MOA of Hypertensive Medications

Question 0

Loop diuretics MOA

Answer 0

Inhibit active transport of sodium, chloride, and potassium in thick ascending limb of loop of henle causing excretion of these ions. Collecting duct excretes more water in response

Question 1

Thiazides MOA

Answer 1

Inhibits sodium reabsorption in distal tubule

Question 2

Aldosterone receptor blockers MOA

Answer 2

Competes with aldosterone and prevents sodium reabsorption and potassium excretion

Question 3

Potassium sparing drugs MOA

Answer 3

Blocks sodium reabsorption and potassium excretion, effect independent of aldosterone

Question 4

ACE-I MOA

Answer 4

Inhibits ACE which usually produces angiotensin 2
Also inhibits breakdown of bradykinin (vasodilator)
Dilate the efferent arteriole of kidney

Question 5

ARB MOA

Answer 5

Inhibits angiotensin 2 at its receptor sites

Does NOT inhibit the breakdown of bradykinin