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NEUR1020 > module 2 > Flashcards

module 2 Flashcards

1
Q

what are the 3 major parts of the brain

A

cerebrum
cerebellum
brainstem

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2
Q

cerebrum

A

two hemispheres divided by the longitudinal fissure

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3
Q

cerebral cortex

A

the outermost surface layer of the cerebrum (grey matter)
contains the cell bodies of the brain neurons

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4
Q

frontal lobe

A

executive functions:
- reasoning, planning, problem-solving
- inhibitory control
- working memory

motor functions:
- premotor cortex - motor planning
- primary motor cortex - execution

speech production (Broca’ area)

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5
Q

parietal lobe

A

primary somatosensory cortex:
- perception of touch

sense of space and locations

spatial attention:
- directing attention and eye-movements to explore visual world

linking vision to action:
- represents spatial location of objects around us for guiding actions

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6
Q

occipital lobe

A

Posterior part of the brain, inferior to parietal lobe

primary visual cortex (V1):
- all visual perception

Higher visual area:
- different regions process shape, colour, orientation, motion

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7
Q

temporal lobe

A

primary auditory cortex:
- perception of sound

Language comprehension:
- (Wernicke’s area)

medial temporal lobe:
- limbic system
(amygdala and hippocampus)

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8
Q

limbic system medial temporal lobe

A

amygdala:
- fear and arousal
- responds to threat/danger (snakes. spiders, angry/fearful faces)
- fear

Hippocampus
- learning and memory
- forming new episodic memories
- damage causes anterograde amnesia

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9
Q

corpus callosum

A
  • neuron connections between the left and right hemispheres
  • allows brain communication between hemispheres
  • split brain patients - left and right hemispheres disconnected. The two hemispheres cannot communicate with each other
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10
Q

Phineas gage

A
  • railway worker, Phineas Gage, accident in 1848
  • iron rod, about 1. length, went through his head
  • remained conscious during and after accident
  • damaged frontal lobes
  • died 12 years later and his skull was examined
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11
Q

Broca’s area - speech production

A

in 1861, Paul Broca described a patient who was unable to speak after damage to the left frontal lobe (Broca’s area)
- speech is slow and non-fluent
- difficulty finding appropriate words (anomia)
- speech still carries meaning
- comprehension is (mostly unaffected)

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12
Q

Wernicke’s area - language comprehension

A

in 2874, Carl Wernicke suggested that lesions to the left posterior temporal lobe led to deficits in language comprehension
- unable to understand language - deficit in comprehension
- speech is fluent with normal prosody
- speech has no meaning, nonsense, speech

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13
Q

Wilder Penfield

A
  • stimulated the brain with electrical probes while the patients were conscious, during surgery for epilepsy
  • in 1951, published maps of motor and sensory cortices of the human brain
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14
Q

homunculus

A
  • primary sensory cortex and primary motor cortex
  • brain function “mapped” by electrical stimulation
  • brain stimulation leads to sensation or movement (muscle twitch)
    size of area on cortex determines sensitivity or fine motor control
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15
Q

central nervous system

A

brain and spinal cord

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16
Q

peripheral nervous system

A

somatic nervous system (voluntary, motor and sensory)

autonomic
(involuntary, heart rate, respiration, sweating, stress, arousal, “fight or flight”)

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17
Q

Autonomic nervous system’s two divisions

A

sympathetic and parasympathetic

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18
Q

sympathetic nervous system

A
  • emotional arousal, stress, fear
  • fight or flight response
  • increases heart-rate, respiration. perspiration. pupils dilate
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19
Q

parasympathetic nervous system

A
  • rest and digest
  • lowers heart-rate, respiration
  • increases stomach, intestine activity (digestion)
  • opposes the sympathetic nervous
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20
Q

brainstem

A

medulla
- autonomic nervous system functions
- controls heart rate, respiration, regulation of blood pressure, body temperature
- reflex centres for coughing, sneezing, swallowing, vomiting

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21
Q

disorders of consciousness

A
  • severe damage to upper brain (hemispheres and cortex)
  • of brainstem is not damaged, autonomic nervous system functions can remain
  • sometimes normal respiration, control of heart rate, some face and eye movement remain
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22
Q

locked in syndrome

A
  • amyotrophic lateral sclerosis (ALS) or motor neurons disease
  • loss of motor neurons to spinal or brain injury
  • intact cerebrum and brainstem, but disconnected from spinal cord
  • normal cognitive function, vision, and hearing, but patients cannot move
  • patients may be fully conscious and aware, but totally unresponsive
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23
Q

medulla

A
  • Autonomic nervous system
    • Controls heart-rate, respiration, regulation of blood pressure, body temperature
      Reflect centres for coughing, sneezing, swallowing, vomiting
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24
Q

persistent vegetative state

A
  • sever damage to upper brain
  • if brainstem is not damaged, autonomic nervous system functions can remain
  • sometimes normal respiration, control of heart rate, some fave and eye movements remain
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25
Q

cerebellum

A
  • hind brain
  • sense of balance and co-ordination
  • motor learning
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26
Q

dendrite

A
  • unique to neurons
  • received signals
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27
Q

axon

A
  • sends signals
  • wrapped in myelin for efficient transmission of signals along the axon
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28
Q

axon terminals

A
  • form synapses with other neurons
  • secrete neurotransmitters to send signals across synapses to other neurons
29
Q

glial cells

A

supporting cells for neurons

30
Q

three types of glial cells

A

oligodendrocytes, astrocytes and microglia

31
Q

oliogodendrocrytes

A

produce the myelin sheath that wraps around axons

32
Q

astrocytes

A

supply nutrients from blood to the neurons.
main blood-brain barrier

33
Q

microgolia

A

brain’s immune system. clean up foreign or toxic substances

34
Q

the myelin of axons

A

oligodendrocytes form myelin sheath by wrapping around the axon. essential for efficient communication, for propagation of signals along axon.

