Module 4 - Biodiversity, Evolution and Disease Flashcards
Active immunity
Resistance in an organisms that has developed through production of specific antibodies in response to pathogen. Provides long-lasting immunity as memory cells are produced
Agglutinins
Chemicals that cause pathogens to aggregate together, aiding phagocytosis. Antibodies can act as agglutinins
Antibiotic
Chemical/compound produced by living organism that kills/prevents growth of bacteria
Antibiotic-resistant bacteria
Bacteria that mutate to become resistant to an antibiotic, survive & reproduce rapidly, passing on their antibiotic resistance
Antibodies
Immunoglobulins produced by B-lymphocytes in response to specific antigen, triggering immune response
Antigen
Chemical presents on surface of cell that induces an immune response
Antigen-presenting cell
Macrophage that displays foreign antigens
Anti-toxins
Chemicals produced by white blood cells that neutralise toxins released by pathogens
Artificial active immunity
Production of antibodies by immune system following exposure to weakened attenuated/dead pathogens e.g. vaccination
Artificial passive immunity
Immunity acquired from the administration of specific antibodies from another organisms e.g. vaccination
Athlete’s foot
Form of ringworm in humans, affects feet, cracking and scaling of the skin
Autoimmune disease
Condition which the immune system attacks & destroys healthy body tissue e.g. arthritis
Bacteria
Prokaryotic cells that have cell walls but lack organelles, some bacteria are pathogenic, producing toxins that damage host cells
Bacterial meningitis
Severe form of meningitis caused by bacterial infection of meninges, complications of bacterial meningitis include septicaemia, symptom of this rash of purple discolouration that doesn’t fade when a glass is pressed against it
B effector cells
Type of B lymphocyte that divides to form plasma cells
Black sigatoka
Fungal disease in tomatoes cause by Mycosphaerella fijiensis hyphae of which penetrate & digest host leaf cells turning them black
B lymphocytes
Lymphocytes that mature in bone marrow, 3 main types, plasma cells, B effector cells & B memory cells
B memory cells
B lymphocytes that provide immunological memory
Callose
Plant polysaccharide contains β-1,3 & β-1,6 linkages between glucose molecules, it is deposited between the cell walls & cell membrane in cells adjacent to infected cells serving as defence again pathogens, also found in cell walls of infected cells & plasmodesmata between infected cells
Chitinases
Enzymes that degrade chitin in fungal cell walls
Clonal expansion
Mass proliferation of specific antibody-producing cells
Clonal selection
Identification of an antibody-producing cell with complementary receptors to the shape of specific antigen
Clostridium difficile
Type of bacteria found in gut of some individuals which is resistant to most antibiotics
Communicable disease
Disease that is caused by pathogen & transmitted directly between organisms
Cytokines
Cell-signalling molecules produced by mast cells in damaged tissue, attract white blood cells to site of damage
Direct transmission
Transfer of a pathogen directly from 1 organism to another, can occur via direct contact/ingestion/sharing contaminated needles
Epidemic
Rapid rise in incidence of communicable disease at local/national level
Expulsive reflexes
Coughs/sneezes initiated upon irritation of respiratory tract, remove microorganism-containing mucus from gaseous exchange system
Fungi
Eukaryotic,. Digest & destroy cells & produce spores that can spread rapidly between organisms
Glucanases
Enzyme produced by plants that decompose glucans, polysaccharides found in oomycete cell walls
Histamine
Chemical produced by mast cells in damaged tissue, makes blood vessels dilate & cause their walls to become leakier
Human Immunodeficiency Virus (HIV)
Infectious virus that destroys T helper cells, weakening immune system of body. HIV makes an individual more susceptible to opportunistic infections & can lead to AIDS
Indirect transmission
Transfer of pathogen organisms via fomites/vectors/droplet infection/soil contamination
Inflammation
Localised response of vascular tissue to pathogens/damage/irritants, characterised by pain/redness/heat/swelling
Influenza
