Module 4 Section 1: Disease and the Immune System Flashcards
What is a disease
A condition that impairs the normal functioning of an organism
Can affect plants and animals
What is a pathogen
An organism that causes a disease
What are the different types of pathogens
Bacteria
Viruses
Fungi
Protoctista
Prion (don’t need to know)
What is a communicable disease
A disease that can spread between organisms
Diseases caused by bacteria
Tuberculosis (TB)
Bacterial meningitis
Ring rot
Diseases caused by viruses
HIV/AIDS
Influenza
Tobacco mosaic virus
Diseases caused by fungi
Black Sigatoka
Ringworm
Athletes foot
Diseases caused by a protoctist
Potato/tomato late blight
Malaria
Tuberculosis (TB)
Bacterium
Affects animals typically humans and cattle
Caused by bacterium mycobacterium tuberculosis
Damages and destroys lung tissue and suppresses immune system
Curable by antibiotics and preventable by improving living conditions
Bacterial meningitis
Bacterium
Affects humans
Caused by streptococcus pneumoniae or neisseria meningitidis
Affects meninges of the brain (protective membranes of brain surface) which can spread to rest of the body causing blood poisoning (septicaemia)
Cured by antibiotics if delivered early
Ring rot
Bacterium
Affects potatoes, tomatoes
Caused by clavibacter michiganensis
Damages leaves, tubers and fruit
HIV/AIDS
Virus
Affects humans
Pathogen called Human Immunodeficiency Virus
Disease: Acquired Immunodeficiency Syndrome (AIDS)
Destroys immune system so people are vulnerable to other diseases
Passed through exchange of body fluids (sex) and blood (needles)
No vaccine or cure but drugs can slow progress of disease
Influenza
Virus
Affects animals including humans
Caused by orthomyxoviridae spp
Attacks and kills ciliated epithelial cells leaving them open to secondary infection
No cure but people can be vaccinated annually
Tobacco mosaic
Virus
Affects tobacco plants, tomatoes, peppers, cucumbers, petunias
Caused by Tomabovirus (?)
Damages leaves, flowers, fruit
Stunts growth and reduces yield
No cure
Black Sigatoka
Fungi
Affects banana plants
Caused by mycophaerella fijiensis
Attacks and destroys leaves turning them black
No cure but fungicide can be used to control spread
Ringworm
Fungi
Affects cattle
Caused by Trycophyton verrucosum
Causes grey-white, crusty circular areas of skin in cattle
Cured using antifungal creams
Athlete’s foot
Fungi
Affects humans
Caused by Tinia Pedia
Grows on and digests warm, moist skin between toes causing cracking and scaling which can be itchy and sore
Cured using antifungals creams
Malaria
Protoctist
Affects animals including humans
Caused by Protoctista plasmodium spread by bites of infected mosquitoes (vector)
Invades red blood cells, liver and brain
No vaccine and limited cures
Potato/tomato blight
Protoctist
Affects potatoes and tomatoes
Oomycete phytophthora
Destroys leaves, tubers and fruit
No cure
How can communicable diseases be transmitted
Directly transmission
Indirectly transmission
How are diseases spread by direct transmission
When a disease is transmitted directly from one organism to another
Can be done through:
Direct contact
Inoculation
Ingestion
How are diseases spread directly by contact
Contact with body fluids of another person
E.g. bacterial meningitis or STIs
Direct skin to skin contact
E.g. ring worm, athletes foot
Microorganisms from faeces transmitted on hands
E.g. diarrhoeal diseases
How can diseases be transmitted indirectly
When a disease is transmitted from one organism via an intermediate
Intermediates include:
Fomites
Droplet infection
Vectors
Examples of disease that can be transmitted indirectly
Potato/tomato late blight is spread when spores are carried between plants - first in the air , then in the water
Malaria is spread between animals via mosquitoes
Mosquitoes act as vectors - they don’t cause malaria themselves, they just spread the Protoctista that cause it
What conditions can affect disease transmission
Living conditions
Climate
Social factors
How can living conditions affect disease transmission
Overcrowded living conditions increase the transmission of many diseases
E.g. TB is spread directly via droplet infection, can also be spread indirectly because the bacteria can remain in the air and infect new people so the risk of infection is increased when lots of people live crowded together
How can climate affect disease transmission
Potato/tomato late blight is especially common during wet summers because the spores need water to spread
Malaria is most common in tropical countries, which are humid and hot
This is because these are the ideal conditions for mosquitoes to breed
How can social factors affect how disease is spread in humans
Risk of HIV infection is high in places where there’s limited access to:
Healthcare: people are less likely to be diagnosed and treated for HIV and anti-HIV drugs are less likely to be available, so the virus is more likely to be passed on to others
Health education: to inform people about how HIV is transmitted and how it can be avoided (e.g. through safe sex practices like using condoms)
How can bacteria be classified
By their shape
By their cell wall
What are the different shapes available for bacteria
Bacillus/ chain of bacilli (rod)
Coccus/ pair, chain or cluster (sphere)
Vibrio (comma)
Spirillum (spiral)
Spirochaete (corkscrew)
How to test for the different types of bacterial cell wall
Gram staining
Different structures of cell wall react differently with the stain
Results of gram staining for bacteria
Gram positive appear purple/blue under light microscope
Gram negative appear red under light microscope
How can different types of cell walls affect how bacteria are treated
The type of cell wall affects how bacteria react to different antibiotics
How do bacteria reproduce
Binary fission
Characteristics of viruses
Protein shell
Genetic information as RNA or DNA
0.02-0.3 micrometers
No organelles
Rapidly evolve
Non living
Always pathogenic
How do viruses replicate
Invade other cells using attachment proteins
Hijack biochemistry of the cell
Insert viral DNA into host DNA
Host cell transcribes and translates viral DNA
Host cell copies viruses
How do the different pathogens damage the body