35
Q

multiple sclerosis

A

involves loss of myelin, disruption of efficient neural communication throughout the body

36
Q

synapses

A

join axon terminals of one neuron for transmission of signals between neurons

37
Q

pre-synaptic

A

before the synapse. from cell body to axon terminal

38
Q

post synaptic

A

after the synapse. from dendrite to cell body

39
Q

sodium and potassium are…

A

positively charged ions

40
Q

membrane potential

A

difference in the electrical charge (voltage) between inside and outside cell, across cell membrane wall

41
Q

resting potential

A

at rest. more positive ions outside than inside the cell gives overall negative potential inside compared with outside the cell

42
Q

what is the different in electrical charge at rest

A

-70mV

43
Q

ion channels

A

in cell membrane wall open and close to pass or block movement of ions across cell membrane

44
Q

three types of ion channels

A

sodium potassium pump
voltage dependent ion channels
ligand-gated ion channels

45
Q

ion channel 1: sodium potassium pump

A
  • Actively pumps Na+ and K+ across cell membrane
    • Overall pumps positive charge out of cell (3 Na+ out for every 2 K+ in)
      Use energy - about 25% of body total energy, 70% of brain energy!
46
Q

action potential

A

Transmission of electrical signal along axon

47
Q

depolarisation of cell:

A

membrane potential goes back to 0

48
Q

repolorisation

A

membrane potential back to -70mV resting potential

49
Q

ion channel 2

A

voltage-dependent ion channels
- Voltage-depended ion channel, closed at resting potential
- Open when membrane potential reaches threshold voltage
- Allows flow of ions across cell membrane

50
Q

synapses

A

join axon terminals of one neuron to dendrites of another neuron for transmission of signals

51
Q

re-takeup pump

A

clears neurotransmitter from synaptic cleft back into pre-synaptic terminal

52
Q

enzymes

A

break down neurotransmitter in synaptic cleft

53
Q

parkinsons disease

A

loss of dopamine in the basal ganglia deep in the brain

54
Q

reflex

A

Sensory neuron (input) passes signal to motor neuron (output) to cause muscle contraction.

55
Q

Sending signals: neurotransmitter release

A
  • Depolarisation of axon terminal (action potential) triggers release of neurotransmitter
    • Neurotransmitter acts on receptor on post-synaptic neuron to open ion channels and pass signal
56
Q

ligand gated ion channels

A
  • Neurotransmitter receptors open ion channels when neurotransmitter binds
    • Different neurotransmitters bind to and open different ion channels (Na+, K+, CI-) to change membrane potential in different ways
57
Q

receptor binding

A
  • Can cause depolarisation (less negative) e.g. Na+ flow in
    Can cause hyperpolarisation (more negative) e.g. K+ flows out or CI= flows in
58
Q

excitatory

A
  • Receptor opens channels that cause depolarisation
    • ESPS: excitatory post-synaptic potential
      Closer to threshold for action potential
59
Q

inhibitory

A
  • Receptor opens channels that cause hyperpolarisation
    • IPSP: inhibitory post-synaptic potential
    • Further from threshold for action potential
60
Q

graded potentials

A
  • Excitatory and inhibitory inputs (via dendrites) combine together
    • Change membrane potential on postsynaptic cell
    • Graded potential on postsynaptic cell depends on strength of synapse connection (on dendrite)
61
Q

neural integration

A

Determines whether sensory neuron (input) passes signal to motor neuron (output) to cause muscle contraction

62
Q

eeg, erp, mri and fmri

A

EEG: electroencephalography
ERPs: event-related potentials
MRI: magnetic resonance imaging
fMRI: functional magnetic resonance imaging

63
Q

Single neuron recording

A
  • Place a thin electrode into an animal’s brain (rat, cat, monkey)
    • Record action potentials “firing” from a single neuron
      Measure what that neuron encodes or detects
64
Q

EEG-electroencephalography

A
  • Summed activity from action potentials of neurons in the cortex cause electrical activity change on the scalp (skin of the head)
    Measure voltage changes from electrodes placed in the scalp
    used for detecting sleep and seizures
65
Q

erp

A

detecting deafness of baby
ERPs can show precise time of information processing in the brain
- 100ms viewing any stimuli
- Peak of brain activity 100ms after seeing visual stimulus
170ms viewing face

66
Q

Problems of ERP

A
  • Difficult to accurately localise activity to specific brain areas
    • Poor spatial resolution
    • Measures electrical potential conducted across the scalp
      Hard to determine exactly where in the brain this activity comes from
67
Q

fMRI

A
  • Measures change in blood oxygen level
    • Active neurons use oxygen
      change in blood oxygen levels = change in brain activity
68
Q

problems with fMRI

A
  • Indirect measure of brain activity
    • BOLD signal from change in blood oxygen level
    • Not precise timing of neural activity
    • Very expensive
69
Q
A

NEUR1020 (4 decks)

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