Module 4 : Acute Venous Pathology Flashcards

1
Q

venous system characteristics

A
  • low pressure system
  • spontaneous flow
  • demonstrate changes with respiration and augmentation/compression
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2
Q

Deep Venous Thrombosis (DVT)

A
  • occur when there is an alteration of the normal hemodynamics or architecture of the venous system
  • most common reason for a vein exam
    + 50% clinically diagnosed
  • complication
    + pulmonary embolism
    + 80% originate in LE
    + 30% mortality
  • chronic venous problems = valves
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3
Q

Virchows triad

A
  • stasis
  • hyper coagulability
  • intimal injury
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4
Q

venous stasis

A
  • MOST COMMON FACTOR
  • caused by
    + immobility
    + myocardial infarction
    + congestive heart failure
    + chronic obstructive pulmonary disease
    + obesity
    + pregnancy
    + previous DVT
    + surgery
    + paraplegia
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5
Q

hypercoagulability

A
  • clotting ability of blood increased
  • caused by
    + pregnancy
    + cancer
    + estrogen intake
    + genetic blood factors (deficiency in protein C & S anticoagulants)
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6
Q

indications for lower extremity vascular US

A
  • suspicion of DVT
  • suspicion of pulmonary embolism
  • incompetent valves and mass causing symptoms
  • edema/swelling especially unilateral
  • limb pain and tenderness
  • ulceration shallow and round
  • discolouration in gaiter area
  • varicose veins
  • hypercoagulable state
  • pallor
  • cyanosis
  • positive D-dimer test (increase in fibrin strands in blood)
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7
Q

indications for upper extremity venous US

A
  • suspicion of DVT
  • history of catheter lines or drug abuse
  • head or neck swelling/edema
  • limb redness
  • suspected injury after venous puncture (IJV)
  • symptoms of PE
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8
Q

patient history for LE DVT

A
  • acute onset of leg pain
  • acute onset of swelling
  • persistent leg calf swelling
  • redness
  • warm skin
  • symptoms of PE
  • previous DVT
  • clotting issues
  • trauma
  • surgery
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9
Q

symptoms of PE

A
  • shortness of breath SOB
  • chest pain
  • hemoptysis
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10
Q

thrombus formation

A
  • starts in sole sinus and or calf veins a valve cusps
  • predominantly due to stasis
  • formation begins as aggrgations of red cells near valve cusps due to stasis and eddy currents
  • stabilized by fibrin, thrombi become adherent to endothelium and propagation occurs
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11
Q

Acute DVT

A
  • days to 1-2 weeks old
  • dilation of the veins along with lack of compressibility
  • echogenic or isoechoic material
  • total or partial obstruction
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12
Q

disease location

A
- although any venous site can develop thrombus, common origins include
   \+ gastrocnemius and solar sinus
   \+ valve sites
   \+ venous confluence 
   \+ deep venous system
   \+ superficial venous system
   \+ perforators 
* superficial - deep
  calf veins - proximal
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13
Q

sonographic findings of acute DVT

A
  • enlarged vein with isoechoic or slightly echogenic
  • vein will not coapt
  • may not adhere well to wall and appear to float or wave within the lumen
  • collateralization may occur rapidly
  • retrograde flow
  • incompetent valves reverse flow in response to valsalva or compression proximal to site of valve
  • continuous venous flow with respiratory phasicity is abnormal and suggest proximal disease
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14
Q

sub acute thrombus

A
  • 1 to 2 months old
  • changes show increasing echogenicity and decreasing venous diameter
  • some resumption of flow through recanaliztion and formation of collaterals
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15
Q

chronic thrombus

A
  • chronic thrombotic scarring months to years after the initial event
  • moderate to high echogenicity and may be isoechoic to surrounding tissue and making it difficult to assess the vein
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16
Q

sonographic findings of chronic DVT

A
  • echogenic thrombus
  • vein smaller than artery
  • presence of collaterals
  • recanalization
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17
Q

