Mock SAQs 2 Flashcards
A 51-year old man present is referred by his GP to an endocrinologist for suspected acromegaly.
What is the most common cause of acromegaly?
GH secreting pituitary tumour
A 51-year old man present is referred by his GP to an endocrinologist for suspected acromegaly.
List three symptoms of acromegaly?
- Excessive sweating
- Decreased libido
- Headaches
- Muscular weakness
- Thickening skin
A 51-year old man present is referred by his GP to an endocrinologist for suspected acromegaly.
What is the diagnostic test for acromegaly?
Glucose tolerance test
A 51-year old man present is referred by his GP to an endocrinologist for suspected acromegaly.
The diagnosis of acromegaly is confirmed. What are the two groups of pharmacological therapies that he could be prescribed?
GH antagonists
Somatostatin analogues
Dopamine agonists
A 51-year old man present is referred by his GP to an endocrinologist for suspected acromegaly.
Name two associated comorbidities of acromegaly?
Hypertension Arthritis Obstructive sleep apnoea Heart diease Impaired glucose tolerance Diabetes
A 48-year old woman present to A&E with a sharp, severe chest pain that is by relieved sitting forwards. The doctor suspects pericarditis.
What are two differential diagnoses for pericarditis?
Acute coronary sydrome Aortic dissection Gastric ulcer Oesophagitis Pancreatitis Pneumonia Pleuritis
A 48-year old woman present to A&E with a sharp, severe chest pain that is by relieved sitting forwards. The doctor suspects pericarditis.
Name an investigations that should be carried out in this patient and it’s results?
ECG
Saddle shaped ST elevation
PR depression
A 48-year old woman present to A&E with a sharp, severe chest pain that is by relieved sitting forwards. The doctor suspects pericarditis.
What drug can be given to reduce the chance of recurrence of pericarditis?
Colchichine
A 48-year old woman present to A&E with a sharp, severe chest pain that is by relieved sitting forwards. The doctor suspects pericarditis.
Three complications of pericarditis?
Pericardial effusion
Cardiac tamponade
Constrictive pericarditis
A 20-year old woman has been recently diagnosed with iron deficiency anaemia.
What type of anaemia is iron deficient anaemia?
Microcytic
A 20-year old woman has been recently diagnosed with iron deficiency anaemia.
What are two causes of iron deficient anaemia?
Poor iron intake
Malabsorption
Increased demands i.e growth and pregnancy
A 20-year old woman has been recently diagnosed with iron deficiency anaemia.
What are three symptoms of anaemia?
Fatigue Lethargy Dyspnoea Palpitation Intermittent claudication
A 20-year old woman has been recently diagnosed with iron deficiency anaemia.
How is iron transported in the blood and how is it stored?
Transported bound to transferrin and stored as ferritin
A 40-year old man is suffering with dyspepsia and epigastric tenderness during and just after eating. His GP suspects a peptic ulcer.
What are 3 causes of peptic ulcers?
NSAIDs
Smoking
Mucosal ischaemia
Increased gastric secretion
A 40-year old man is suffering with dyspepsia and epigastric tenderness during and just after eating. His GP suspects a peptic ulcer.
From his presentation, where do you expect is peptic ulcer to be and why?
Stomach, his epigastric tenderness is during eating/after, intestinal would be a when hungry, duodenal at night
A 40-year old man is suffering with dyspepsia and epigastric tenderness during and just after eating. His GP suspects a peptic ulcer.
What drug group can be used to reduce gastric acid secretion?
Proton pump inhibitors
A 40-year old man is suffering with dyspepsia and epigastric tenderness during and just after eating. His GP suspects a peptic ulcer.
What is a complication of peptic ulceration?
Bleeding
A 22-year old man has gradual onset back and buttock pain that is relieved somewhat on exercise. He is referred to a rheumatologist and ankylosing spondylitis is diagnosed.
What group of inflammatory joint disorders does this fall under?
Spondyloarthropathy
A 22-year old man has gradual onset back and buttock pain that is relieved somewhat on exercise. He is referred to a rheumatologist and ankylosing spondylitis is diagnosed.
What genetic association to these conditions share?
