Module 1.3: Review: Cellular Transport System Flashcards

1
Q

The ___ separates the components of a cell
from its environment and is what surrounds the cell.

A

cell membrane

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2
Q

The cell membrane is also referred to as the “gatekeeper” of the cell because ___.

A

it regulates the flow of materials into and out of cell, as it is selectively permeable

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3
Q

___ is defined as the stable internal balance.

A

homeostasis

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4
Q

What part of a cell is responsible for maintaining homeostasis within the cell?

A

cell membrane

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5
Q

The cell membrane maintains homeostasis through balancing the ___. (4)

A
  1. pH
  2. temperature
  3. glucose (sugar intake)
  4. water balance
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6
Q

True or False

The cell membrane maintains homeostasis within a cell only through active transport.

A

False

The cell membrane maintains homeostasis within a cell through active and passive transport.

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7
Q

The ___ of a solution tells how acidic or basic it is.

A

pH

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8
Q

What solutions are considered acidic, neutral, and basic?

A

acidic = solutions from 0-6 pH
basic = solutions from 8-14 pH
neutral = solutions with a 7 pH

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9
Q

All cells have a cell membrane made of ___ ____, and ____. (3)

A
  1. phosphate
  2. proteins
  3. lipids

Hence, it is called the phospholipid bilayer.

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10
Q

True or False

The cell membrane both repels and attracts water through the membrane at the same.

A

True

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11
Q

A single phospholipid has ___ heads and ____ fatty acid tails.

A

hydrophilic (water-loving) phosphate;
hydrophobic (water-hating)

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12
Q

__ is a process that does not require energy to move molecules from a high to a low concentration.

A

passive transport

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13
Q

What are three (3) types of passive transport?

A
  1. diffusion or simple diffusion
  2. facilitated diffusion
  3. osmosis
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14
Q

___ is the movement of small particles across the cell membrane until homeostasis is reached.

A

diffusion

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15
Q

____ requires the help of carrier and channel proteins.

A

facilitated diffusion

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16
Q

During diffusion, particles move from an area of ___ concentration to an area of ___ concentration.

A

high;
low

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17
Q

____ is the movement of water through a selectively permeable membrane. This is in which water moves across the cell membrane from an area of high concentration to an area of low concentration.

A

osmosis

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18
Q

What are the three (3) types of solutions in osmosis?

A
  1. isotonic
  2. hypotonic
  3. hypertonic
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19
Q

____ solutions contain the same concentration of solute as another solution.

A

isotonic

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20
Q

When a cell is placed in an isotonic solution, the water ____ at the _____ rate.

A

diffuses into and out of the cell;
same

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21
Q

___ solutions contain a low concentration of solute relative to another solution (e.g. cell cytoplasm).

A

hypotonic

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22
Q

When a cell is placed in a hypotonic solution, the water diffuses ___ the
cell, causing the cell to ___ and ____.

A

into;
swell and possibly explode

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23
Q

___ solutions contain a high concentration of solute relative to another solution (e.g. cell cytoplasm).

A

hypertonic

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24
Q

When a cell is placed in a hypertonic solution, the water diffuses ___ of the cell, causing the cell to ____.

A

out;
shrivel

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25
Q

In a hypertonic solution, the water or solution outside the cell is ___ than the inside of the cell.

This will cause the cell to ___ and ___.

A

saltier;
shrivel and shrink

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26
Q

A hypotonic solution will cause the cell to take in water and ____.

A

swell

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27
Q

True or False

The water outside of the cell in an isotonic solution has an UNEQUAL amount of salt as the water inside the cell.

A

False

EQUAL

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28
Q

What are the four (4) types of active transport?

