MOA by class

Question 1

HMG-CoA Reductase Inhibitors

Answer 1

Inhibits enzyme responsible for converting HMG-CoA to mevalonate (rate limiting step in production of cholesterol)

Question 2

Niacin (AKA Vitamin B3)

Answer 2

Inhibits the hepatic production of VLDL and consequently its metabolite LDL-C

Question 3

Ezetimibe

Answer 3

Selective inhibitor of dietary and biliary cholesterol absorption

Question 4

Bile Acid Sequestrants

Answer 4

Binds bile acids in the intestine, decreasing biliary cholesterol absoprtion

Question 5

Fibrates

Answer 5

Peroxisome proliferator-actived receptor alpha activation, reduced hepatic secretion of VLDL, induciton of lipoprotein lipase-mediated lipolysis and clearance of TG

Question 6

Omega 3 Fatty Acids

Answer 6

Inhibits hepatic secretion of TG and promotes metabolism of TG