HLA-B27 association
A 22-year old man has gradual onset back and buttock pain that is relieved somewhat on exercise. He is referred to a rheumatologist and ankylosing spondylitis is diagnosed.
Other than the features listed, name two other features of this condition?
Psoriasis Enthesitis Dactylitis Crohns UC Eye involvement
A 22-year old man has gradual onset back and buttock pain that is relieved somewhat on exercise. He is referred to a rheumatologist and ankylosing spondylitis is diagnosed.
What is the first sign on x ray of this condition?
Sacroilitis
A 22-year old man has gradual onset back and buttock pain that is relieved somewhat on exercise. He is referred to a rheumatologist and ankylosing spondylitis is diagnosed.
Name three means of management for this condition?E
Excercise
Phyisotherapy
NSAIDS
TNF-alpha blockers
A woman presents to A+E with acute kidney injury.
What are two different diagnostic criteria for this condition?
Rise in creatinine 1.5x the baseline
<0.5ml/kg/hr for >6 hours §
A woman presents to A+E with acute kidney injury.
What are two risk factors for acute kidney injury?
Old age CKD Cardiac failure PVD Sepsis Poor fluid intake/loss
A woman presents to A+E with acute kidney injury.
Name 2 pre renal and 2 renal causes of acute kidney injury?
Pre: hypotension, hypovoleimia, renal artery stenosis
Renal: Acute tubular necrosis, glomerulonephritis, drugs, vasculitis, autoimmune
A woman presents to A+E with acute kidney injury.
Why might hyperkalaemia occur in AKI?
It causes reduced renal excretion of potassium
A 70 year old man has had a recent diagnosis of parkinsons diesease.
What are two histological findings that you can see in a person with PD?
Lewy bodies
Degeneration of dopaminergic neurons
A 70 year old man has had a recent diagnosis of parkinsons diesease.
What are two characteristic signs in the gait of a person with PD?
Shuffling
Reduced arm swing
Slow to get going
A 70 year old man has had a recent diagnosis of parkinsons diesease.
What are the dopaminergic changes seen in PD?
Reduced dopamine in the substantia nigra
A 70 year old man has had a recent diagnosis of parkinsons diesease.
List 2 pharmacological strategies to manage PD?
L dopa
Dopamine agonists
COMT/MAO-V inhibitors
A 60-year old lady present to her GP with a mark on her nose that she is concerned could be cancer. The GP examines it and describes it as a pearly papule with rolled edges.
What type of cancer is it most likely to be?
Basal cell carcinoma
A 60-year old lady present to her GP with a mark on her nose that she is concerned could be cancer. The GP examines it and describes it as a pearly papule with rolled edges.
What are three risk factors for skin cancer?
UV light
Family history
Pale skin
A 60-year old lady present to her GP with a mark on her nose that she is concerned could be cancer. The GP examines it and describes it as a pearly papule with rolled edges.
What is the first line treatment for any skin cancer?
Surgical excision
A 60-year old lady present to her GP with a mark on her nose that she is concerned could be cancer. The GP examines it and describes it as a pearly papule with rolled edges.
Malignant melanoma is more aggressive than skin cancer, name four features of a melanoma lesion that would point towards its diagnosis?
Pigmented Asymmetrical Border irregularity Colour irregularity Changes over time Diameter >6mm
A 19-year old boy present to his GP with a continuous low mood and sadness and he is concerned he may have depression. The GP agrees and prescribes him some medication that may help, he is booked another consultation for 4-week time.
What are three risk factors for depression?
History Grief Conflict Abuse Life events Illness Medication
A 19-year old boy present to his GP with a continuous low mood and sadness and he is concerned he may have depression. The GP agrees and prescribes him some medication that may help, he is booked another consultation for 4-week time.
How does depression manifest physically - give three examples?
Moving slowly Changes in appetite Constipation Lack of energy Loss of libido Changes to menstrual cycle Disturbed sleep
A 19-year old boy present to his GP with a continuous low mood and sadness and he is concerned he may have depression. The GP agrees and prescribes him some medication that may help, he is booked another consultation for 4-week time.
Name two types of medication that the GP could of prescribed him?
