Module 2 Flashcards
How is it possible for SA node fibers to generate their own action potentials?
a.) they release their own excitatory neurotransmitters
b.) voltage gated sodium channels open when the fiber is at its resting membrane potential
c.) the opening of ligand gated sodium channels
d.) epinephrine opens calcium channels
b.) voltage gated sodium channels open when the fiber is at its resting membrane potential
What allows for the action potentials to spread between cardiac muscle fibers?
a.) voltage gated sodium channels
b.) desmosomes
c.) voltage gated calcium channels
d.) gap junctions
d.) gap junctions
What is one way that cardiac and skeletal muscle fibers differ in terms of the process of contraction?
a.) calcium for contraction comes mostly from the SR in cardiac muscle fibers
b.) there is no DHP receptor in the T-tubule in cardiac muscle fibers
c.) calcium for contraction comes mostly from the extracellular fluid in cardiac muscle fibers
d.) DHP and ryanodine receptors are physically attached in cardiac muscle fibers
c.) calcium for contraction comes mostly from the extracellular fluid in cardiac muscle fibers
What pathway is activated when adrenergic receptors on the SA node fibers are stimulated?
a.) calcium calmodulin
b.) PIP2
c.) IP3
d.) cAMP
d.) cAMP
How does the activation of the cAMP pathway result in an increase in heart rate?
a.) by opening sodium and calcium channels
b.) by closing potassium channels
c.) by closing sodium and calcium channels
d.) by opening potassium channels
a.) by opening sodium and calcium channels
How does stimulation of adrenergic receptors on ventricular cardiac muscle fibers result in them producing more force?
a.) by opening sodium channels
b.) by increasing the amount of intracellular calcium
c.) by decreasing the calcium ATPase rate on the SR
d.) by opening potassium channels
b.) by increasing the amount of intracellular calcium
Regarding RER, if someone is consuming much more oxygen than carbon dioxide is being produced, what macronutrient are their muscle cells mostly consuming for the production of ATP?
a.) carbs
b.) protein
c.) fatty acids
c.) fatty acids
At lower exercise intensities, RER is typically closer to .7. Which statement is accurate based on this fact?
a.) most intermediate fast twitch muscle fibers are active, which mostly rely on a combination of aerobic and anaerobic metabolism.
b.) all muscle fiber types are likely active
c.) mostly fast twitch muscle fibers are active, which rely on anaerobic metabolism.
d.) most slow twitch muscle fibers are active, which mostly rely on aerobic metabolism.
d.) most slow twitch muscle fibers are active, which mostly rely on aerobic metabolism.
As exercise intensity increases, RER will get closer to 1. What is mostly contributing to this shift in RER?
a.) fast twitch muscle fibers are being recruited, which rely more heavily on aerobic and anaerobic glycolysis.
b.) fast twitch muscle fibers have been recruited, which means the body completely stops using fat as an energy source.
c.) mostly slow twitch muscle fibers are active, which mostly rely on aerobic metabolism.
d.) type IIa muscle fibers have been recruited, which rely almost exclusively on anaerobic metabolism.
a.) fast twitch muscle fibers are being recruited, which rely more heavily on aerobic and anaerobic glycolysis.
During prolonged steady state low intensity exercise, fatty acids progressively get more utilized by the working muscle cells. What is one factor that accounts for this shift?
a.) rising blood levels of lactate
b.) rising blood levels of hydrogen ions.
c.) fast twitch fibers are initially recruited, but are then “shut off”
d.) rising body temperature and blood levels of epinephrine
d.) rising body temperature and blood levels of epinephrine
One theory regarding fatigue during long duration endurance events is that glycogen becomes depleted within the muscle cells, making the cells almost entirely reliant on fatty acids. What is one of the reasons that this may cause fatigue?
a.) ketones are produced, which are acidic
b.) higher quantities of hydrogen ions will be produced.
c.) there is a lack of fatty acids in the blood to sufficiently meet ATP demand
d.) pyruvate is needed to make Krebs cycle intermediates, that are used to break down fatty acids at a sufficient rate to meet ATP demand
d.) pyruvate is needed to make Krebs cycle intermediates, that are used to break down fatty acids at a sufficient rate to meet ATP demand
With regard to the length-tension relationship, at what elbow joint angle should the sarcomeres within biceps muscle fibers produce the most force?
a.) 30 degrees
b.) 90 degrees
c.) 0 degrees
d.) 145 degrees
b.) 90 degrees
Why does shortening velocity within a fiber increase as force decreases?
a.) less myosin can be bound to actin at a given time
b.) the sarcomere is moved into a suboptimal position
c.) the cycling rate of myosin decreases
d.) increased velocities decrease how much calcium can bind to actin
a.) less myosin can be bound to actin at a given time
What is one possible explanation why type IIx fibers can produce more force at a given velocity than type IIa fibers?
a.) they are less fatigue resistant
b.) they use anaerobic metabolism to a greater degree
c.) they have a higher myosin cycling rate
d.) they have much greater specific force/tension
c.) they have a higher myosin cycling rate
What type of muscle fiber is most resistant to fatigue?
a.) Type I
b.) Type IIx
c.) Type IIa
a.) Type I
Which type of muscle fiber has the highest myosin ATPase rate?
a.) Type I
b.) Type IIx
c.) Type IIa
b.) Type IIx
What does a high myosin ATPase rate tell you about Type IIx fibers?
a.) it takes a lot of time to produce peak force.