diagnostic criteria for venous duplex - normal

A
  • complete compression of vein walls with light probe pressure
  • absent intraluminal thrombus
  • color flow fills lumen completely
  • normal venous doppler spontaneity, phasicity and augmentation
  • no venous dilation
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18
Q

diagnostic criteria for venous duplex - abnormal

A
  • lack of complete vein compression
  • intraluminal echoes present
  • decrease or absence of color flow
  • abnormal venous doppler spontaneity phasicity or augmentation
  • dilated or contracted veins noted
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19
Q

thrombosis descriptions and characteristics - acute

A
  • light to medium echogenic or anechoic
  • spongy lecture on compression
  • poorly attaches or free floating
  • dilated vein
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20
Q

thrombosis descriptions and characteristics - chronic

A
  • bright heterogenous echoes
  • irregular texture
  • attached
  • same size as artery or vein is contracted
  • collateral vein may be seen
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21
Q

can veins be partially or completely incompressible in the two acute and chronic

22
Q

can DVT be both acute and chronic

A
  • yes

0 acute on top of chronic thrombosis

23
Q

can we determine age of thrombus

24
Q

calf vein DVT

A
  • solar sinus most common site of formation
  • clinical importance is uncertain
  • propagation into pop vein varies widely
  • current treatments
    + surveillance with duplex US to check propagation into larger veins
    + therapeutic anticoagulation for 6 weeks
25
iliac DVT
- difficulty in imagingiliac veins with ultrasound - indirect assessment with doppler signal - confirmation of diagnosis with venography - compare bilateral CFV waveforms to rule out iliac obstruction
26
monophonic CFV flow
- steady continues flow suggest proximal DVT or extrinsic compression
27
axiallosubclavian veins
- use of centra venous catheters is causing increase in DVT of upper extremity - patient history of mediastinal lymphoma, previous radiation therapy, trauma or surgery can predispose them to thrombus formation - spontaneous thrombosis
28
acute disease facts and perspectives
- originates at cusps of valves - disease mechanism - superficial venous thrombosis is benign and usually diagnosed clinically - deep venous thrombosis is common and potentially fatal - 90% of PE originates from lower extremity - 60% of patient with DVT for on to have chronic venous insufficiency - thrombus anywhere is life threatening - calf vein DVT may cause PE but thrombus to little to be lethal
29
acute disease treatment - medical treatment
- anticoagulation = 3-6 months on heparin or warfarin prevents clot propagation does not dissolve thrombus + STANDARD TREATMENT - thrombolytic agent = injected to dissolve thrombus - control risk factors = not lots of rest, compression socks, check hyper coagulability
30
acute disease treatment - surgical treatment
- IVC filter = patients who can't be anti coagulated - venous thrombectomy = patient with impending limb loss if thrombolytic agent does not work - bypass grafting = caval occlusion
31
endovascular treatment
- catheter directed thrombolysis ( acute DVT) - balloon venoplasty and stenting (chronic iliofemoral DVT) - mechanical thrombectomy (acute DVT)
32
venography
- contrast injected into small veins of the foot - x ray taken of entire leg to demonstrate any disease that may be present - ascending acute disease - descending valve disorders - complete thrombus seems as lack of filing with contrast in expected location - can be painful = chemical phlebitis - differentiation between chronic and acute is hard - GOLD STANDARD
33
pulmonary angiogram
- radiographic test using contrast to evaluate the lungs for PE
34
VQ scan (ventilation quotient) / lung scan
- nuke med - involves inhaling radioactive gs to demonstrate PE - indicates perfusion and ventilation of lungs - doppler stiff can be negative with positive VQ scan - VQ scan reported as high probability normal or non high
35
isotope venographer
- nuke med - requires I-125 injection to evaluate peripheral and pulmonary veins - not utilized often in case of suspected acute thrombus because takes 24 hours fro isotope to tag thrombus
36
D- dimer assay
