Mobility part 2 Flashcards
The most prevalent bone disease in the world?
osteoporosis
means porous bone, is a disease in which the density and quality of bone are reduced.
osteoporosis
a disease of the bones that happens when you lose too much bone, make too little bone or both.
osteoporosis
low bone density, middle ground, not enough bone density lost to be diagnosed as osteoporosis
osteopenia
break down bone
ostoeclasts
rebuild bone
osteoblasts
What medication risk factors are there for osteoporosis?
- steroids
- anti-seizure
- antacids
- chemotherapy drugs
What disease risk factors are there for osteoporosis?
–Anorexia
–Malabsorption syndrome
–Chronic Kidney failure
– Measures bone mineral density (BMD)
– Recommended for ALL women >65yrs
– Post-Menopausal women >50yrs w/risk factors
Dual-energy x-ray absorptiometry (DEXA)
10 year probability of getting a fracture based on assessment
Fracture Risk Assessment Tool (FRAX)
What are osteoporosis medication treatment?
- Calcium and Vitamin D supplements
- Raloxifene Hydrochloride (Evista)
- Calcitonin
- Bisphosphonates
- Teriparatide (Forteo)
- Denosumab (Prolia)
– Inhibits bone breakdown (osteoclast activity)
– Available as a daily, weekly, monthly or yearly
dose
– Potential side effects: GI symptoms –dyspepsia,
nausea, flatulence, diarrhea and constipation
• Take on an empty stomach
• Take with a full glass of water
• Stay upright for 30-60 minutes after ingestion
– Do NOT take at the same time as Calcium
Bisphosphonates
–Selective Estrogen Receptor Modulator (SERM) – mimics natural estrogen without increasing cancer effects from estrogen –Inhibits bone breakdown (osteoclast activity) –Side Effects: Increase risk of blood clots, hot flashes
• Raloxifene Hydrochloride (Evista)
–Inhibits bone breakdown (osteoclast activity) and
stimulates bone formation (osteoblasts)
–Available as an injection or nasal spray
–No major side effects
*good option
Calcitonin
– Synthetic Parathyroid Hormone – stimulates
formation of bone (osteoblast activity)
– For use with:
• Men and postmenopausal women with
osteoporosis at high risk for fractures
• Men and women with chronic steroid use
• Those unable to take other osteoporosis
medications
– Can’t take for more than 2 years in a lifetime
– Side effect: orthostatic hypotension, joint and
muscle pain and weakness, nausea
– Daily Subcutaneous Injection
Teriparatide (Forteo)
– Inhibits bone breakdown (osteoclasts) – For osteoporosis with a high risk of fractures OR can’t use other osteoporosis medications OR other medications were not effective – Contraindicated with low blood calcium levels – Side effects: jaw bone necrosis, thigh fractures, serious infections
Denosumab (Prolia)
Which types of treatment medications are there available for osteoporosis?
- Denosumab (Prolia)
* Teriparatide (Forteo)
What are fractures?
- Break in the continuity of a bone
* Can happen to any bone in the body
– Break is across entire width of the bone
complete fracture
– Break is through only part of the bone, and the other side is bent
incomplete fracture (greenstick)
– Produces bone fragments
Comminuted Fracture
– No break in the skin
Closed Fracture aka Simple Fracture
– Bone breaks through the skin or mucus
membranes
Open Fracture aka Compound Fracture
How are gustilo open (compound) fractures classified?
- Grade I
- Grade II
- Grade III
– Least severe
– Wound < 1 cm
– Wound is clean
Grade I
– Wound >1 cm and < 10 cm
– Without extensive soft tissue damage
Grade II
– Most severe injury and mostly > 10cm – Extensive soft tissue damage – Highly Contaminated Wound – May also have nerve or vascular damage or associated with a traumatic amputation
Grade III
a fracture that remains contained, with no disruption of the skin integrity
simple fracture
a fracture in which damage also involves the skin or mucous membranes, also called a compound fracture
open fracture
a fracture occurring at an angle across the bone (less stable than a transverse fracture)
oblique fracture