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Hunts BD > MoA of drugs > Flashcards

MoA of drugs Flashcards

1
Q

SSRIs

A

Selectively decreases the action of 5-HT reuptake pump, leading to increase serotonin levels in the synapse

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2
Q

What are the SSRIs

A

Sertraline, citalopram, escitalopram, fluoxetine, paroxetine, fluvoxamie

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3
Q

SNRIs MoA

A

Blocks reuptake of 5-HT and norepinephrine (NE), increasing their levels in the synapse

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4
Q

SNRI examples

A

Venlafaxine, Desvenlafaxine, Duloxetine, Milnacipran

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5
Q

Buproprion MoA

A

MOA → Acts as a dopamine-norepinephrine reuptake inhibitor (also antagonizes nicotinic receptors)

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6
Q

Mirtazapine MoA

A

Antagonizes alpha-2 adrenergic receptors and 5-HT2 and 5-HT3 receptors, which causes increased release of serotonin and norepinephrine

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7
Q

Serotonin Modulators

A

block reuptake of 5-HT

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8
Q

Nefazodone and trazodone

A

serotonin modulator
antagonize 5-HT receptors, causing increased release of serotonin & block reuptake of serotonin

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9
Q

Vilazodone and vortioxetine

A

Serotonin modulators
are partial agnoists of serotonin but also block reuptake of serotonin

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10
Q

Ketamine

A

Opioid and AMPA (glutamate) agonist, NMDA antagonist

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11
Q

MAOI

A

a- breaks down serotonin and norepinephrine

b- works with MAOa to break down dopamine

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12
Q

MAOIs

A

Tranylcypromine (Parnate)
Phenelzine (Nardil)
Isocarboxazid (Marplan)
Selegiline (Eldepryl

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13
Q

TCAs

A

Inhibits reuptake of 5-HT and norepinephrine (NE)
Tertiary leans heavier on the serotonin while secondary leans heavier on the NE

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14
Q

TeCAs

A

similar to TCA MoA, - have an extra cyclic ring

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15
Q

Maproltiline

A

Maprotiline (Ludiomil)
MOA: Blocks reuptake of NE and 5-HT (more potent for 5-HT)

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16
Q

Amoxapine

A

Blocks reuptake of NE; blocks dopamine receptors (antipsychotic)

17
Q

Name antipsychotics

A

addons for antidepressants
Aripiprazole, brexpiprazole, quetiapine

18
Q

Benzodiazepines

A

Enhance the effect of GABA at the GABA receptor

19
Q

Hydroxyzine

A

Histamine H1 receptor antagonist

20
Q

Buspirone

A

5HT1a receptor agonist; also acts on dopamine receptors

21
Q

Prazosin (Minipress)

A

Prazosin (Minipress) - α1-adrenergic blocker - insomnia

Hunts BD (10 decks)

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