A
  1. EXOcytosis
  2. ENDOcytosis
  3. PINOcytosis
  4. PHAGOcytosis
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29
Q

____, an active transport, refers to how materials EXIT the cell (or how the cell uses the bathroom).

A

EXOcytosis

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30
Q

____, an active transport, refers to how materials ENTER the cell (cell eating or engulfing).

A

ENDOcytosis

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31
Q

___, an active transport, refers to how SMALL materials enter the cell (cell eating/engulfing).

A

PINOcytosis

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32
Q

____, an active transport, refers to how LARGER materials enter the cell (cell eating/engulfing).

A

PHAGOcytosis

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33
Q

___ is a process that requires energy, the movement of molecules from low to high concentration.

A

active transport

34
Q

In active transport, why is energy required?

A

Energy is required as molecules must be pumped against the concentration gradient.

35
Q

What is one example of an active transport?

A

CO2 pumped out by body cells into the surrounding blood vessels to be carried to the lungs for exhale.

36
Q

Why does active transport need energy but passive transport does not?

A

Active transport needs energy because it moves molecules against their concentration gradient, from an area of low concentration to an area of high concentration.
Passive transport does not need energy because it moves molecules along their concentration gradient, from an area of high concentration to an area of low concentration.

37
Q

____ refers to the distribution of charge across the cell membrane.

A

membrane potential

38
Q

Membrane potentials develop because of
____ between the inside and outside of the cell.

A

differing ion concentrations

39
Q

____ is the difference in electric potential between two points.

A

potential difference or voltage (V)

40
Q

What are the principles of electricity? (4)

A
  1. voltage (V) - the difference in electrical potential between two points.
  2. current - the flow of electric charge, in amperes (A).
  3. resistance - the opposition to the flow of electric charge, ohms (Ω).
  4. capacitance - the ability to store electrical charge, in farads (F).
41
Q

What are some principles of current? (3)

A
  1. like charges repel, unlike attract.
  2. ions tend to move from areas of GREATER concentration to areas of LOWER concentration.
  3. the movement of a positive ion from one side of a membrane to the other implies a negative charge is left behind.
42
Q

According to ____, the voltage across a conductor is directly proportional to the current flowing through it, provided all physical conditions and temperature, remain constant.

A

Ohm’s law

43
Q

What is the formula of current flow?

A

I = E/R

I = current flow
E = electrical potential
R = resistance

44
Q

____ membrane potential describes the steady state of the cell.

A

resting

45
Q

What are some of the principles of resting membrane potentials?

A
  1. by convention - ECF (outside of the cell) is assigned a voltage of zero.
  2. the polarity of the membrane is stated in terms of the sign of the excess charge inside of the cell.
46
Q

What are the two (2) types of membrane ion channels?

A
  1. leak channels
  2. Na+K+ATPase pump
47
Q

____ refers to a type of membrane ion channel that is open all of the time, the slow leak of ions. It is the simplest type of ion channel in that their permeability is more or less constant (neurons).

A

leak channels

48
Q

True or False

Leak channels open and close at RANDOM, allowing ions to pass through when they are open.

A

True

49
Q

___ is an enzyme that actively transports sodium (Na+) ions out of the cell and potassium (K+) ions into the cell. It is essential for maintaining the resting membrane potential and for regulating nerve signaling.

A

Na+K+ATPase pump

50
Q

What are the complications of high potassium?

A

also referred to as hyperkalemia, some of its complications are:

  1. muscle weakness/paralysis
  2. arrhythmia (irregular heartbeat)
  3. heart attack
  4. cardiac arrest
51
Q

What are the two (2) forms of ion gradients?

A
  1. chemical concentration gradient
  2. electrical concentration gradient
52
Q

Together, the two forms of ion gradients are then known as the ____.

A

electrochemical agent

53
Q

A cell with a resting membrane potential is said to be ____ (polarized or nonpolarized).

A

polarized

54
Q

What are some of the factors that determine the resting membrane potential? (4)

A
  1. selective permeability of the of the plasma membrane
  2. leak channels
  3. Na+K+ATPase pump
  4. differences in ion concentrations
55
Q

What is the formula of equilibrium potential (Nernst potential)?

