Module 3 Gynecology Flash Cards
What is the HPO axis?
The hypothalamic-pituitary-ovarian axis
Hypothalamus (GnRH)->Anterior Pituitary (LH/FSH)-> Ovaries (Estrogen/Progesterone)
What are the uterine phases in order?
Menstrual phase
Proliferative phase
Secretory/progestational phase
What are the ovarian phases in order?
Follicular phase
Ovulatory phase
Luteal phase
What is the primary hormone in the luteal phase?
Progesterone
When does the menstrual phase begin/end?
Day 0-6/7
When does the proliferative phase begin/end? What is occurring in it?
Day 7/8-14
The endometrium begins to build to prepare for a fertilized egg
When does the secretory/progestational phase begin/end? What is occurring in it?
Day 14-28/30
The endometrium continues to thicken and progesterone rises to help maintain a healthy pregnancy for a fertilized egg. If an egg is not fertilized, the progesterone drops and the cycle begins again
When does the follicular phase occur and what is happening in it?
Day 0-13
The dominant follicle is developing due to an increase in estrogen.
When does the ovulatory phase occur and what is happening in it?
Day 14
LH and FSH surge triggers the dominant follicle/ovum to release/ovulation to occur
When does the luteal phase occur and what is happening in it?
Day 15-28/30
What does progesterones role in the menstrual cycle?
It helps proliferate the uterus and maintain a healthy home for a fertilized egg
What occurs due to the progesterone withdrawal?
Shedding is induces and the cycle begins anew
When someone presents with abnormal uterine bleeding and we given them a progesterone challenge, what result do we expect?
Withdrawal bleeding when the progesterone is ended
How can a patient prevent toxic shock syndrome?
Change tampon q 4-8 hours
Use the lowest absorbency that lasts you a few hours
Don’t leave tampon in for more than 8 hours
What increases risk of toxic shock syndrome?
Risk: tampon use (although dec. in cases after the withdrawal of highly absorbent tampons and polyacrylate rayon-containing products from the market. Half of cases NOT related to menstruation.
TSS more likely if:
Used high aborbency tampons
Used tampons continuously for more days of their cycle
Kept a single tampon in place for a longer period of time
What signs and symptoms are seen with toxic shock syndrome?
Rapid (within 48 hours) onset of:
-FEVER!! >38.9 C(102.0F)
-Rash-erythroderma, diffuse, red, macular rash resembling SUNBURN (on palms and soles)
-Hypotension Systolic<90 mmhg
-Multiorgan involvement
-GU pain, VOMITING, watery DIARRHEA
-Myalgias
-Thrombocytopenia
-Neuro: HA, somnolence, confusion, irritibility, agitation, hallucinations
What bacteria are most cases of toxic shock syndrome caused by?
Staph. aureus
-Most Methicillin-susceptible Staph aureus
How is toxic shock syndrome treated?
Remove foreign body and ABX
Vancomycin, clindamycin, zosyn
What is amenorrhea?
The absence of menses for one or more cycle
When we could consider a patient to have frequent menses?
Menses more often than every 24 days
When we could consider a patient to have infrequent menses?
Less often than every 38 days
When should we suspect an outflow tract abnormality?
A patient who has gone through the tanner stages but never had a period
What are the steps your should go through for a cost effective amenorrhea work-up?
UPT-> TSH and prolactin levels-> progestin challenge test-> no bleed=FSH/LH level
How should the progestin challenge test be ordered?
10mg for 10 days. After stopping, shedding should be expected. This means the HPO axis is working
What is the Rotterdam criteria for PCOS?
Exclusion of other etiologies an 2/3 of the following
Oligo/Amenorrhea
Clinical and/or biochemical signs of hyperandrogenism (abdn. hair growth)
Polycystic ovaries and exclusion of other criteria
What result do you expect with a progestin challenge test for a patient with PCOS?
Expect bleed
If a patient has a negative progestin challenge test, how should we respond as the APRN?
Further workup and referral!
A negative progestin challenge test means the person did NOT have a withdrawal bleed. For Varney Island purposes, think something is “big bad wrong” with the HPO axis - refer.
What conditions would we expect a high FSH?
Ovarian problems-aka high functioning hypothalamus but lack of ovarian function
-premature ovarian insufficiency
-Menopause
-Turner syndrome
What conditions would we expect a low or normal FSH?
Pituitary or hypothalamus issue
-Hypothalamic amenorrhea
-PCOS
-Rare causes of gonadotropin deficiency
What are the possible abnormalities related to a patient who has a negative progestin challenge test?