Selective serotonin reuptake inhibitors
Tricyclic antidepressants
Monoamine oxidase inhibitors
A 19-year old boy present to his GP with a continuous low mood and sadness and he is concerned he may have depression. The GP agrees and prescribes him some medication that may help, he is booked another consultation for 4-week time.
What should the GP warn the patient about when prescribing anti-depressants?
You may feel worse in the short term, any suicidal thoughts and he should come back
A 19-year old boy present to his GP with a continuous low mood and sadness and he is concerned he may have depression. The GP agrees and prescribes him some medication that may help, he is booked another consultation for 4-week time.
3 non pharmalogical therapies for depression?
Mindfullness
Depression
CBT
Excercise
10-year old child presents to her GP practice unwell with a one-day history of fever, drowsiness, photophobia and neck stiffness. The doctor suspects meningitis.
What is the most common organism to cause meningitis?
Strepococcus pneumoniae
10-year old child presents to her GP practice unwell with a one-day history of fever, drowsiness, photophobia and neck stiffness. The doctor suspects meningitis.
What could would streptococcus pneumoniae stain with gram stain?
Pink
10-year old child presents to her GP practice unwell with a one-day history of fever, drowsiness, photophobia and neck stiffness. The doctor suspects meningitis.
The GP calls for an ambulance for the child to go to hospital, what else should he do?
Give IM benzylpenicillin
10-year old child presents to her GP practice unwell with a one-day history of fever, drowsiness, photophobia and neck stiffness. The doctor suspects meningitis.
At the hospital a lumbar puncture is carried out, it confirms that the organism is a bacteria, what features from analysis may indicate this?
Cloudy Neutrophils Gram film visible High protein Low glucose
10-year old child presents to her GP practice unwell with a one-day history of fever, drowsiness, photophobia and neck stiffness. The doctor suspects meningitis.
In what case would a lumbar puncture be contraindicated in meningitis?
If septicaemia is indicated i.e. rash
80-year old woman in referred to a urology clinic due to stress incontinence.
What is stress incontinence?
Involuntary emission of urine when pressure in the abdomen increases suddenly
80-year old woman in referred to a urology clinic due to stress incontinence.
What anatomical differences make stress incontinence more likely in women?
Only one sphincter
Shorter urethra
80-year old woman in referred to a urology clinic due to stress incontinence.
What are three other types of incontinence?
Urgency, mixed, continuous and overflow
80-year old woman in referred to a urology clinic due to stress incontinence.
First line of management for stress incontinence?
Pelvic floor exercises
A 54-year-old man goes to see his GP regularly for his annual diabetic
review. The doctor takes his blood pressure which is shown to be
145/93mmHg
List three other risk factors for hypertension?
Family history Lack of physical activity Obesity High salt intake Smoking High alcohol intake
A 54-year-old man goes to see his GP regularly for his annual diabetic
review. The doctor takes his blood pressure which is shown to be
145/93mmHg
What blood pressure should be aimed for someone with diabetes mellitus?
<130/80mmHg
A 54-year-old man goes to see his GP regularly for his annual diabetic
review. The doctor takes his blood pressure which is shown to be
145/93mmHg
List two complications of hypertension?
Retinopathy Heart failure Ischaemic heart disease Renal failure Headache Nausea Impotence
A 54-year-old man goes to see his GP regularly for his annual diabetic
review. The doctor takes his blood pressure which is shown to be
145/93mmHg
What type of medication should be given to treat HTN given an example?
ACEi
Rampril
A 54-year-old man goes to see his GP regularly for his annual diabetic
review. The doctor takes his blood pressure which is shown to be
145/93mmHg
Name a test that could be done to assess potential organ damage from hypertension, name the test and result?
Echo or ECG - LV hypertrophy or past MI
Urine analysis- shows proteinuria to check kidney function
Fundoscopy - asses hypertensive retinopathy
A 25-year-old female comes into A&E unable to breath, in and out of
consciousness. Her family member says she was stung by a bee but
weren’t aware she was allergic to anything. However she does have
eczema and her mother has asthma. The doctors suspect she has
undergone anaphylaxis.
