Mod12: Hypersensitivity Flashcards
Hypersensitivity allergic reactions
Which Type of hypersentitivity reaction is immediate?
Type I (immediate)
Hypersensitivity allergic reactions
In which type of Hypersensitivity allergic reaction do antigens crosslink with IgE antibodies?
Type I Hypersensitivity allergic reaction
Hypersensitivity allergic reactions
In Type I Hypersensitivity allergic reactions, the realease of with substances is triggered by the cross sensitivity of antigens with IgE antibodies?
Inflammatory mediators from mast cells
Hypersensitivity allergic reactions
What are examples of Type I Hypersensitivity allergic reactions?
Atopy
(Atopy: heightened immune responses to common allergens)
Urticaria-angioedema
True anaphylaxis!!!
Hypersensitivity allergic reactions - Type I
Which two subcategories is Type I hypersensitivity allergic reactions further subdivided into?
Atopic type I
Nonatopic type I
Hypersensitivity allergic reactions - Type I
Type I hypersensitivity allergic reactions that are IgE mediated, an that only affect the skin and respiratory tract are categorized as:
Atopic type I hypersensitivity allergic reactions
Include allergic rhinitis, dermatitis, and asthma
Hypersensitivity allergic reactions - Type I
Mild, Nonatopic type I hypersensitivity allergic reactions manifest as:
Urticaria
Angioedema
Hypersensitivity allergic reactions - Type I
Severe, Nonatopic type I hypersensitivity allergic reactions manifest as:
Anaphylaxis
This is when the IgE antibodies crosslink with the antigens
Massive inflammtory mediators will be released from the mast cells
Hypersensitivity allergic reactions - Hypersensitivity
Cytotoxic reactions are classified as which type of Hypersensitivity allergic reactions?
Type II hypersensitivity allergic reactions
Hypersensitivity allergic reactions - Hypersensitivity
Which antibodies mediate Type II (cytotoxic) hypersensitivity allergic reactions?
IgG antibodies
IgG bind to antigens on cell surface
Hypersensitivity allergic reactions - Hypersensitivity
In Type II (cytotoxic) hypersensitivity allergic reactions, what happens next after the IgG bind to antigens on cell surface
Activate classic complement pathway,
which causes cells Lysis
Hypersensitivity allergic reactions - Hypersensitivity
What are examples of Type II (cytotoxic) hypersensitivity allergic reactions?
Hemolytic transfusion reactions
Autoimmune hemolytic anemia
Heparin-induced thrombocytopenia
Hypersensitivity allergic reactions - Hypersensitivity
Which type of Hypersensitivity allergic reactions are immune complex hypersensitivity reactions calssified as:
Type III (immune complex) hypersensitivity reactions
Hypersensitivity allergic reactions - Hypersensitivity
In Type III (immune complex) hypersensitivity reactions, which complexes deposit in body tissues?
Antigen-antibody (IgG or IgM)
Hypersensitivity allergic reactions - Hypersensitivity
Which antibodies comprise the Antigen-antibody complexes responsible for Type III (immune complex) hypersensitivity reactions?
IgG or IgM
Hypersensitivity allergic reactions - Hypersensitivity
In Type III (immune complex) hypersensitivity reactions, what happens after antigen-antibody (IgG or IgM) complexes deposit in tissue?
Attract neutrophils to area
Release lysosomal enzymes and toxic products
Hypersensitivity allergic reactions - Hypersensitivity
Which are examples of Type III (immune complex) hypersensitivity reactions?
Arthus reaction
Serum sickness
Acute hypersensitivity pneumonitis
Hypersensitivity allergic reactions - Hypersensitivity
Delayed, cell mediated Hypersensitivity allergic reactions are classified as:
Type IV (Delayed, cell mediated) hypersensitivity allergic reactions