MoA of drugs Flashcards
SSRIs
Selectively decreases the action of 5-HT reuptake pump, leading to increase serotonin levels in the synapse
What are the SSRIs
Sertraline, citalopram, escitalopram, fluoxetine, paroxetine, fluvoxamie
SNRIs MoA
Blocks reuptake of 5-HT and norepinephrine (NE), increasing their levels in the synapse
SNRI examples
Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran
Buproprion MoA
MOA → Acts as a dopamine-norepinephrine reuptake inhibitor (also antagonizes nicotinic receptors)
Mirtazapine MoA
Antagonizes alpha-2 adrenergic receptors and 5-HT2 and 5-HT3 receptors, which causes increased release of serotonin and norepinephrine
Serotonin Modulators
block reuptake of 5-HT
Nefazodone and trazodone
serotonin modulator
antagonize 5-HT receptors, causing increased release of serotonin & block reuptake of serotonin
Vilazodone and vortioxetine
Serotonin modulators
are partial agnoists of serotonin but also block reuptake of serotonin
Ketamine
Opioid and AMPA (glutamate) agonist, NMDA antagonist
MAOI
a- breaks down serotonin and norepinephrine
b- works with MAOa to break down dopamine
MAOIs
Tranylcypromine (Parnate)
Phenelzine (Nardil)
Isocarboxazid (Marplan)
Selegiline (Eldepryl
TCAs
Inhibits reuptake of 5-HT and norepinephrine (NE)
Tertiary leans heavier on the serotonin while secondary leans heavier on the NE
TeCAs
similar to TCA MoA, - have an extra cyclic ring
Maproltiline
Maprotiline (Ludiomil)
MOA: Blocks reuptake of NE and 5-HT (more potent for 5-HT)
Amoxapine
Blocks reuptake of NE; blocks dopamine receptors (antipsychotic)
Name antipsychotics
addons for antidepressants
Aripiprazole, brexpiprazole, quetiapine
Benzodiazepines
Enhance the effect of GABA at the GABA receptor
Hydroxyzine
Histamine H1 receptor antagonist
Buspirone
5HT1a receptor agonist; also acts on dopamine receptors
Prazosin (Minipress)
Prazosin (Minipress) - α1-adrenergic blocker - insomnia
