MOA

Question 1

SABA/LABA

Answer 1

B2 receptor agonist which increases cAMP, activating protein kinase A which increased conductance of K+ through Ca2+ sensitive K+ channels into airway smooth muscle cells, leading to hyper polarisation and relaxation. Can also increase ciliary beat freq

Question 2

SAMA/LAMA

Answer 2

Blocks PSNS Ach stimulation via M3 muscarinic receptor, decreasing bronchial tone and preventing bronchoconstriction

Question 3

Methylxanthines

Answer 3

Phosphodiesterase inhibitor, inhibits the degradation of cAMP, increasing bronchial smooth muscle relaxation

Question 4

Leukotriene receptor antagonist

Answer 4

Inhibit the leukotriene pathway, preventing activation of inflammatory cells, bronchoconstriction

Question 5

Corticosteroids

Answer 5

Binds to nuclear steroid complex which translocates to the nucleus and alters transcription of anti inflammatory genes (e.g. upregulates lipocortin-1 which upregulates anti inflammatory and down regulates pro inflammatory molecules)

Question 6

Cromolyns

Answer 6

Stabilise mast cell membrane and reduce release of mast cell inflammatory mediators, reduce chemotactic induced influx of inflammatory cells