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Interventions 2 (RESP 319) > Mod 10 Med delivery > Flashcards

Mod 10 Med delivery Flashcards

1
Q

What category of drug category falls under the category for the suffix -nium

A

LAMA

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2
Q

What category of drug category falls under the category for the suffix -erol

A

LABA

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3
Q

What category of drug category falls under the category for the suffix -one

A

ICS

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4
Q

What category of drug falls under the category for the suffix -nium

A

LAMA

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5
Q

What category of drug falls under the category for the suffix -ide

A

ICS

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6
Q

What are the clinical uses of Aerosols?

A

Humidify dry inspired gas, using water aerosol

  • Sputum induction and to improve mobilization/clearance of respiratory secretions using bland aerosols
  • Deliver aerosolized drugs (bronchodilators, anti inflammatories and antibiotics) to resp tract
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7
Q

100% Particle size and predicted lung deposition in the mouth?

A

100% deposition of particle sizes > 15 microns are in the mouth

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8
Q

100% Particle size and predicted lung deposition in the nose?

A

100% deposition of particle > 10 microns

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9
Q

What Particle size best reaches the upper airways?

A

5-10 micron range tend to deposit in UA and early generations

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10
Q

What Particle size best reaches the lower respiratory tract?

A

Particles 1-5 range able to reach LRT and lung periphery

  • also called the respirable fraction
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11
Q

2 ways of quantifying central tendencys of drug admin?

A

Average particle size (MMAD) and variabiltiy of particle sizes (GSD)

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12
Q

What is the Mass Median Aerodynamic Diameter (MMAD)

A

Describes the average particle diameter (um)

  • 50% of the particles are smaller and have less mass
  • 50% of the particles are larger and have greater mass
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13
Q

What are advantages of Aerosolized Meds?

A

onset is rapid as drug is delivered to the intended target area (resp tract)

  • small doses
  • Fewer systemic side effects w/less severe with oral/parenteral therapy
  • inhaled drug therapy is painless and convenient
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14
Q

What are disadvantages of Aerosolized Meds?

A
  • Difficulty in dose estimation and dose reproducibility
  • Lack of technical info on
  • Inconsistency on device use on pt
  • infection
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15
Q

What is effective aerosol therapy?

A

Delivers adequate amount of drug to site of action

  • min waste
  • low cost
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16
Q

Routes/devices that can deliver aerosol therapy?

A
  • Hand bulb atomizers
  • nebulizers
  • Inhalers (MDI and DPI)
17
Q

What are Hand Bulb Atomizers used for?

  • hint high MMAD and GSD
A

Suspension in Upper airway deposition for:

  • Upper airway inflammation
  • Rhinitis (steroids)
  • Local anesthesia
18
Q

3 types of Nebulizer routes?

  • what do they most commonly contain?
A

SVN, USN, SPAG all generally contain:

  • reservoir chamber
  • Baffle or similar mech
19
Q

Need to add slides 29-69

A
20
Q

When would you select a SVN for use?

A

Patient preference/home use , formulation of drug, and
Emergency

  • Unable to follow instructions/disoriented
  • Tachypneic (>25bpm)/unstable respiratory pattern
  • Poor inspiratory capacity
  • Incapable of breath hold
21
Q

When would you select a MDI for use?

A
  • Able to follow instructions / demonstrate correct use
  • Adequate inspiratory capacity
  • Capable of breath hold
  • Stable respiratory pattern
  • Drug available in MDI form
  • Use reservoir device
22
Q

When would you select a DPI for use?

A
  • Drug available in DPI form
  • Poor MDI coordination
  • Sensitive to propellants
  • Capable of generating high inspiratory flow rates (> 30-60 lpm) depending on drug
  • Need accurate dose count monitoring
23
Q

What are complications PEDs have compared to adults?

A
  • Smaller tracheal diameter
  • Shorter trachea
  • Higher RR
  • Lower MV
  • Lower deadspace
  • Lower inspiratory flow rate
24
Q

Why do pediatrics < 12 generally have less deposition of inhaled medication to the lower airways?

A

Smaller diameter of airways

25
Q
A

Interventions 2 (RESP 319) (25 decks)

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