Mod 10 Med delivery Flashcards
What category of drug category falls under the category for the suffix -nium
LAMA
What category of drug category falls under the category for the suffix -erol
LABA
What category of drug category falls under the category for the suffix -one
ICS
What category of drug falls under the category for the suffix -nium
LAMA
What category of drug falls under the category for the suffix -ide
ICS
What are the clinical uses of Aerosols?
Humidify dry inspired gas, using water aerosol
- Sputum induction and to improve mobilization/clearance of respiratory secretions using bland aerosols
- Deliver aerosolized drugs (bronchodilators, anti inflammatories and antibiotics) to resp tract
100% Particle size and predicted lung deposition in the mouth?
100% deposition of particle sizes > 15 microns are in the mouth
100% Particle size and predicted lung deposition in the nose?
100% deposition of particle > 10 microns
What Particle size best reaches the upper airways?
5-10 micron range tend to deposit in UA and early generations
What Particle size best reaches the lower respiratory tract?
Particles 1-5 range able to reach LRT and lung periphery
- also called the respirable fraction
2 ways of quantifying central tendencys of drug admin?
Average particle size (MMAD) and variabiltiy of particle sizes (GSD)
What is the Mass Median Aerodynamic Diameter (MMAD)
Describes the average particle diameter (um)
- 50% of the particles are smaller and have less mass
- 50% of the particles are larger and have greater mass
What are advantages of Aerosolized Meds?
onset is rapid as drug is delivered to the intended target area (resp tract)
- small doses
- Fewer systemic side effects w/less severe with oral/parenteral therapy
- inhaled drug therapy is painless and convenient
What are disadvantages of Aerosolized Meds?
- Difficulty in dose estimation and dose reproducibility
- Lack of technical info on
- Inconsistency on device use on pt
- infection
What is effective aerosol therapy?
Delivers adequate amount of drug to site of action
- min waste
- low cost
Routes/devices that can deliver aerosol therapy?
- Hand bulb atomizers
- nebulizers
- Inhalers (MDI and DPI)
What are Hand Bulb Atomizers used for?
- hint high MMAD and GSD
Suspension in Upper airway deposition for:
- Upper airway inflammation
- Rhinitis (steroids)
- Local anesthesia
3 types of Nebulizer routes?
- what do they most commonly contain?
SVN, USN, SPAG all generally contain:
- reservoir chamber
- Baffle or similar mech
Need to add slides 29-69
When would you select a SVN for use?
Patient preference/home use , formulation of drug, and
Emergency
- Unable to follow instructions/disoriented
- Tachypneic (>25bpm)/unstable respiratory pattern
- Poor inspiratory capacity
- Incapable of breath hold
When would you select a MDI for use?
- Able to follow instructions / demonstrate correct use
- Adequate inspiratory capacity
- Capable of breath hold
- Stable respiratory pattern
- Drug available in MDI form
- Use reservoir device
When would you select a DPI for use?
- Drug available in DPI form
- Poor MDI coordination
- Sensitive to propellants
- Capable of generating high inspiratory flow rates (> 30-60 lpm) depending on drug
- Need accurate dose count monitoring
What are complications PEDs have compared to adults?
- Smaller tracheal diameter
- Shorter trachea
- Higher RR
- Lower MV
- Lower deadspace
- Lower inspiratory flow rate
Why do pediatrics < 12 generally have less deposition of inhaled medication to the lower airways?
Smaller diameter of airways
