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Epidemiology > Module 12 > Flashcards

Module 12 Flashcards

1
Q

What are two major sources of error in epidemiologic research?

A

Random (or chance) errors (reliability)
Systemic errors- all occurring for a specific reason (validity, bias)

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2
Q

What can cause a lack of precision?

A

Sampling error, imprecision in measurement, and variability of the data

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3
Q

What is the result of lack of precision?

A

Wider confidence interval
Makes it more difficult to reject the null hypothesis

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4
Q

How can you reduce random error d/t lack of precision?

A

Increase the sample size and/or increase the number of measurements and taking the average of those measurements

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5
Q

What can systematic errors be caused by?

A

Selection bias, information bias, or confounding

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6
Q

What occurs as a result of systemic error?

A

Changes the value of results (odds ratio or relative risk) by moving it up or down

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7
Q

How to reduce systemic bias

A

Prevent it when designing or carrying out the study or adjusting for confounding in the analysis

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8
Q

What are the two components of validity?

A

Internal validity
External validity

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9
Q

Characteristics of lack of internal validity

A

It’s the same as bias in a study.
It is systematic error.
It is affected by how the study was designed and carried out

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10
Q

A study is said to have high internal validity when…

A

There have been proper selection of study groups-little selection bias
A lack of systematic error in measurement- little information bias,
And the results are not due to confounding

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11
Q

High internal validity = ?

A

Low bias

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12
Q

Definition of systematic errors?

A

Errors in how samples were selected or the quality of the data used

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13
Q

What does external validity imply?

A

The ability to generalize beyond a set of observations to some universal statement

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14
Q

What is external validity affected by?

A

The source population from which the sample is drawn and by the level of internal validity in the study

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15
Q

Question asked for internal validity

A

Could the association be d/t bias (internal validity issues?) Selection bias and/or information bias

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16
Q

Question regarding external validity

A

To whom does this association apply? To what extent may the findings from the study be generalized to other pops?

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17
Q

Which is more important: internal or external validity?

A

A study can have good internal validity (not much bias) but still not be externally very valid (limited generalizability to a source pop)
However, a study cannot be externally valid without being internally valid
In other words, if a study has a great deal of bias, you cannot accurately generalize to a universal statement, or to any population

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18
Q

Definition of bias

A

Deviation of results or interferences from the truth, or processes leading to such deviation. Any trend in the collection, analysis, interpretation, publication, or review of data that can lead to conclusions that are systematically different from the truth.

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19
Q

When does overestimation of association occur?

A

If the two comparison groups are more different in the study than they are in reality

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20
Q

Overestimation of association in case-control studies

A

The odds of exposure to a risk factor is overestimated in the cases
The odds of exposure to a risk factor is underestimated in the controls

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21
Q

Overestimation of association in cohort studies

A

The incidence of the outcome in the exposed is overestimated
The incidence of the outcome in the unexposed is underestimated

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22
Q

When does underestimation of the association occur?

A

If the two comparison groups are less different in the study than they are in reality

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23
Q

Underestimation of the association in case-control studies

A

The odds of exposure to a risk factor is underestimated in the cases and overestimated in the controls

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24
Q

Underestimation of the association in cohort studies

A

The incidence of the outcome in the exposed is underestimated and overestimated in the unexposed

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25
Q

How bias occurs in descriptive studies

A

The prevalence (not just the prevalence ratio) in descriptive cross-sectional studies can be biased up or down
This can be caused by selection bias of some sort (improperly selected sample) or information bias (data obtained from sample not correct)

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26
Q

Definition of selection bias

A

A bias d/t differences in the manner in which study groups are formed: bias in how people are selected into the sample

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27
Q

When does a selection bias occur?

A

Arises when the relationship between exposure and dz is different for those who participate and those who theoretically would be eligible for the study but do not participate

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28
Q

Selection bias is not the same as…

A

Random sampling error

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29
Q

Why is selection bias not the same as random sampling error?

A

They are both sampling problems, but for different reasons
Sampling error is due to low sample size
But selection bias is d/t recruitment of the wrong ppl. It cannot be corrected by increasing the sample size

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30
Q

Types of selection bias

A

Non-response bias
LTFU bias
Healthy worker effect
Exclusion bias
Incidence-prevalence bias
Hospital admission bias

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31
Q

When does non-response bias occur?

