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HEMATOLOGY MODULE 1 & 2 > MODULE 4 RBC MORPHOLOGY > Flashcards

MODULE 4 RBC MORPHOLOGY Flashcards

1
Q

Qualitative assessment of RBC morphology includes:

A

Size
Shape
Examination and grading of abnormalities
Red cell distribution
Staining
Inclusions

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2
Q

What is RBC Morphology

A

used in diagnostic considerations for anemia and other systematic diseases.
Include in CBC or requested as PBS

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3
Q

Nomenclature of Erythrocytic Stage of Maturation in NORMOBLASTIC

A

Pronormoblas
Basophilic Normoblast
Polychromatophilic Normoblast
Orthochromic Normoblast
Reticulocyte
Erythrocyte

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4
Q

Nomenclature of Erythrocytic Stage of Maturation in RUBRIBLASTIC

A

Rubriblast
Prorubricyte
Rubricyte
Metarubricyte
Reticulocyte
Erythrocyte

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5
Q

Nomenclature of Erythrocytic Stage of Maturation in ERYTHROBLASTIC

A

Proerythroblast
Basophilic Erhtroblast
Polychromatophic Erythroblast
Orthochromic Erythroblast
Reticulocyte
Erythrocyte

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6
Q

Stages of RBC Maturation Cell Stage, Diameter, N/C Ratio and Length of Time

A

Pronormoblast- 12-20 um(micrometer)- 8:1 -24 hrs.
Basophilic Normoblast- 10-15 um- 6:1- 24 hrs.
Polychromatophic Normoblast- 10-12 um- 4:1- 30 hrs.
Orthochromic Normoblasy- 8-10 um- 1:2- 48 hrs.
Reticulocyte- 8-10 um- no nucleus- 24-48 hrs. 2-3 days in BM and 1 day in Peripheral Blood
Erthrocytes- 7-8 um- no nucleus- 120 days.

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7
Q

Explain PRONORMOBLAST
Nucleus
Chromatin
Cytoplasm

A

Nucleus: 1-3 nucleoli
Chromatin: Fine and Uniform
Cytoplasm: Deep blue with no granules

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8
Q

Explain BASOPHILIC NORMOBLAST
Nucleus
Chromatin
Cytoplasm

A

Nucleus: Centrally located with 0-1 nucleoli
Chromatin: Coarsening “wheel spoke pattern of chromatin”
Cytoplasm: Less blue but intensely basophilic
Detected in Hb synthesis occurs

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9
Q

Explain POLYCHROMATOPHILIC NORMOBLAST
Nucleus
Chromatin
Cytoplasm

A

Nucleus: Eccentric with no nucleoli
Chromatin: Show significant clumping
Cytoplasm: “polychromasia” gray-blue or violet-blue cytoplasm
Last stage capable of cell division
Can be seen in circulation
Start of Hb production

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10
Q

Explain ORTHOCHROMIC NORMOBLAST
Nucleus
Chromatin
Cytoplasm

A

Nucleus: Eccentric, full condense no nucleoli
Cytoplasm: Pale blue to Salmon Pink
Last nucleated stage, extruded nucleus, engulfed by BM macrophages

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11
Q

Explain RETICULOCYTES
Nucleus
Chromatin
Cytoplasm

A

Stays 2-3 days in BM and 1 day in the circulation
Nucleus: None
Cytoplasm: Contain basophilic reticulum of RNA on supravital stains
Mixed pink and blue staining on Wright’s stain
Polychromatophilic in Supravital Stain
End of Hb production

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12
Q

Explain ERYTHROCYTES
Nucleus
Chromatin
Cytoplasm

A
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13
Q
A
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HEMATOLOGY MODULE 1 & 2 (3 decks)

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