- lab test to detect formation of acute thrombus indication probably presence of absence of DVT - results are reported as negative (<500 ug/L) or positive (>500ug/l) - d-dimer show positive in majority of patients with recent surgery trauma pregnancy and active malignancy + not ordered as primary test
37
Wells Score (DVT probability)
- estimate probability of DVT - patient suspected of having DVT given a Wells score - done by assessing the clinical history and signs the patient has giving each positive finding a point - reported as + low probability (0) + intermediate probability (1-2) + high probability (3) - low or moderate then a D-Dimer assay next step - high then patient goes directly to get ultrasound
38
wells score factors - DVT
- malignancy - limb immobalization - patient immobilization - localized tenderness - entire leg swollen - calf swelling - pitting edema - collateral superficial ceils dilated - alternative diagnosis more likely than DVt
39
PE probability
- estimate probability of pulmonary embolism patient assessed clinically and each positive criterion given a number value - low probability (<2) - intermediate (2-6) - high (>6) - low to moderate wells score = D -Dimer test next step - high wells score = VQ scan directly
40
wells score factors - PE
- signs and symptoms of DVT - pulse > 100bpm - immobilization - previous DVt or PE - hemoptysis - malignancy - PE most likely over other diagnosis
41
phlegmasia alba dolens
- white leg - decreases venous drainage due to thrombosis of extremity deep veins without collateral drainage - extensive edema obscures capillary circulation - arterial spasms - can progress to phlegmasia cerulea dolens
42
phlegmasia cerulea dolens
- massive venous occlusion due to multisegment thrombosis - obstruction of venous outflow reduces arterial inflow causing arterial vasoconstriction - venous congestion causes a blue discolouration to skin - massive thigh and calf swelling - acute onset starting with hypoxia leading to gangrene - surgical emergency
43
may-thurner syndrome
- compression of left CIV by right CIA and spine | - increase risk for DVT and can result in left CIV stenosis and left leg swelling
44
Paget-schroetter syndrome (effort thrombosis)
- most common axillosubclavian thrombosis in ambulatory healthy people - men more commonly affected - caused by anatomical variations of muscle and bone in thoraces inlet - occurs when thrombosis of axillary/subclavian vein at thoracic inlet - more common in dominant arm
45
thrombophlebitis
- diagnosed clinically - hard cord - inflammation with thrombus formation - ultrasound used to delineate extent of thrombus particularly at major confluences into the deep system - approximately 20% of superficial thrombosis has concurrent DVT - treatment is ambulation and compression therapy along with anti inflammatory drug administration
46
congestive heart failure
- bilateral lower extremity edema from increased hydrostatic pressure - leg edema and dyspnea - increased pulsatility - may have (-) d - dimer - come to rule out DVT
47
hematomas
- accumulation of blood within tissue - due to trauma, anticoagulation, therapy, vigorous exercise - hypoechous mass with ill defined borders, contained within muscle tissues
48
abcesss & cellulitis
- result of bacterial infection - access = and enclosed collection of pus - cellulitis = diffuse collection of fluid within the subcutaneous - swelling erthema, pain tenderness resemble signs of DVT - confirm that the Venous system is patent
49
bakers cyst
- dilation of bursa communicate with knee joint - degenerative joint disease and rheumatoid arthritis - as cyst enlarges they extend into muscle planes accusing pain tenderness and swelling - usually medial to knee joint - usually anechoic but may contain debris and have septation - no flow with color doppler - ruptures cysts - may dissect into calf muscles and intramuscular septums - rule out hematoma by demonstrating communication with joint space
50
tumors
- benign or malignant may be encountered with routine US - usually solid may have necrosis - may resemble other benign pathologies important to demonstrate blood flow in solid portion
51
enlarged lymph nodes (adenopathy)
- can be mistakes for thromboses vein | - may cause limb swelling compression of veins
52
popliteal aneurysm
- considered when patient present with a lump or pain behind knee - color flow seen with aneurysm providing it is patent