modes of inheritance Flashcards
1
Q
autosomal dominant
A
- One faulty copy causes disease
- All generations
- 50% risk
- Males and females equally affected
2
Q
autosomal recessive
A
- 2 faulty copies to cause disease
- 1/4 risk
3
Q
x linked
A
- Lies on X chromosome
- No male to male transmission
- Half of males from female carrier will be affected
- Half of females from female carrier will be a carrier
- All of females from affected male will be affected
4
Q
x inactivation
A
- Half the cells will have the working gene on average
5
Q
penetrance in mendelian disorders
A
high
small environmental contirbution
6
Q
penetrance in multifactorial disease
A
low
genetic change is just another risk factor
7
Q
who is mitochondrial DNA inherited from
A
mother
