Module 10 - Viral Replication Strategies Flashcards
In order to replicate, what must all viruses do?
- Recognize host cells
- Make genome available to host cell machinery
- Replicate genome
- Make multiple copies of required proteins
- Assemble new viral particles
- Exit the cell
What is the consequence of viruses having a narrow host range?
They can only infect and replicate within specific cells
What determines the host range of a virus?
The interactions between viral and cellular proteins
What does the viral attachment protein do?
Interacts with the receptor on the host cell to allow entry
How come receptors cannot be eliminated to prevent infections?
These receptors are generally essential for the host cell
What is the cellular function of the CD4 receptor?
Immune cell interactions
What virus attaches to the CD4 receptor?
HIV (Retroviridae)
What is the cellular function of the ICAM-1 receptor?
Cell adhesion
Which virus attaches to the ICAM-1 receptor?
Rhinovirus (Picornaviridae)
What is the cellular function of the Bgp 1a receptor?
Cell adhesion
Which virus attaches to the Bgp 1a receptor?
MHV-A59 (Coronaviridae)
What is the cellular function of the CR2 receptor?
B-cell activation
Which virus attaches to the CR2 receptor?
Epstein-Barr virus (Herpesviridae)
What is the cellular function of the sialic acid receptor?
Various functions
Which viruses attaches to the sialic acid receptor?
Influenza virus (Orthomyxoviridae)
What is the cellular function of the OmpF receptor?
Transmembrane channel
Which virus attaches to the OmpF receptor?
T2 (Myoviridae)
What receptor does HIV (Retroviridae) bind to?
CD4
What receptor does Rhinovirus (Picornaviridae) bind to?
ICAM-1
What receptor does MHV-A59 (Coronaviridae) bind to?
Bgp 1a
What receptor does Epstein-Barr virus (Herpesviridae) bind to?
CR2
What receptor does Influenze virus (Orthomyxoviridae) bind to?
Sialic acid
What receptor does T2 (Myoviridae) bind to?
OmpF
What are bacteriophages?
Viruses that infect bacteria