MOA

Question 1

different Rx efficacy in people

Answer 1

SNPs

Question 2

allows for different phenotypes from same gene

Answer 2

alternative splicing

Question 3

GABA_ is a GPCR

Answer 3

GABA-B

Question 4

mu opioid receptors allow for ___ outflow and prevent ___ entry

Answer 4

K
Ca

Question 5

protease activated receptors (PAR) are examples of ___

Answer 5

GPCR

Question 6

GPCR desensitization MOA

Answer 6

phosphorylation
internalization

Question 7

kinase-linked receptors

Answer 7

single transmembrane domain
dimerize and autophosphorylate
alter gene expression

Question 8

insulin receptor turns on ___ and ___ pathways

Answer 8

PI3K
MAPK

Question 9

serine/threonine kinase example

Answer 9

TGF

Question 10

most cytoplasmic nuclear receptors form ___ when bound

Answer 10

homodimers

Question 11

RXR and TH form ___

Answer 11

heterodimers (cytoplasmic)

Question 12

most ___ ___ receptors are bound to heat shock proteins when not bound to ligand

Answer 12

cytoplasmic nuclear

Question 13

phase 0 in CAP

Answer 13

Na influx

Question 14

phase 1 in CAP

Answer 14

Ca influx
K efflux

Question 15

phase 2 in CAP

Answer 15

Ca influx

Question 16

phase 3 in CAP

Answer 16

K efflux

Question 17

phase 4 in CAP

Answer 17

resting