Mod. 1 Chapter 10 Review Questions And Ppt Flashcards
The megakaryocyte progenitor that undergoes endomitosis is:
A. BFU-Meg
B. MK-1
C. LD-CFU-Meg
D. CFU-Meg
C. LD-CFU-Meg
The growth factor that is produced in the kidney and induces growth and differentiation of commited megakaryocyte progenitor is:
A. IL-3
B. IL-6
C. IL-11
D. Thrombopoietin
D. Thrombopoietin
What platelet organelle sequesters ionic calcium and binds a series of enzymes of the eicosanoid pathway?
A. Dense granules
B. Dense tubular system
C. Surface connected cannicular system
D. Glycocalyx
B. Dense tubular system
White clots are:
A. Largely composed of platelets and VWF
B. Occur primarily in the deep veins of the legs
C. Characteristic of the secondary hemostatic process
D. Form normally in response to vascular injury and are completely harmless
A. Largely composed of platelets and VWF
What platelet membrane receptor binds fibrinogen and supports platelets aggregation?
A. GP Ib/IX/V
B. GP Ia/IIa
C. GP IIb/IIIa
D. P2Y1
C. GP IIb/IIIa
What platelet membrane phospholipid flips from the inner surface to the plasma surface on activation and serves as the assembly point of coagulation factors?
A. Phosphatidylethanolamine
B. Phosphatidylinositol
C. Phosphatidylserine
D. Phosphatidylcholine
C. Phosphatidylserine
Reticulated platelets can be enumerated in peripheral blood to detect:
A. Impaired platelet production in disease states
B. Abnormal organelles associated with diseases such as leukemia
C. Increased platelet production in response to need
D. Inadequate rates of membrane cholesterol exchange with the plasma
C. Increased platelet production in response to need
What plasma protein is essential for platelet adhesion?
A. Von willebrand factor
B. Factor VIII
C. Fibrinogen
D. P-selectin
A. Von willebrand factor
Which of the following molecules is stored in platelet dense granules?
A. Fibrinogen
B. Serotonin
C. Platelet factor 4
D. Platelet derived growth factor
B. Serotonin
What is the name of the eicosanoid metabolite produced from endothelial cells that suppresses platelet activity?
A. Thromboxane A2
B. Arachidonic acid
C. Cyclooxygenase
D. Prostacyclin
D. Prostacyclin
Microparticles:
A. Are stored in platelet dense granules
B. Inhibit blood clotting
C. Bud off of platelets after their exposure to strong agonist
D. Exhibit no biologic activity
C. Bud off of platelets after their exposure to strong agonist
Upon activation, platelets secrete their a-granule contents via:
A. The dense tubular system
B. The surface connected cannicular system
C. The glycocalyx
D. Microtubules
B. The surface connected cannicular system
Enumerate the 3 types of blood vessels
- arteries and veins
- arterioles and venules
- capillaries
______ is a reflex in which blood vessels narrow to increase blood pressure
Vasoconstriction
_____ and _____ promotes vasoconstriction
Epinephrine and serotonin
_______ causes vasoconstriction
Thromboxane A2
_____ ensures rapid lysis of fibrin clots
Plasminogen
______ Acts as modulators of vasomotor tone, cell proliferation, and hormone production
Endothelins
Which of the 3 members of the endothelin family is produced in endothelial cells and is also produced in vascular smooth muscle cells?
Endothelin 1
Which of the 3 members of the endothelin family is produced predominantly in kidney and intestine, with smaller amounts produced in the myocardium, placenta and uterus
Endothelin 2
Which of the 3 members of the endothelin family has been found in high concentration in the brain and is also found throughout the gastrointestinal tract and in the lung and kidney?
Endothelin 3
____ play an important role in the initiation, progression, and clinical complications of various forms of inflammatory and degenerative vascular diseases
Endothelial dysfunction
_______ is the hormone thought to stimulate the production and maturation of megakaryocytes
Thrombopoietin
Megakaryoblast
Size:______
Nucleus:_______
N/C ratio:_____
10-24mm
Round
3:1
Promegakaryocyte
Size:______
Nucleus:_____
N/C ratio: ______
15-40mm
Indented
1:2
Megakaryocyte
Size: _____
Nucleus:_____
N/C ratio:_____
Up to 160mm
Multilobe
1:4
______ surrounds the cellular membrane of the platelet externally
Glycocalyx / fluffy coat
An average megakaryocyte produces about ____ to ____ platelets
1000 to 2000
Maturation period of megakaryocyte is
5 days
Platelets initially enter the spleen and remains for how many days?
2
The life span of a mature platelet is
9.0 days ± 1day
A normal person has an average of ______ platelets in the systemic circulation
250 x 10^9/L
(pero nag rerange siya 150 to 450 x 10^9/L)
