MOD S11 - Incomplete Neoplasia III Flashcards
1
Q
What is retinitis pigmentosum?
A
Confers an increased risk of skin cancers when exposed to UV rays in sunlight
2
Q
What is ataxia telangiectasia?
A
Defective response to radiation damage
Profound weakness to lymphoid malignancies
Usually die before 20
3
Q
What is Fanconi’s anaemia?
A
Sensitivity to DNA cross linking agents
Marrow hypo function
Multiple congenital abnormalities
Predisposition to cancer
4
Q
Through what gene is familial adenomatous polyposis inherited?
A
APC
5
Q
Name a gene mutation which increases susceptibility to breast cancer
A
BRCA1 and BRCA2
6
Q
Through what gene is Li Fraumeni syndrome inherited?
A
The gene for p53
7
Q
Give examples of genetic conditions which increase the risk of tumours
A
Retinitis (xeroderma) pigmentosum
Ataxia telangiectasia
Fanconi’s anaemia
