Module 4

Question 1

Volume of fluid in which the drug distribute itself
throughout the body at the same concentration as in
the plasma.

Answer 1

Volume of distribution

Question 2

The range between the MEC and the MTC is called the

Answer 2

Therapuetic range or therapeutic window

Question 3

Is the pH at which half the drug (weak electrolyte) is in its ionized form

Answer 3

pKa

Question 4

Henderson-Hasselbach Equation

Answer 4

log [protonated] / [unprotonated] = pKa - pH

Question 5

The time required for the drug [plasma] to fall by 50%.

Answer 5

Plasma half-life

Question 6

Accounts for the rate of drugs eliminated or disposed by all routes in relation to the drug concentration in plasma.

Answer 6

Drug clearance

Question 7

A weak basic drug will be easily absorbed in a ___________ environment

Answer 7

Alkaline

Question 8

The drug’s initial distributive /bioavailability state is called

Answer 8

Onset

Question 9

Which drug has very limited dissolution

Answer 9

Tablets

Question 10

P coefficient <1

Answer 10

Has a lower partition coefficient and highly distributed in hydrophilic compartments

Question 11

Which drug has the best dissolution

Answer 11

Small particles

Question 12

True or false. Weak acid drugs will be charged at neutral pH

Answer 12

False. It needs to be in an acidic environment to be charged.

Question 13

The ratio of non-ionized to ionized form at each pH is known by

Answer 13

Henderson-Hasselbach Equation

Question 14

Volume of distribution formula

Answer 14

Vd=Dose /Initial plasma concentration

Question 15

Bioavailability whereinn enteral and paranteral forms of the same drug can be compared

Answer 15

Absolute

Question 16

The drug has a narrow and steep AUC is considered to be a drug with

Answer 16

Narrow margin of safety

Question 17

A less affinity drug to plasma protein means they are

Answer 17

Easily unbound and has higher tissue distribution

Question 18

These are agents that can rapidly be absorbed

Answer 18

Particle size and wetting agents

Question 19

Plasma half-life formula

Answer 19

T1/2 = log of 2 (Vd)/ Cl

Question 20

Is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium.

Answer 20

Partition coefficient

Question 21

Describes the absorptive nature of the drug depends on their chemical nature, either acidic (weak acidic drugs) or alkalinic (weak basic drugs)

Answer 21

Distributive (D) coefficient

Question 22

Formula of drug clearance

Answer 22

Cl = coefficient for CLCr of drug (creaCL/pt.weight) + units of Clcr

Question 23

The AUC of the drug will also reflect the drug activity which is called

Answer 23

Duration of area

Question 24

Rate and extent of entry of the drug
substance from the administration site until
it reaches the systemic circulation (blood).

Answer 24

Absorption

Question 25

Are able to form conjugates with drugs
or hydrolyze and oxidize drugs

Answer 25

Hepatic enzymes

Question 26

The drug concentration at which is expected to give it therapeutic effect or drug benefit

Answer 26

Minimum effective concentration

Question 27

Which phase is the metabolic phase for xenobiotic drugs

Answer 27

Phase 2

Question 28

These agents increases absorption in terms of its form

Answer 28

Salt

Question 29

P coefficient of >1

Answer 29

Has higher partition coefficient and prefers to be distributed in lipid bi-layered cell membrane

Question 30

Indicates the rate and extent of the absorbed active drug that reaches the systemic circulation

Answer 30

Bioavailability

Question 31

The type of drug kinetics that depends on drug concentration and the rate of elimination is directly proportinal to the concentration of the drug

Answer 31

Linear kinetics

Question 32

Drugs that are considered as bound drugs and has high bioavailability

Answer 32

Drugs that bind with plasma protein

Question 33

What kind of drug has a P coefficient of >1

Answer 33

Lipophilic drug

Question 34

These are agents which delay dispersion of drug and promote binding during drug absorption

Answer 34

Excipients

Question 35

What kind of drug has a P coefficient <1

Answer 35

Hydrophilic drugs

Question 36

The type of drug kinetics that is independent from drug dose-plasma concentration and rate of drug elimination is unpredictable

Answer 36

Non-linear kinetics

Question 37

A weak acid will be uncharged and a weak alkaline will be charged in the stomach due to

Answer 37

The stomach mucous having an acidic environment

Question 38

The drug concentration at which beyond the upper limit can cause drug over dosaging and form toxic effect

Answer 38

Maximum tolerated concentration

Question 39

Is a gathered plasma data of a given population, when the drug has a tested value or concentration versus the reference concentration.

Answer 39

Relative availability

Question 40

Which phase is the metabolic phase primarily for renal elimination route

Answer 40

Phase 1

Question 41

Which drug has limited dissolution

Answer 41

Granules

Question 42

A weak acid drug will be easily absorbed in a ___________ environment

Answer 42

Acidic

Question 43

A wide margin of safety drug is said to have

Answer 43

A wider AUC and a longer therapuetic window