Common vital infection caused by family of viruses, Orthomyxoviridae, destroys ciliated epithelial cells in gaseous exchange system, exposing airways to secondary infection
Interleukins
Cytokines produced by T helper cells that stimulate B cells
Lymphocytes
White blood cells that contribute to the specific immune response
Lysosome
Membrane-bound organelles that contain hydrolytic enzymes
Malaria
Disease caused by protoctista Plasmodium, lives within 2 hosts, mosquitoes & humans, causes recurrent episodes of fever, can be fatal
Mast cells
Specialised cells in connective tissue that are important in the inflammatory response, releasing histamines & cytokines
MRSA
Type of bacteria that is resistant to the antibiotic methicillin
Mucous membranes
Membranes lining body cavities that secrete a sticky mucus
Natural active immunity
Production of antibodies by immune system following infection
Natural passive immunity
Immunity acquired by infant mammal when antibodies are transferred through the placenta & the colostrum from the mother
Non-specific defences
Defences that are always present & are the same for all organisms e.g. skin, blood clotting, inflammation, mucous membranes
Opsonins
Chemicals that bind to and tag foreign cells, making them easily recognisable to phagocytes
Passive immunity
Resistance in an organism acquired via the transfer of antibodies, provides short-term immunity as no memory cells are produced
Pathogen
Disease-causing microorganism, includes bacteria, viruses, fungi & protoctista
Penicillin
First conventional, effective & safe antibiotic derived from mould Penicillium chrysogenum, discovered by Alexander Flemming
Personalised medicine
Form of medical care that enables doctors to provide healthcare that is customised to an individual’s genotype
Phagocytes
Specialised white blood cells that engulf & destroy pathogens, 2 types: neutrophils & macrophages
Phagocytois
Process by which phagocytes engulf & destroy pathogens
Phagolysosome
Vesicle within a phagocyte formed by fusion of phagosome & lysosome
Phagosome
Vacuole inside a phagocyte, which a foreign particle is engulfed
Plasma cells
B lymphocytes that produce antibodies specific to a particular antigen
Potato blight
Disease caused by fungi-like protoctist Phytophthora infestans whose hyphae penetrate host cells, causing collapse & decay of leaves/fruit/tubers, also known as tomato blight
Primary immune response
Response of the immune system to a pathogen when it is 1st encountered, small no. of antibodies are produced slowly
Protoctista
Group of eukaryotic, single-celled microorganisms that may cause disease, digest cells & use the cell contents to reproduce
Ring rot
Bacterial disease in tomatoes/potatoes/aubergines, result in damage to leaves/fruit/tubers, caused by Clavibacter michiganensis bacterium
Ringworm
Fungal disease that affects mammals, causing grey-white circular crust lesions on the skin
Secondary immune responses
Response of the immune system to a pathogen when it is encountered for a 2nd(3rd,4th etc) time. Immunological memory gives rapid production of large no. of antibodies
Synthetic biology
Design & construct of new biological entities, reconstruction of pre-existing natural biological systems
T helper cells
T lymphocytes with CD4 receptors on cell surface membrane, these bind to antigens on antigen-presenting cells & secrete interleukins
T killer cells
T lymphocytes that produce perforin, destroying pathogens with specific antigen
T lymphocytes
Lymphocytes that mature in thymus gland, 4 main types: T helper cells, T killer cells, T memory cells & T regulator cells
T memory cells
T lymphocytes that provide immunological memory
Tobacco Mosaic Virus (TMV)
Virus that infects many species of plant, damages leaves/flowers/fruit, stunts plant growth
T regulator cells
T lymphocytes that regulate the immune response by supressing other T cells & maintaining tolerance to self-antigens
Tuberculosis (TB)
Bacterial disease caused by Mycobacterium tuberculosis & M. bovis, damages lung tissue, weakens immune system
Vaccination
Deliberate exposure of an individual to antigens from pathogen to provide artificial active immunity
Vector
Living/non-living agent that transmits a pathogen between organisms
Viruses
Non-living infectious agents that invade host cells & take over cell metabolism, replicating within them.