Kinetics Flashcards
1
Q
unrelated to therapeutic effect
predictable
dose-related
A
side effect
2
Q
exaggeration of therapeutic effect
predictable
dose-related
A
toxic reaction
3
Q
body on the Rx
A
kinetics
4
Q
Rx on the body
A
dynamics
5
Q
pharmaco___ can be used to calculate dosing
A
kinetics
6
Q
___ can be used to determine maintenance dosing
A
clearance
7
Q
___ determines loading dose
A
Vd
8
Q
___ determines steady state and dosing interval
A
t 1/2
9
Q
___, ___, and ___ can be derived from the time/concentration curve
A
Cl
Vd
t 1/2
10
Q
t 1/2 decreases over time
independent of [Rx]
rate-limited
A
zero order
11
Q
1/2 stays the same
[Rx] decreases by 50% per t 1/2
[Rx] dependent
A
first order
12
Q
absorbed = eliminated = ___
A
Css
13
Q
D = (VD X CSS) / F
A
initial loading dose
14
Q
D = (VD)(CSS – CMEASURED) / F
A
repeat loading dose
15
Q
___ = 0.693/ke
A
t 1/2
