Module 3 Flashcards
Hypocalcemia
is defined as a calcium level of less than 8.5 mg/dL
In response to hypocalcemia, secretion of parathyroid hormone (PTH)
increases, which leads to mobilization of calcium stores from the bone and an increase in the absorption of calcium in the intestines
Carpopedal spasm (Trousseau’s sign)
is a violent, painful contraction of the hands or feet. It is one of the neuromuscular signs indicating hypocalcemia and is a significant sign of tetany. It is often preceded by muscle cramps in the legs and feet. Carpal spasm consists of a flexed elbow and wrist, adducted thumb over the palm, flexed metacarpophalangeal joints, adduction of hyperextended fingers, and extended interphalangeal joints. The response is elicited by inflation of a blood pressure cuff to 20 mm Hg above the level of the systolic blood pressure. Inflation is maintained for 3 minutes to elicit the response, which is secondary to ulnar and median nerve ischemia.
Chvostek’s sign
It is an abnormal unilateral spasm of the facial muscle when the facial nerve is tapped below the zygomatic arch anterior to the earlobe. In severe hypocalcemia, spontaneous spasms may also occur in the lower extremities and feet.
Chronic hypocalcemia may cause the skin to be
coarse, dry, and scaly
Normal serum calcium values in adults range
from 9 to 11 mg/dL.
Immediate medical treatment is indicated in patients with marked hypocalcemia
(less than 6.5 mg/dL)
Gynecomastia
is the enlargement of glandular breast tissue in men, resulting in increased breast size. True gynecomastia involves enlargement of the stromal and ductal tissues; it may present unilaterally and progress to bilateral symmetrical or asymmetrical enlargement.
Gynecomastia results from an imbalance of
androgen and estrogen or an increase in prolactin
Gynecomastia associated with puberty has an age at onset
of 12 to 14 years. The duration is approximately 6 months, followed by spontaneous regression.
A referral to an endocrinologist is required for all cases in which gynecomastia when
it occurs before puberty,
if gynecomastia does not resolve within 2 years after puberty,
if it occurs in the presence of abnormal serum levels of free testosterone and luteinizing hormone (LH),
or when gynecomastia is accompanied by the abnormal presence or the absence of secondary sex characteristics, undermasculinization, or small asymmetrical testes
How to determine true gynecomastia vs pseudo
The patient is examined in a supine position while the examiner grasps breast tissue between the thumb and forefinger and gently moves the two digits toward the nipple. A firm or rubbery, mobile, disclike mound of tissue at least 2 to 4 cm in diameter arising concentrically from beneath the nipple and areolar region confirms gynecomastia. The glandular enlargement of gynecomastia is usually resistive and ropy in texture.
The most common causes of gynecomastia
are puberty (25%), idiopathic (25%), drug related (15%), cirrhosis or malnutrition (10%), and testicular failure (10%). Other causes include renal failure, thyroid disease, neoplasms (including testicular cancer), hyperprolactinemia, Klinefelter’s syndrome, and gonadotropin deficiency.
Hirsutism
is an increase in terminal hair growth on the face, chest, back, lower abdomen, pubic area, axilla, and inner thighs.
Hirsutism is caused by
increased secretion of androgens by the ovary or adrenal glands or an increased sensitivity to androgens. It is often accompanied by menstrual irregularities.
Vellus hair
is found over most of the body and is fine, soft, and unpigmented.
Terminal hairs
are characteristically dark, coarse, pigmented, and thicker compared with vellus hair. Terminal hairs are found on the scalp, eyebrows, and the axillary and pubic areas after puberty.
Most hirsuitism cases caused by
PCOS or idiopathic
Labs to check- hirsutism
Evaluation of free testosterone levels, androstenedione, total testosterone, 17-hydroxyprogesterone, urine 17-hydroxycorticosteroids, thyroid-stimulating hormone, prolactin levels, LH, follicle-stimulating hormone (FSH), and dehydroepiandrosterone sulfate (DHEA-S)
hormonal therapy for hirsutism
will stop further hair growth but won’t reverse present hair
may take 6-24 months
Eflornithine 13.9% (Vaniqa) cream
is Food and Drug Administration–approved to reduce unwanted facial hair in women and has shown evidence of reducing hair growth on the upper lip, especially when combined with laser therapy
The most common cause of increased neck size is
an enlarged thyroid gland.
Signs of neoplasm in thyroid nodules
enlargement of node over several months, multiple nodal involvements, hard immobile mass
Polydipsia is
excessive thirst