
- found on Y chromosome
The gonads (testes & ovaries) produce which 3 major steroid sex hormones?
- androgens (principally testosterone)
- oestrogens (principally oestradiol)
- progesterone
- cholesterol is their precursor
primary sex characteristics
reproductive structures that develop in the embryo
- penis, testes, seminal vesicles, associated ducts
- ovaries, fallopian tubes uterus, vagina
- brain sex
ovaries
eggs mature in & are released by the ovaries (produces eggs, estrogen, & progesterone)
oviducts
collects eggs at ovulation, provides a site for fertilization then moves the embryo to the uterus
uterus
provides protection, food, oxygen and removal of waste products for the fetus during pregnancy
- blastocyst implants in the ENDOMETRIUM of the uterus
cervix
neck of the uterus which protects the fetus during pregnancy and then dilates to provide a birth canal
vagina
stimulates penis to cause ejaculation & provides a birth canal
What is folliculogenesis
development of the follicle (follicle includes egg, fluid accumulation, theca cells, granulosa cells)
Oogenesis
- mitosis - oogonium
- growth –> primary oocytes
- primary oocyte & its surrounding cells = follicle
- meiosis I - stops at prophase I –> primary follicle
- at menstrual cycle, meiosis I is finished –> large secondary oocyte + unequal division of cytoplasm (2 haploid nuclei)
- meiosis II –> stops in prophase II
- ovulation = follicle ruptures, releasing oocyte
- the remaining follicle cells form the corpus luteum, which produces progesterone + estrogen
- after FERTILIZATION, secondary oocyte completes 2nd division of meiosis to form an ovum (one set of chromosomes - haploid)
estrogen
- produces by granulosa cells in follicle
- acts via estrogen receptors
- regulates oviduct (Fallopian tube), uterus, cervix, vagina, & other sex organs
- prepares endometrium for implantation (increases vascularization, blood supply)
- promotes oestrus (or mating) behaviour
progesterone
- produced by corpus luteum
- acts via progesterone receptors
- regulates oviduct, uterus, cervix, vagina, & other sex hormones
- prepares endometrium for implanation
- modulates effects of estrogen, STOPS follicle growth
Menstruation
- elimination of the thickened lining of the uterus (endometrium) from the body via the vagina
- menstrual fluid: consists of blood, lining of the uterus, & uterine mucus
Hypothalamo-pituitary-gonadal axis (HPG axis)
- hypothalamus secretes gonadotropin releasing hormone (GnRH) that acts on anterior pituitary
- GnRH release is in pulses
- anterior pituitary produces gonadotrophins (FSHH & LH)
LH - luteinizing hormone
- stimulates theca cells to produce androgens
- a surge in LH stimulates ovulation
- stimulates formation of corpus luteum
what are theca cells?
Theca cells are a group of endocrine cells in the ovary made up of connective tissue surrounding the follicle. They have many diverse functions, including promoting folliculogenesis and recruitment of a single follicle during ovulation.
FSH - follicle stimulating hormone
- stimulates folliculogenesis
- acts on granulosa cells to stimulate the conversion of androgens to estrogens
what are granulosa cells?
Granulosa cells are a type of cell in your ovaries that produce hormones including estrogen and progesterone. Hormones released from the base of your brain (anterior pituitary) control the numbers and function of granulosa cells
When is the follicular phase?
days 1 - 14 (maturation of follicle)
when is the luteal phase?
days 14 - 28 (preparation for implantation)
What is endometriosis?
- affects 10% of women
- endometrial cells grow in other PARTS of body (eg around ovaries, bladder, rectum)
- severe abdominal pain & infertility
- endometrial cells have estrogen & progesterone receptors
What will happen to this endometrial tissue (outside endometrium) during the menstrual cycle?
- In response to hormones in the menstrual cycle the endometrial cells outside the uterus GROW in response to progesterone
- Shed into the pelvic cavity when the progesterone levels drop