b.) they resist fatigue well.
c.) they have a great ability to oxidize fatty acids
d.) they shorten fast
d.) they shorten fast
During very low intensity endurance exercise, what would you expect to happen?
a.) primary motor cortex neurons would fire frequently enough to activate small, medium and large sized alpha motor neurons
b.) there would not be activation of any motor neurons at this intensity
c.) primary motor cortex neurons would only fire frequently enough to activate small alpha motor neurons
d.) primary motor cortex neurons would fire frequently enough to activate small and medium sized alpha motor neurons
c.) primary motor cortex neurons would only fire frequently enough to activate small alpha motor neurons
Why would the primary motor cortex neuron only fire frequently enough to activate small alpha motor neurons during very low intensity exercise?
a.) we need activation of all types of muscle fibers.
b.) we only need activation of type I and type IIa muscle fibers
c.) we only need activation of type I muscle fibers
d.) we only need activation of type IIa muscle fibers
c.) we only need activation of type I muscle fibers
Why is there a steady but not significant rise in lactate from 20-60% of VO2max (lower intensity exercise)?
a.) cells are always producing some lactate, this is just chance
b.) type IIa fibers have been recruited and are producing some lactate, but not enough of serious significance
c.) type I fibers are being pushed towards their upper limit and are relying more on anaerobic glycolysis
d.) type IIa fibers have been recruited, which always produce lactate
b.) type IIa fibers have been recruited and are producing some lactate, but not enough of serious significance
At what exercise stage is lactate threshold hit?
a.) 2
b.) 3
c.) 4
d.) 5
b.) 3
What is the likely explanation for what causes lactate threshold?
a.) type IIx fibers have been recruited, which produce ATP mostly through anaerobic glycolysis
b.) type IIa fibers have become very reliant on anaerobic metabolism at this point and type IIx fibers have also been recruited (which rely almost exclusively on anaerobic glycolysis)
c.) type IIa fibers have just began to produce lactate at this intensity
d.) type IIx fibers have reached an intensity at lactate threshold where they transition from aerobic to anaerobic glycolysis
b.) type IIa fibers have become very reliant on anaerobic metabolism at this point and type IIx fibers have also been recruited (which rely almost exclusively on anaerobic glycolysis)
Why does fatigue typically occur around lactate threshold?
a.) type IIx fibers are now involved and fatigue always occurs once they are activated
b.) the accumulation of lactate in the fibers is causing fatigue
c.) this is the point where the ATP demand is likely rising above supply in type IIa as well as type IIx fibers
d.) the accumulation of lactate in the blood is making the body acidic
c.) this is the point where the ATP demand is likely rising above supply in type IIa as well as type IIx fibers
How does training right around lactate threshold influence the active fibers?
a.) they will get better at buffering lactate
b.) type I muscle fibers will be adapt to using glycolysis
c.) they will get better at making ATP through anaerobic glycolysis
d.) they will become better at meeting ATP demand by improving their ability to run aerobic metabolism
d.) they will become better at meeting ATP demand by improving their ability to run aerobic metabolism
What is the equation for cardiac output?
a.) HR x a-VO2 difference
b.) SV x a-VO2 difference
c.) HR x SV
d.) aortic pressure x TPR
c.) HR x SV
Cardiac output continues to rise as exercise intensity rises, despite a plateau in SV. What is the explanation for this plateau?
a.) excessive heat
b.) decreased filling time with higher heart rates
c.) loss of blood plasma
d.) diminished sympathetic activation
b.) decreased filling time with higher heart rates
Why might a plateau be observed in SV and not a decrease in an untrained individual?
a.) decrease in aortic pressure
b.) increased sympathetic stimulation of cardiac muscle fibers
c.) increased venous return to due respiratory and muscle pump
d.) increase in HR
b.) increased sympathetic stimulation of cardiac muscle fibers
How is it possible for cardiac output to continue to rise with higher intensity exercise despite the plateau in SV?
a.) decrease in aortic pressure
b.) increased sympathetic stimulation of cardiac muscle fibers
c.) increased venous return to due respiratory and muscle pump
d.) increase in HR
d.) increase in HR
Why does SV continue to rise with higher intensity exercise in very well trained athletes?
a.) they have a better ability to return blood to the heart through the respiratory and muscle pump
b.) they have greater stimulation of the sympathetic nervous system
c.) they have increased ability to regulate aortic pressure
d.) TPR drops to a greater degree
a.) they have a better ability to return blood to the heart through the respiratory and muscle pump
What does a-VO2 difference look at?
a.) total peripheral resistance during exercise
b.) the amount of CO2 produced divided by the amount of O2 consumed
c.) the difference in arterial and venous blood oxygen content
d.) HR x SV
c.) the difference in arterial and venous blood oxygen content
What is the most likely explanation for why cardiovascular drift must occur?
a.) increased parasympathetic activation
b.) increased sympathetic activation
c.) decreased filling time with higher heart rates
d.) loss of blood plasma decreases stroke volume
d.) loss of blood plasma decreases stroke volume
What will the release of metabolites like CO2, ADP, H+, etc. from working muscles result in with regard to the cardiovascular system?
a.) contraction of smooth muscle within blood vessels around the working muscles
b.) relaxation of smooth muscle within blood vessels around the working muscles
c.) decreased blood flow
d.) an increased mean arterial pressure and consequently increased afterload
b.) relaxation of smooth muscle within blood vessels around the working muscles