Guillain Barre Syndrome Flashcards
Define Guillain-Barré Syndrome
An Autoimmune disease the causes acute peripheral nervous system disorder that results in demyelination of neurons
- Antibodies recognize Schwann cells WBC’s destroy the myelin sheath
What are symptoms/signs of Guillain-Barré Syndrome?
- Flaccid paralysis of the skeletal muscles
- Loss of muscles reflexes
- Ascending paralysis from toes up
Guillain Barre Syndrome period of occurance?
5 days - 3 weeks after an ordinary infectious disorder, surgery, or vaccination
- infection trigger is > 50% of pts
Onset of Guillain Barre Syndrome?
Typically rapid, occurring in hours to days
Flaccid weakness predominates pts w/Guillain Barre Syndrome: what are some symptoms/complications that come with/present with it?
Diagnostic criteria of Guillain Barre Syndrome?
- Progressive weakness of more than 1 limb
- Areflexia
Guillain Barre Syndrome can lead to what respiratory complications?
Due to the diaphragm being at risk of paralysis: the following would be common
- High risk of aspiration pneumonia
- high risk of choking and asphyxiation
- Resp muscle paralysis = vents required
What are respiratory symptoms that would manifest for Guillain Barre Syndrome?
Shallow breathing and reduced RR
- Apnea
- Diminished breath sounds
- Crackles
- Muscle paralysis
Cardiovascular clinical manifestations of Guillain Barre Syndrome?
Primary Tx of Guillain Barre Syndrome?
Tx should be directed at stabilization of vitals and supportive care for pts (like pain management or bronchopulmonary hygiene)
what do you examine for Tx of Guillain Barre Syndrome typically look like?
Frequent measures of VC, BP, negative inspiratory force (NIF) and ABGs
What vitals indicate impending ventilatory failure?
VC < 20ml/kg
NIF < -30cmH2O
pH <7.35
PaCO2 >45mmHg
Medical treatments for Guillain barre syndrome?
Plasmaphersis
Intravenous immunoglobulin therapy
What is Plasmapheresis?
The removal of damaged antibodies from pts blood plasma, followed by re-transfusion of plasma
What is intravenous immunoglobulin therapy?
High-dose intravenous immunoglobulin therapy is method to reduce the severity and length of Guillain barre syndrome.
- IVIG is a blood product that contains pooled immungolbouns form donors