A

E(x) = RT/ZF log [x] inside/[x}]

E(x) = gas constant
T = temperature degrees (K)
Z = charge on ion/s (valence)
F = Faraday’s constant

56
Q

An ____ is a globular protein that functions as a biological catalyst, speeding up a reaction rate.

A

enzyme

57
Q

How do enzymes speed up a reaction rate?

A

they lower the activation energy by the reaction it catalyze.

58
Q

Enzymes of the digestive tract and those found in blood are present in an inactive form called ____.

A

zymogen or proenzymes

59
Q

An ___ is a region on the surface of an enzyme to which substrates will bind and catalyze a chemical reaction.

A

active site

60
Q

True or False

Enzymes are highly SPECIFIC for the type of reaction they catalyze and for their susbtrate.

A

True

61
Q

What are the types of specificity recognized by enzymes? (4)

A
  1. absolute specificity
  2. group specificity
  3. reaction specificity
  4. stereospecificity
62
Q

Conjugated proteins, also referred to as ____.

A

holoenzyme

63
Q

An enzyme without a non-protein part is known as ____.

A

apoenzyme

64
Q

The polymerization of deoxyribonucleotides into a DNA strand is catalyzed by the ____, a holoenzyme.

A

DNA polymerase

65
Q

The catalytic activity of DNA polymerase is catalyzed by the _____.

A

magnesium ion

66
Q

According to the IUBMB system of enzyme nomenclature, enzymes are grouped into 6 major classes: (6)

A

EC 1 OXIDOREDUCTASES
EC 2 TRANSFERASES
EC 3 HYDROLASES
EC 4 LYASES
EC 5 ISOMERASES
EC 6 LIGASES

67
Q

What are some factors that affect the reaction velocity? (8)

A
  1. temperature
    1.2 hydrogen ion concentration (pH)
    1.3 substrate concentration
    1.4 enzyme concentration
    1.5 products of the reaction
    1.6 presence of an activator/inhibitor
    allosteric effect
    1.7 time
68
Q

The study of reaction rate and how they
change in response to changes in the experimental parameter is known as ____.

A

kinetics

69
Q

The mathematical equation that defines the quantitative relationship between the rate of anenzyme reaction and the substrate concentration is the ____.

A

Michaelis-Menten equation

70
Q

What is the equation of Michaelis-Menten?

A

V₀ = Vmax [S] / Km + [S]

V₀ = observed velocity at the given [S]
Km = Michaelis-Menten constant
Km = (K-1 + K2) / K1
Vmax = maximum velocity at saturating [S]
conc.

71
Q

According to the ____ plot, a linear representation is more accurate and convenient for determining Vmax and
Km.

A

Lineweaver-Burk

72
Q

The ____ equation is obtained by taking the reciprocal of both sides of the Michaelis-Menten equation.

A

Lineweaver-Burk

73
Q

____ is the process of reducing the activity of an enzyme. It involves any substance that can diminish the velocity of an enzyme catalyzed.

A

enzyme inhibition

74
Q

True or False

Enzyme inhibitors include drugs, antibiotics, poisons, and anti-metabolites.

A

True

75
Q

True or False

Enzyme inhibition forms the basis of drug designing.

A

True

76
Q

What are the types of enzyme inhibitors? (2)

A
  1. reversible
  2. irreversible
77
Q

Reversible inhibitors can be classified into: (3)

A
  1. competitive
  2. non-competitive
  3. un-competitive
78
Q

____ inhibitors are molecules that bind to the active site of an enzyme, preventing the substrate from binding.

A

competitive

79
Q

____ inhibitors bind to an allosteric site on the enzyme, which is a different site from the active site. Its binding changes the shape of the enzyme, making it less active.

A

noncompetitive

80
Q

____ inhibitors only bind to the enzyme-substrate complex, which means that they cannot bind to the enzyme alone.

A

uncompetitive

81
Q

True or False

The rate of the reaction or velocity is directly proportional to the enzyme concentration when sufficient substrate is ABSENT.

A

False

PRESENT

82
Q

The ____ in a reaction causes the inhibition of enzyme activity.

A

accumulation of a product