genetics and cancer

Question 1

cancer

Answer 1

disease of mosaicism largely cuased by post zygotic mutations

Question 2

characteristics cancer cells aquire

Answer 2

proliferation
evade immune response
acquire a vascular supply
avoid apoptosis
metastasis

Question 3

oncogene

Answer 3

mutated gene that has the ability to cause cancer

Question 4

driver mutation

Answer 4

mutations that drive carcinogenesis

Question 5

passenger mutations

Answer 5

incidental mutations that happen because the tumour is unstable

Question 6

dna methylation

Answer 6

process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription

Question 7

epigenetics

Answer 7

the study of changes in gene expression without a change in DNA sequence

Question 8

where does methylaiton usually occur

Answer 8

on cytosine bases just efore guanine bases

Question 9

histone

Answer 9

type of protein found in chromosome

Question 10

what does methylation prevent

Answer 10

transcription

Question 11

what do abnormalities of methylation cause

Answer 11

genetic disease