Module 4: Non-Protein Nitrogens Flashcards

1
Q

Urea

A

Excretory product of amino acid catabolism; formed from ammonia in the liver

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2
Q

Urea reference range

A

2.5 - 8.5mmol/L

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3
Q

Creatinine

A

Waste byproduct of the dehydration of creatine and the hydrolysis of creatine phosphate in neurons and muscle cells

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4
Q

Uric acid

A

Major end product of purine metabolism (components of nucleotides, nucleosides and nucleic acids)

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5
Q

How can interference from non-creatinine chromogens be reduced using a kinetic Jaffe method?

A

By monitoring the change in A over time. Interfering compounds react at different rates and times than creatininie. The differential reaction rates are used to identify creatinine from interferences

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6
Q

Creatinine clearance can be used as an indicator of:

A

Glomerular filtration rate

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7
Q

Reference range for creatinine clearance

A

1.20 - 2.30 mL/sec

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8
Q

Formula for calculation of creatinine clearance

A

CC = U x V x 1.73 / P x 86400 x A

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