A

When the response rate is low and non-respondents are systematically different than respondents

32
Q

Definition of response rate

A

The proportion of potential participants who are asked to participate in the study and actually did participate divided by the total who were asked to take part in the study (both those who accepted and those who refused)

33
Q

When can volunteer bias occur?

A

When people volunteer for a study, as volunteers are often systematically different than the general pop. This occurs when sample participants have been self-selected

34
Q

Which type of sample involves some degree of volunteer bias?

A

Convenience (nonprobability) survey samples

35
Q

When does LTFU bias occur?

A

When ppl drop out of a study, and those who drop out are systematically different than those who remained

36
Q

In what two situations does healthy worker effect occur?

A
  1. When an occupational group is compared to the general pop, which includes ppl too unhealthy to work.
  2. When “sicker ppl choose to work in environments where exposures are low, are excluded from being hired, or once hired, are transferred to less exposed jobs or leave work”
37
Q

What does healthy worker effect lead to?

A

Underestimate of the association

38
Q

When can exclusion bias occur?

A

If the exclusion criteria for participants are different for the comparison groups in the study

39
Q

When does hospital admission bias occur?

A

When hospitalized participants are used as a “healthy” comparison group, but actually are not representative of people without the dz being studied. This can happen if hospitalization rates differ for the exposed and not exposed. The association between exposure and dz in the hospitalized sample may not reflect what it is in non-hospitalized ppl

40
Q

Why can incidence-prevalence bias occur?

A

Because prevalence is influenced by the duration of the dz and whatever is influencing that- not just what causes one to get the dz in the first place. Including participants who are prevalent cases can introduce bias, since what led to their survival (and hence inclusion in the study) may be something different than what caused them to get the dz

41
Q

Common forms of selection bias in cross-sectional studies

A

Non-response bias
Volunteer bias
Incidence-prevalence bias

42
Q

Common types of selection bias in case-control studies

A

Non-response bias
Exclusion bias
Incidence-prevalence bias
Hospital admission bias

43
Q

More details about selection bias in case-control studies

A

More of a problem for case-control studies than some other study designs
Has often to do with how the controls are selected

44
Q

How can bias occur in selection of controls in a case-control study?

A

Controls may be selected into the study based in some way on the exposure, so that controls do not represent the source pop in terms of exposure status.
As a result, the relationship between exposure and dz among participants in the study differs from what the relationship would have been along individuals in the pop of interest.

45
Q

How to reduce selection bias among controls

A

Recruit controls from the same source pop as the cases
If unsure of the exact sampling frame, attempt to draw controls from a variety of sources.
Compare the prevalence of the exposure among controls with other sources to evaluate credibility

46
Q

How to reduce selection bias due to unrepresentative cases

A

Develop an explicit (objective) case definition
Enroll all cases in a defined time and region
Ensure that all medical facilities are thoroughly canvassed
Consider whether all cases require medical attention; consider possible strategies to ID where else the cases might be ascertained
Try to recruit incident (new) rather than prevalent (all) cases, if possible

47
Q

Common forms of selection bias in cohort studies

A

LTFU bias
Healthy worker effect

48
Q

How to minimize LTFU

A

Restricting the study participants to those likely to remain in the study
Collecting personal identifying info
Making periodic contact, and providing incentives
Recruiting a new cohort as time goes on to replace those LTFU (and who die)

49
Q

How to minimize healthy worker effect

A

Select a comparison group made up of a similar type of worker, who were unexposed

50
Q

Definition of information bias

A

Results from systematic differences in the way data on exposure or outcome are obtained from the various study groups
It is a bias in terms of the data itself and its ascertainment
Can be introduced as a result of systematic measurement error in assessment of either exposure and/or dz

51
Q

Types of information bias

A

Recall bias
Reporting bias
—Social desirability bias
—Wish bias
Interviewer/abstractor bias
Surrogate interview bias
Exposure suspicion bias
Detection bias

52
Q

Definition of recall bias

A

Occurs when one group remembers the past differently (more or less accurately) than the other

53
Q

Definition of reporting bias

A

Can occur whenever any self-reported data are collected. This is any incorrect information given by the respondents for whatever reason, intentional or unintentional

54
Q

Definition of social desirability bias

A

Aka the Clever Hans Effect or Obsequiousness Bias. A type of reporting bias in which participants lie about the data in order to please the interviewers

55
Q

Wish bias definition

A

A type of reporting bias in which cases seek to show that the dz was not their fault. Such participants deny certain negative lifestyle exposures, or overestimate workplace exposures. This form of bias may be unconscious.