Addison’s Disease
Turner Syndrome
Autoimmune thyroid disease
Cushing syndrome
Congenital adrenal hyperplasia
Asherman syndrome
Sheehan syndrome
What types of AUB cycles are related to anovulatory cycles?
Scant, light or amenorrheic cycles
What types of AUB cycles are related to ovulatory cycles?
Heavy menstrual bleeding
What are the most common cause of AUB for <18 y/o?
Often anovulatory due to
-dysregulation of the HPO axis
-Inherited coagulopathy
What are the most common cause of AUB for 19-39 y/o?
-Leiomyomas
-Polyps
-PCOS
-Hormonal contraception
What are the most common cause of AUB for 40+ y/o?
-Menopause
-Endometrial hyperplasia
-Leiomyomas
-Endometrial carcinoma**
PALM-aka structural disorders
How can you differentiate adenomyosis from other causes of AUB?
**Heavy menstrual bleeding and dysmenorrhea
PE: Enlarged uterus, tender to exam, Enlarged uterus, usually symmetric, moderate tenderness on palpation, increased menses
Presentation: Usually in older reproductive age
Cause: Caused by endometrial tissue implanted in the myometrium
PALM-aka structural disorders
How can you differentiate leiomyoma from other causes of AUB?
Enlarged uterus, usually asymptomatic, often painless, may be associated with AUB
PALM-aka structural disorders
How can you differentiate polyps from other causes of AUB?
-Post-coital bleeding!
-Painless bleeding
PALM-aka structural disorders
How can you differentiate malignancy/hyperplasia from other causes of AUB?
40 y/o+
Post/Peri-menopausal bleeding
**What bleeding disorders could impact the menstrual cycle?
Von Willebrand
Hemophilia
What does COEIN stand for?
-Coagulopathy
-Ovulatory dysfunction
-Endometrial (endometriosis, CA, infection)
-Iatrogenic (IUDs/Meds)
-Not Otherwise Classified
On what cycle day do you draw a progesterone level to check for ovulation?
cycle day 21
What is the difference between ovulatory dysfunction and ovulatory insufficiency?
Dysfunction: when you are producing to many oocytes or the ovaries are not working properly
Insufficiency: when the ovaries are not producing enough oocytes
What hormone should be checked if the ovaries are not functioning properly?
Estrogen
What is primary dysmenorrhea?
Painful menses. Primary starts from when periods begin
-dysmenorrhea in the absence of other disease
-typically recurrent, crampy, and may radiate to the back or thighs
-can be accompanied by nausea, fatigue, and general malaise
-generally starts just BEFORE the onset of menses and lasts 2-3 days
What is secondary dysmenorrhea?
Painful periods that occur later in life
caused by a disorder
ex. endometriosis or (MOST COMMON cause)
Leiomyomata
Should we be more concerned about primary or secondary dysmennorhea?
SECONDARY because it is caused by a disorder/disease
What is PMS/PMDD and when in the cycle does it occur?
PMS: symptoms only during the luteal phase of an ovulatory cycle and relieved within 4 days. (Anger, anxiety, depression, irritability, confusion, social withdrawal)
PMDD: Severe psych symptoms during the luteal phase. At least 5 symptoms present in the final week before menses that improves with the onset of menses. Key: symptoms are associated with distress
What are our options for treating PMS/PMDD
1) nonpharmacologic approaches such as diet, exercise and psychotherapy
2) SSRIs
3) hormonal agonists and antagonists
4) vitamins and botanical products.
What is the difference between PMS and PMDD?
How it is affecting their life. PMDD affects their life significantly despite treatment.
Severe symptoms and life impaction=PMDD
Describe the endometrial biopsy procedure.
Insert speculum, clean cervix, use allis or tenaculum to stabilize cx, insert sound, insert curette and take sample. Move back in forth with tip moving from fundus to os. Repeat once or twice.
What is the main risk factor for cervical cancer?
HPV
Which types of HPV are cause most cervical cancer cases?
16 and 18!
What is the Guardasil vaccine schedule?
11-14 two doses. Second dose 6-12 months after first
15-45: three doses(0, 2 and 6 months)
If your Pap comes back ASCUS or LSIL on a 21-29 year old patient. How can you respond?
Repeat in 12 months!
At what age should cotesting of Pap and HPV occur?
Age 30
How should you respond to a patient with ACUS and negative HPV?
Repeat in 3 years
How should you respond to a patient 30+ who tests positive for HPV?
COLPO!