Module 2 COPD Flashcards
LAMA
Long acting controller for smooth muscle relaxation and dilation.
- Slower onset w/long duration
Is tiotropium a LAMA or SAMA?
LAMA
COPD is largely caused by smoking; according to GOLD what is the more definitive cause?
Complex mix of genes and environment
COPD symptoms
SOB
Chronic cough
Sputum
Risk factors for COPD
Host Factors, but generally:
- Tobacco
- Occupation
- In/outdoor pollution
- Genetic predisposition
- COPD increases with age
How do you test/diagnosis COPD?
Spirometers
(FEV1/FVC)
COPD is formally diagnosed via spirometers to test post-bronchodilator. FEV1/ FVC ratio.
what ratio would be consistent with COPD?
FEV1/ FVC ratio less than 0.70
Add slides on patient history
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How is Spirometry used as a tool to diagnose COPD?
aka how does it work?
Objectively measures airflow limits
What does normal vs obstructed airflow look like?
Is COPD a obstructive or restrictive disease?
obstructive
What is the difference between obstructive and restrictive lung diseases?
obstructive: make it hard to exhale air out of the lungs.
Restrictive: makes it hard to expand their lungs with air.
What are 2 pathologies that make up COPD
Chronic bronchitis and emphysema
What is dynamic compression?
Premature compression of airways.
(leading to increased airway resistance)
What could cause increased airway resistance in a COPD patient
Air trapping
Increased secretions
What direction does the equal pressure point (EPP) move in COPD?
Toward the alveoli into the non-cartilaginous airways.
Palv < Ppl
Common symptoms of COPD
Persistent cough
Increased mucous production
Dyspnea
Muscle fatigue
Hallmark sign of COPD
productive cough
Panlobular emphysema
Type of emphysema involving distention and destruction of the entire primary respiratory lobule
- usually associated with 1-antitrypsin deficiency
Centrilobular emphysema
Weakening and enlargement of respiratory bronchioles in the proximal portion of acinus.
- Associated with smoking.
What criteria would classify as Chronic bronchitis?
presence of cough and sputum production for at least 3 months in 2 consecutive years
What does emphysema cause?
- Oxidative stress
- Airway remodeling
- enzyme; enzyme inhibitor imbalance.
Symptoms to consider a diagnosis for COPD?
- dyspnea
- recurrent lower resp. tract infection
- chronic cough/sputum
- history of risk factors
GOLD diagnosis of COPD
FEV1/ FVC ratio < 0.70