56
Q

Interviewer/abstractor bias or observer/interviewer bias

A

Occurs when interviewers probe more thoroughly for an exposure or outcome in one comparison group than in the other (or when they abstract data more thoroughly in one group than another)

57
Q

When can interviewer/abstractor bias occur?

A

In any type of unblinded or single blinded study where there are two or more comparison groups
-Case-control studies
-Cohort studies
-Clinical trials that are not double blinded

58
Q

How to prevent interviewer/abstractor bias and the placebo effect

A

In a double-blind study neither the participants nor the investigators know who is receiving the active tx

59
Q

How to minimize interviewer/abstractor bias when there is no double blinding possible in observational studies

A

If interviewers do not know the exposure status of the participants, there may be less likelihood of this sort of bias (a kind of blinding)
Even if the interviewers are blinded as to who is exposed and who is not, the participants themselves know

60
Q

When does surrogate interview bias occur?

A

When participants are dead or unable to be interviewed, and surrogates are interviewed in their place

61
Q

Exposure suspicion bias definition

A

This type of information bias is closely related to, but not quite the same as interviewer/abstractor bias. It occurs when knowledge of cases’ and controls’ outcome status determines how the exposure is assessed.

62
Q

Detection bias definition

A

Aka surveillance bias. When one pop or group is monitored more thoroughly over time than the other

63
Q

Common forms of information bias in cross-sectional studies

A

Reporting bias
Recall bias
Surrogate interview bias

64
Q

Common forms of information bias in case-control studies

A

Reporting bias
Recall bias
Interviewer/abstractor bias
Surrogate interview bias
Exposure suspicion bias

65
Q

Common forms of information bias in cohort studies

A

Reporting bias
Interviewer/abstractor bias
Detection or surveillance bias

66
Q

What is the result of information bias?

A

People are misclassified into the wrong groups
Should be exposed but are listed as unexposed or vice versa
Or should be diseased but are listed as not diseased or vice versa
The right people are in your study, but under the wrong labels
Can occur in any study design

67
Q

What are two types of misclassification?

A

Non-differential (less serious)
Differential (more serious)

68
Q

Definition of non-differential misclassification

A

When the direction and extent of misclassification is equal between comparison groups. It occurs in both groups

69
Q

What does non-differential misclassification always bias?

A

Odds ratio, relative risk, prevalence ratio or correlation coefficient toward the null

70
Q

Differential misclassification definition

A

When the direction and/or extent of misclassification is not equal between comparison groups, or misclassification only occurs in one of the comparison groups

71
Q

What calculations can differential misclassification bias?

A

The odds ratio, relative risk, etc. in any direction

72
Q

Techniques to reduce information bias

A

Use memory aids to avoid recall bias
Validate exposures via medical records or blood tests as opposed to questioning the participant
Provide standardized training sessions and protocols for interviewer to avoid interviewer/abstractor bias
Use standardized data collection forms to avoid interviewer/abstractor bias
Blind or mask when possible in clinical trials

73
Q

What are key questions when evaluating an epidemiologic study in terms of information bias?

A

What bias might have been introduced into the findings by the approach to selection of participants?
How were the comparison groups chosen?
Were selection criteria clearly defined?
What were the response rates?
Were all of the participants in the sample used in the analysis of the article? Why were some left out?

74
Q

What are key questions when evaluating an epi study in terms of information bias?

A

Is there any evidence for bias by misclassification of the outcome or the exposure (information bias)?
Is there likely to be recall or reporting bias?
Could there be any interviewer/abstractor bias?
Were the measurement and classification methods consistent for all participants?

75
Q

When to control selection and information bias

A

Selection and information bias can only be prevented and controlled during the design (planning) and conduct of a study- not later
-Choice of a study population (selection)
-Methods of data collection (information)

Epidemiology (17 decks)

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