Viruses: hijack and destroy cells
Bacteria: produce toxins
Protists: digest cell contents
Fungi: saprotrophic feeding and digestion of cells
What are protists
Eukaryotes
Single celled or colonies
Parasitic
Often require vector
Do not fall into any other categories
What are fungi
Multicellular
Fungi can be saprophytes: feed on dead organisms
Fungi can be parasitic: pathogenic fungi which causes disease
Fungi reproduce by making millions of spores which can spread
How do fungi feed
Saprotrophic feeding
Secrete enzymes onto surface of food
Extracellular feeding
Enzymes digest food leaving nutrients
Fungi absorbs nutrients left by enzymes
How to prevent malaria
Preventative measures can be used such as mosquito nets, window and door screens and long sleeves to prevent bites
Preventative measures also include controlling the vector by using insecticides and removing standing water
How are diseases spread directly by inoculation
Through a break in the skin
E.g. during sex (HIV)
From an animal bite
E.g. rabies
Through a wound or through sharing needles
E.g. septicaemia
How are diseases spread directly by ingestion
Taking in contaminated food or drink, or transferring pathogens to the mouth from the hands
E.g. dysentery, diarrhoeal diseases
How are diseases spread indirectly by fomites
Inanimate objects such as bedding, socks or cosmetics can transfer pathogens
E.g. athletes foot
How are diseases spread indirectly by droplet infection
Droplets of saliva and mucus enter the air through talking, coughing or sneezing
If they contain pathogens and are breathed in by people then they can become infected
E.g. influenza, tuberculosis
How are diseases spread indirectly by vectors
Vectors transmit communicable pathogens from one host or another
These are often but not always animals
E.g. mosquitoes (malaria), rat fleas (plague)
Water can also act as a vector of disease
How are plant diseases spread by direct transmission
Direct contact of a healthy plant with any part of a diseased plant
E.g. ring rot, TMV, tomato and potato blight and black sigatoka
How are plant diseases spread by indirect transmission
Soil contamination
Vectors
How is plant disease spread by soil contamination
Infected plants often leave pathogens or reproductive spores from protoctista or fungi in the soil
These infect the next crop
E.g. black sigatoka spores, ring rot bacteria and TMV
How is plant disease spread by vectors
Wind: pathogens can be carried by the wind
Water: spores swim in the surface film of water on leaves
Animals: insects and birds carry pathogens and spores from one plant to another as they feed
Humans: pathogens and spores are transmitted by hands, clothing, fomites, farming practices and through transporting plants around the world
Factors that affect the transmission of communicable diseases in plants
Planting crops that are susceptible to disease
Over crowding plants
Poor mineral nutrition reduces resistance of plants
Damp, warm conditions increase the survival and spread of pathogens and spores
Climate change causing increased rain and wind promotes the spread of disease, changing conditions allow animal vectors to spread to new areas
How do plants recognise and respond to pathogens
Receptors in plant cells respond to molecules from the pathogens or to chemicals produces when the plant cell wall is attacked
The stimulates the release of signalling molecules that switch on genes in the nucleus
This triggers cellular responses such as:
Producing defensive chemicals
Sending alarm signals to unaffected cells to trigger their defences
Physically strengthening cell walls
Physical defences of plants
Waxy cuticles: provide barrier against pathogen entry and stops water containing pathogens from collecting on leaf
Cell walls: physical barrier against pathogens that make it through waxy cuticle
Plant produce callose: makes it harder for viruses to spread and enter cells
Functions of callose
Synthesised within minutes of the attack and is deposited between the cell walls and cell membrane in cells next to the infected cells
These callose papillae act as barriers to prevent the pathogens entering the plant cells around the site of infection
Large amounts of callose continue to be deposited in cell walls after the initial infection
Lignin is added to make the mechanical barrier to invasion thicker and stronger
Blocks sieve plates in the phloem, sealing off the infected part and preventing the spread of pathogens
Deposited in the plasmodesmata between infected cells and their neighbours, sealing them off from the healthy cells and helping to prevent the pathogen from spreading
How do plants use chemicals to defend against pathogens
Plants produce powerful chemicals to either repel insect vectors of disease or kill invading pathogens
How can plant chemical defences be utilised by humans
These chemicals can be used by humans to help control insects, fungi and bacteria
Examples of chemicals used in plant defence
Insect repellants: pine resin
Insecticides: caffeine
Antibacterial compounds (including antibiotics): defensins
Antifungal compounds: chitinases
Anti-oomycetes: glucanases
General toxins: cyanide
How do plants respond to pathogen infection internally
Waxy cuticle thickens
Cell walls get stronger
Guard cells close stomata in the leaf
If microbes are attacking one section of the plant, the surrounding cells self destruct to quarantine the infection
How do animals prevent pathogens getting into the body
Animals have a range of primary, non specific defences to prevent pathogens entering the body
How does skin act as a defence against pathogens
Physical barrier
Blocks pathogens from entering body
Can act as chemical barrier by producing chemicals that are antimicrobial and can lower pH to inhibit the growth of pathogens
Has skin flora of healthy microorganisms that outcompete pathogens for space on body surface
Produces sebum, oily substances that inhibits growth of pathogens
How do mucous membranes act as a defence against pathogens
Protect body openings that are exposed to the environment (e.g. mouth, nostrils, ears, genitals and anus 👅)
Some membranes secrete mucus - sticky substance that traps pathogens and contains lysozymes and phagocytes