Module 4 (Microbiology) Overview Flashcards
Bacterial Genome
Single cellular chromosome
No nuclear membrane
Plasmids
Trophic Groups
Photoautotrophs
Photoheterotrophs
Chemoautotrophs
Chemoheterotrophs
Infection Cycle
- Attach
- Penetrate
- Uncoat
- Gene expression and genome replication
- Assembly
- Release
Types of horizontal gene transfer
Transformation
Transduction
Conjugation
Prokaryotic cell components (bacteria)
Nucleoid Cell wall Flagella Endopores Adherence factors (Fimbriae, Pili and glycocalyx - capsule or slime layer)
Growth requirements
Carbon
Energy
Reducing power
Growth phases in culture system
Lag phase
Exponential phase
Stationary phase
Death phase
Human gut microflora
Firmicutes
Bacteroidetes
Actinobacteria
Proteobacteria
Virus Components
Genetic material
Capsid
+ some have envelope otherwise classed as ‘naked’
Attributes transferred through horizontal gene transfer
Virulence factors (attributes that help the bacteria survive in host) Antibiotic resistance (attributes that reduce the effectiveness of antibiotics against targeted bacteria)
Medically Important Pathogens
Bacteria Viruses Fungi Protozoa Helminths
Microbial Pathogenesis
Adherence
Invasion
Replication
Disease
Antibiotic Resistance
Selection for mutants
Gene transfer
How to reduce antibiotic resistance
Decrease antibiotic utilisation
Improve diagnostics
Identify new targets
Combine therapies
Chain of Infection
Causative agent Reservoir Means of exit Mode of transmission Portal of entry Person at risk