List 2 signs that the doctors would look for to determine if its indeed anaphylaxis
Lowered bP Dyspnoea due to bronchoconstriction Rash Swelling Vomiting
A 25-year-old female comes into A&E unable to breath, in and out of
consciousness. Her family member says she was stung by a bee but
weren’t aware she was allergic to anything. However she does have
eczema and her mother has asthma. The doctors suspect she has
undergone anaphylaxis.
What type of hypersensitivity is anaphylaxis?
Type 1
A 25-year-old female comes into A&E unable to breath, in and out of
consciousness. Her family member says she was stung by a bee but
weren’t aware she was allergic to anything. However she does have
eczema and her mother has asthma. The doctors suspect she has
undergone anaphylaxis.
What immunoglobulin is involved in allergic reactions?
IgE
A 25-year-old female comes into A&E unable to breath, in and out of
consciousness. Her family member says she was stung by a bee but
weren’t aware she was allergic to anything. However she does have
eczema and her mother has asthma. The doctors suspect she has
undergone anaphylaxis.
Briefly expain the mechanism of re exposure in anaphylaxis?
Allergen binds to IgE
Receptor cross linking causes a cascade
Mast cell degranulation of histamine
A 25-year-old female comes into A&E unable to breath, in and out of
consciousness. Her family member says she was stung by a bee but
weren’t aware she was allergic to anything. However she does have
eczema and her mother has asthma. The doctors suspect she has
undergone anaphylaxis.
What dosage route and drug would be given?
300mg
IM
Adrenaline
50-year-old man comes into his GP. The patient complaints of Lower
urinary tract symptoms. The doctor performs a digital rectal exam and
finds his prostate to be smooth and enlarged; he suspects benign prostatic
hyperplasia.
What is the pathophysiology of BPH?
Benign nodular or diffuse proliferation
Of muculofibrous and glandular layers of prostate
Inner /transitional zone enlarges
50-year-old man comes into his GP. The patient complaints of Lower
urinary tract symptoms. The doctor performs a digital rectal exam and
finds his prostate to be smooth and enlarged; he suspects benign prostatic
hyperplasia.
Name on storage and one voiding LUTS?
Storage: Frequency, urgency, nocturia
Voiding: Stream poor, Hesitancy, Incomplete emptying, Post micturition dribble
50-year-old man comes into his GP. The patient complaints of Lower
urinary tract symptoms. The doctor performs a digital rectal exam and
finds his prostate to be smooth and enlarged; he suspects benign prostatic
hyperplasia.
List three differentials of LUTS?
UTI
Porstatis
Prostate cancer MS
Diuretic medication
50-year-old man comes into his GP. The patient complaints of Lower
urinary tract symptoms. The doctor performs a digital rectal exam and
finds his prostate to be smooth and enlarged; he suspects benign prostatic
hyperplasia.
Name an investigation that could be done to differentiate from malignancy?
Prostate specific antigen - shouldn’t be too high however can be raised if BPH large
Transrectal ultrasound and biopsy - histology of biopsy
A 4-year-old girl has been brought in, to see the GP, by her mother. On
examination there are itchy, erythematous and scaly patches on her skin.
These are locates on her cheeks and in the flexure of her elbows. Her skin
in general is seen to be quite dry. The mother explains how they
themselves have asthma and that their child has been recently diagnosed
with asthma too.
What is the most likely diagnosis of this child’s complaint|?
Atopic eczema
A 4-year-old girl has been brought in, to see the GP, by her mother. On
examination there are itchy, erythematous and scaly patches on her skin.
These are locates on her cheeks and in the flexure of her elbows. Her skin
in general is seen to be quite dry. The mother explains how they
themselves have asthma and that their child has been recently diagnosed
with asthma too.
|n acute lesions, Staph auerus common, name a test an result to confirm this?
Gram - positive
Coagulase - positive
A 4-year-old girl has been brought in, to see the GP, by her mother. On
examination there are itchy, erythematous and scaly patches on her skin.
These are locates on her cheeks and in the flexure of her elbows. Her skin
in general is seen to be quite dry. The mother explains how they
themselves have asthma and that their child has been recently diagnosed
with asthma too.
Describe the cause of eczema?
Loss of natural moisturising factors causes cracks in the skin
Abnormal lipid bilayer provides inaqudate permeability barrier