Module 4: Non-Protein Nitrogens Flashcards
Urea
Excretory product of amino acid catabolism; formed from ammonia in the liver
Urea reference range
2.5 - 8.5mmol/L
Creatinine
Waste byproduct of the dehydration of creatine and the hydrolysis of creatine phosphate in neurons and muscle cells
Uric acid
Major end product of purine metabolism (components of nucleotides, nucleosides and nucleic acids)
How can interference from non-creatinine chromogens be reduced using a kinetic Jaffe method?
By monitoring the change in A over time. Interfering compounds react at different rates and times than creatininie. The differential reaction rates are used to identify creatinine from interferences
Creatinine clearance can be used as an indicator of:
Glomerular filtration rate
Reference range for creatinine clearance
1.20 - 2.30 mL/sec
Formula for calculation of creatinine clearance
CC = U x V x 1.73 / P x 86400 x A